Pazufloxacin mesilate

Product Name: Pazufloxacin mesilate
CAS No.: 163680-77-1
Chemical Name: Pazufloxacin mesilate
Synonyms: PASIL;T 3762;PAZUCROSS;PAZUFLOXACIN MESYLAS;Pazufloxacin mesilat;Mesylate pazufloxacin;PAZUFLOXACIN MESYLATE;PAZUFLOXACIN MESILATE;Pasofloxacin mesylate;PazufloxacinMesylate>
CBNumber: CB6188647
Molecular Formula: C17H19FN2O7S
Formula Weight: 414.4053632
MOL File: 163680-77-1.mol

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Pazufloxacin mesilate Property

Melting point:: >255°C (dec.)
alpha: D20 -64.2° (c = 1 in 1.0N NaOH)
storage temp.: -20°C Freezer
solubility: Aqueous Base (Slightly), DMSO (Slightly)
form: Solid
color: Off-White to Pale Yellow
CAS DataBase Reference: 163680-77-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C,F
Risk Statements: 36/37/38-34-11
Safety Statements: 26-45-36/37/39-16
RTECS: UU8815400
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P1962
Product name: Pazufloxacin Mesylate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: P1962
Product name: Pazufloxacin Mesylate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $103
Updated: 2023/06/20

Cayman Chemical

Product number: 29249
Product name: Pazufloxacin (mesylate)
Packaging: 1g
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 29249
Product name: Pazufloxacin (mesylate)
Packaging: 25g
Price: $485
Updated: 2024/03/01

Cayman Chemical

Product number: 29249
Product name: Pazufloxacin (mesylate)
Packaging: 5g
Price: $116
Updated: 2024/03/01

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Pazufloxacin mesilate Chemical Properties,Usage,Production

Description

This fluoroquinolone was co-developed by Toyama and Mitsubishi Pharm and was launched for the intravenous therapy of respiratory, urinary, surgical, gynecological and systemic infections.

Description

Pazufloxacin is a broad-spectrum synthetic fluoroquinolone antibiotic. It is active against Gram-negative and Gram-positive bacteria, including clinical isolates of E. coli, K. pneumoniae, methicillin-susceptible and -resistant S. aureus, and methicillin-susceptible and -resistant S. epidermidis (MIC₉₀s = 0.05, 0.1, 0.39, 12.5, 0.39, and 6.25 μg/ml, respectively). It inhibits E. coli, P. aeruginosa, and S. aureus DNA gyrase (IC₅₀s = 0.88, 1.9, and 10.2 μg/ml, respectively) and S. aureus topoisomerase IV (IC₅₀ = 24.2 μg/ml) in cell-free assays. In vivo, pazufloxacin is active against systemic E. coli, K. pneumoniae, and methicillin-resistant S. aureus infections in mice (ED₅₀s = 0.15, 5.5, and 4.5 mg/kg, respectively).

Chemical Properties

Crystalline Solid

Uses

A fluorinated quinolone antibiotic. Antibacterial.

Synthesis

Pazufloxacin Mesilate is elegantly synthesized from commercially available 2,3,4,5-tetrafluorobenzoic acid (168) by an 11-step process with an overall yield 48% [68]. Starting material 168 was first treated with ethyl bromide and then with t-butyl cyanoacetate in the presence of potassium carbonate in DMSO in one flask to give acylated cyanoacetate 169. Intermediate 169 thus obtained without purification was refluxed in toluene with p-TSA to yield 4- cyanomethylbenzoate 170 in 90% yield from 168. Cyclopropanation at the benzylic position of 170 was performed by |á,|á-dialkylation with two equiv. of 1,2- dibromoethane under phase-transfer conditions to give cyanocyclopropyl compound 171. Cyano compound 171 was subjected to hydration with alkaline H2O2 to afford carboxamide 172 in 81% yield from 170. Subsequently, carboxamide 172 was treated with NaOCl for Hofmann rearrangement to give primary amine 173, which was protected as its N-acetyl derivative 174 for the next reaction. Treatment of 174 with imidazole in the presence of thionyl chloride and TEA generated an imidazolide intermediate, which was converted to |?-keto ester 175 by reacting with potassium ethyl malonate and MgCl2. Enamine 176 was obtained without purification by successive treatment of 175 with DMF-dimethylacetal and (S)-(+)-2-aminopropanol. Crude 176 was heated in DMSO in the presence of potassium carbonate to efficiently give tricycle product 177 in 80% yield from 174. Finally, the ethyl ester and acetamide in 177 were hydrolyzed under basic and acidic conditions, respectively, to give the free amine. Pazufloxacin mesilate (20) was obtained in 94% yield by treatment of its corresponding free amine with methanesulfonic acid in ethanol.

Pazufloxacin mesilate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pazufloxacin mesilate Suppliers

Canada 2 CHINA 272 Europe 2 Germany 2 India 15 Japan 1 Poland 1 Switzerland 2 United Kingdom 9 United States 31 Global 337

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
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Minglong (Xianning) Pharmaceutical Co., LTD

Tel: 155-7155-6913 15571556913
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Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Meryer (Shanghai) Chemical Technology Co., Ltd.

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ProdList: 40228
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
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Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
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Nanjing Kaitian Chemical Co., Ltd.

Tel: +86 (25) 5860-8846
Fax: +86 (25) 5860-8846
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Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
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View Lastest Price from Pazufloxacin mesilate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pazufloxacin mesilate 163680-77-1
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500KG
Release date: 2021-09-18

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Pazufloxacin mesilate 163680-77-1
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-11-09

Hebei Mojin Biotechnology Co., Ltd

Product: Pazufloxacin mesilate 163680-77-1
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2021-06-11

163680-77-1, Pazufloxacin mesilateRelated Search:

5-Amino-2-methylpyridine 4-Aminopyridine Pefloxacin mesylate 3-Aminopyridine METSULFURON METHYL Bensulfuron methyl Kresoxim-methyl Methyl salicylate Thiophanate-methyl Methanesulfonic acid Phentolamine mesilate 4-Dimethylaminopyridine Methyl Fluorine PAZUFLOXACIN (PREPARATION FOR PAZUFLOXACIN MESILATE) Methyl bromide PAZUFLOXACIN MESYLATE methanesulfonate

(3S)-10-(1-AMinocyclopropyl)-9-fluror-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Methanesulfonate

Mesylate pazufloxacin

T 3762

PASIL

PAZUCROSS

PAZUFLOXACIN MESILATE

PAZUFLOXACIN MESYLATE

PAZUFLOXACIN METHANESULFONATE

pazufloxaxin methanesulfonate

(s)-yclopropyl)-9-fluoro-3-methyl-7-oxomonomethanesulfonate

2,3-de)-1,4-benzoxazine-6-carboxylicacid,2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-7h-pyrido((s)-7h-pyrido(monomethanesulfonate

Pazufloxacin Monomethanesulfonate

Pazufloxacin mesilate VETRANAL

PAZUFLOXAXIN METHANESULFONATE 99%

(3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid,

(3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid, T-3761,

PAZUFLOXACIN MESYLAS

(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid methanesulfonate

Pazufloxacin mesilat

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate (9CI)

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-, monomethanesulfonate

Pazufloxacin mesylate, Pazufloxacin methanesulfonate

PazufloxacinMesylate&gt

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)

Pazufloxacin mesilate USP/EP/BP

Pazufloxacin mesylateQ: What is Pazufloxacin mesylate Q: What is the CAS Number of Pazufloxacin mesylate Q: What is the storage condition of Pazufloxacin mesylate Q: What are the applications of Pazufloxacin mesylate

(S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonic acid salt

Pazufloxacin Mesylate, ≥ 98.0%

Pasofloxacin mesylate

Pazucross|||Pazufloxacin mesilate|||T-3762|||Pazufloxacin methanesulfonate

163680-77-1

103680-77-1

C16H15FN2O4xCH3SO3H

C16H15FN2O4CH4SO3

C16H15FN2O4CH3SO3H

C17H19FN2O7S

C16H15FN2O4CH4O3S

C17H19FN2SO7

PAZUCROSS

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