Danoprevir
- Product Name
- Danoprevir
- CAS No.
- 850876-88-9
- Chemical Name
- Danoprevir
- Synonyms
- Danoprevir;RG7227;Intepirdine;CS-64;R7227;RG72277;ITMN-191;RO5190591;Danpprevir;Danoprevir, >=98%
- CBNumber
- CB02504568
- Molecular Formula
- C35H46FN5O9S
- Formula Weight
- 731.83
- MOL File
- 850876-88-9.mol
Danoprevir Property
- Melting point:
- >165°C (dec.)
- Density
- 1.41
- storage temp.
- -20°C Freezer
- solubility
- Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.43±0.60(Predicted)
- color
- White to Pale Beige
- InChI
- InChI=1S/C35H46FN5O9S/c1-34(2,3)50-32(45)37-27-13-8-6-4-5-7-11-22-17-35(22,31(44)39-51(47,48)24-14-15-24)38-29(42)28-16-23(19-41(28)30(27)43)49-33(46)40-18-21-10-9-12-26(36)25(21)20-40/h7,9-12,22-24,27-28H,4-6,8,13-20H2,1-3H3,(H,37,45)(H,38,42)(H,39,44)/b11-7+/t22-,23-,27+,28+,35-/m1/s1
- InChIKey
- ZVTDLPBHTSMEJZ-AIYSODCISA-N
- SMILES
- C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O |t:33|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 24185
- Product name
- Danoprevir
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 24185
- Product name
- Danoprevir
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $211
- Updated
- 2024/03/01
- Product number
- 24185
- Product name
- Danoprevir
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $357
- Updated
- 2024/03/01
- Product number
- D172820
- Product name
- Danoprevir
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- D172820
- Product name
- Danoprevir
- Packaging
- 2.5mg
- Price
- $120
- Updated
- 2021/12/16
Danoprevir Chemical Properties,Usage,Production
Description
Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC50 = 1 nM), a serine protease essential for HCV replication. It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM).
Uses
Danoprevir is a selective and potent inhibitor of Hepatitis C virus.
target
HCV NS3/4A protease
Danoprevir Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Danoprevir manufacturers
- Product
- Danoprevir 850876-88-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Danoprevir 850876-88-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09