METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
- Product Name
- METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
- CAS No.
- 55876-84-1
- Chemical Name
- METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
- Synonyms
- Methyl 5-(bromomethyl)picolinate;THYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE;5-Bromomethyl-2-(1-methoxy-vinyl)-pyridine;METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE;5-(Bromomethyl)pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 5-(bromomethyl)-, methyl ester
- CBNumber
- CB2337933
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 55876-84-1.mol
METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE Property
- Boiling point:
- 334℃
- Density
- 1.533
- Flash point:
- 156℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.78±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- HCH0014247
- Product name
- METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 2G
- Price
- $420
- Updated
- 2021/12/16
- Product number
- HCH0014247
- Product name
- METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $430.5
- Updated
- 2021/12/16
- Product number
- HCH0014247
- Product name
- METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $472.5
- Updated
- 2021/12/16
- Product number
- 5915CY
- Product name
- Methyl5-(bromomethyl)picolinate
- Packaging
- 1g
- Price
- $787
- Updated
- 2021/12/16
- Product number
- 5915CY
- Product name
- Methyl5-(bromomethyl)picolinate
- Packaging
- 2.5g
- Price
- $1558
- Updated
- 2021/12/16
METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
29681-38-7
55876-84-1
General procedure for the synthesis of 5-bromomethylpyridine-2-carboxylic acid methyl ester from 5-methylpyridine-2-carboxylic acid: in a 500 mL round bottom flask, N-bromosuccinimide (NBS, 14.13 g, 79.38 mmol, 1.20 eq.) and azobisisobutyronitrile (AIBN, 217 mg, 1.32 mmol, 0.02 eq.) were added to a 5- methyl pyridine-2-carboxylate (10 g, 66.15 mmol, 1.00 equiv) in a solution of carbon tetrachloride (CCl4, 200 mL). The reaction mixture was stirred at 80 °C for 16 hours. After completion of the reaction, the mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (5% to 25% gradient) as eluent to afford methyl 5-bromomethylpyridine-2-carboxylate (9.6 g, 57% yield) as a yellow solid. Mass spectrum (MS): m/z = 229.9 [M + H]+.
References
[1] Patent: US2016/96834, 2016, A1. Location in patent: Paragraph 0328
[2] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 90
[3] Patent: WO2012/80221, 2012, A1. Location in patent: Page/Page column 84
[4] Patent: US2013/274260, 2013, A1. Location in patent: Paragraph 0622-0623
[5] Patent: WO2013/3505, 2013, A1. Location in patent: Page/Page column 58
METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE manufacturers
- Product
- methyl 5-(bromomethyl)pyridine-2-carboxylate 55876-84-1
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2019-12-27
- Product
- METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE 55876-84-1
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10