ChemicalBook > CAS DataBase List > Methyl-5-(bromomethyl)pyrazine-2-carboxylate

Methyl-5-(bromomethyl)pyrazine-2-carboxylate

Product Name
Methyl-5-(bromomethyl)pyrazine-2-carboxylate
CAS No.
193966-70-0
Chemical Name
Methyl-5-(bromomethyl)pyrazine-2-carboxylate
Synonyms
pyrazine-2-carboxylate;Methyl 5-(bromomethyl);Methyl-5-(bromomethyl)pyrazine-2-carboxylate
CBNumber
CB02504856
Molecular Formula
C7H7BrN2O2
Formula Weight
231.04668
MOL File
193966-70-0.mol
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Methyl-5-(bromomethyl)pyrazine-2-carboxylate Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
White to off-white Solid
InChI
InChI=1S/C7H7BrN2O2/c1-12-7(11)6-4-9-5(2-8)3-10-6/h3-4H,2H2,1H3
InChIKey
OIGRHUBIDWZLHR-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)=NC=C(CBr)N=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M296965
Product name
Methyl5-(Bromomethyl)pyrazine-2-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
W4143
Product name
Methyl-5-(bromomethyl)pyrazine-2-carboxylate
Packaging
100mg
Price
$79
Updated
2021/12/16
AK Scientific
Product number
W4143
Product name
Methyl-5-(bromomethyl)pyrazine-2-carboxylate
Packaging
250mg
Price
$118
Updated
2021/12/16
AK Scientific
Product number
J96947
Product name
Methyl-5-(bromomethyl)pyrazine-2-carboxylate
Packaging
1g
Price
$244
Updated
2021/12/16
Matrix Scientific
Product number
074626
Product name
Methyl 5-(bromomethyl)pyrazine-2-carboxylate
Purity
95+%
Packaging
1g
Price
$439
Updated
2021/12/16
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Methyl-5-(bromomethyl)pyrazine-2-carboxylate Chemical Properties,Usage,Production

Synthesis

41110-33-2

193966-70-0

Methyl 5-methylpyrazine-2-carboxylate (0.5 g, 3.28 mmol) was dissolved in acetic acid (5 mL) at room temperature and bromine (0.9 mL, 3.6 mmol) was added slowly. The reaction mixture was heated to 80 °C and kept for 45 min. Upon completion of the reaction, it was concentrated under reduced pressure to remove the acetic acid. The residue was adjusted to basicity with saturated sodium bicarbonate solution and subsequently extracted with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford methyl 5-bromomethylpyrazine-2-carboxylate (0.3 g, 40% yield) as a brown liquid using hexane solution of 20% ethyl acetate as eluent. Mass spectrometry analysis (ESI): calculated value [M+H]+ 230.97, measured value [M+H]+ 231.0.

References

[1] Patent: WO2015/48503, 2015, A2. Location in patent: Paragraph 0138
[2] Patent: WO2017/18803, 2017, A1. Location in patent: Paragraph 2039; 2040; 2041
[3] Patent: EP1389460, 2004, A1. Location in patent: Page/Page column 36
[4] ACS Combinatorial Science, 2012, vol. 14, # 3, p. 164 - 169
[5] Medicinal Chemistry Research, 2015, vol. 24, # 7, p. 2986 - 2992

Methyl-5-(bromomethyl)pyrazine-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl-5-(bromomethyl)pyrazine-2-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Methyl 5-(bromomethyl)pyrazine-2-carboxylate 193966-70-0
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-18
Career Henan Chemical Co
Product
Methyl-5-(bromomethyl)pyrazine-2-carboxylate 193966-70-0
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-14

193966-70-0, Methyl-5-(bromomethyl)pyrazine-2-carboxylateRelated Search:

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  • Methyl-5-(bromomethyl)pyrazine-2-carboxylate
  • Methyl 5-(bromomethyl)
  • pyrazine-2-carboxylate
  • 193966-70-0