METHYL 3-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
- Product Name
- METHYL 3-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
- CAS No.
- 116986-09-5
- Chemical Name
- METHYL 3-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
- Synonyms
- Methyl 3-(bromomethyl);methyl 3-(bromomethyl)picolinate;METHYL 3-BROMOMETHYLPYRIDINE-2-CARBOXYLATE;3-Bromomethyl-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 3-(bromomethyl)-, methyl ester
- CBNumber
- CB3176816
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 116986-09-5.mol
METHYL 3-BROMOMETHYLPYRIDINE-2-CARBOXYLATE Property
- Boiling point:
- 338.6±32.0 °C(Predicted)
- Density
- 1.533±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.57±0.10(Predicted)
- Appearance
- Off-white to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M296625
- Product name
- Methyl3-(Bromomethyl)picolinate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4347AJ
- Product name
- Methyl3-bromomethylpyridine-2-carboxylate
- Packaging
- 10g
- Price
- $1738
- Updated
- 2021/12/16
- Product number
- HCH0105877
- Product name
- METHYL-3-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.87
- Updated
- 2021/12/16
- Product number
- 4347AJ
- Product name
- Methyl3-bromomethylpyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $151
- Updated
- 2021/12/16
- Product number
- CM247959
- Product name
- Methyl3-(bromomethyl)picolinate
- Purity
- 97%
- Packaging
- 1g
- Price
- $204
- Updated
- 2021/12/16
METHYL 3-BROMOMETHYLPYRIDINE-2-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
59718-84-2
116986-09-5
General procedure for the synthesis of methyl 3-(bromomethyl)pyridine-2-carboxylate from methyl 3-methylpyridine-2-carboxylate: methyl 3-methylpyridine-2-carboxylate (4.1 g, 27.1 mmol), N-bromosuccinimide (NBS, 5.8 g, 32.5 mmol) and azobisisobutyronitrile (AIBN, 100 mg, 0.61 mmol) were dissolved in carbon tetrachloride (55 mL). The reaction mixture was stirred at 90 °C for 16 h under nitrogen protection. After completion of the reaction, the mixture was filtered and the filtrate was concentrated. The concentrate was purified by column chromatography to afford the target product methyl 3-(bromomethyl)pyridine-2-carboxylate (5.0 g, 80.6% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.67 (dd, J = 1.6, 4.6 Hz, 1H), 7.91 (dd, J = 1.5, 7.9 Hz, 1H), 7.48 (dd, J = 4.6, 7.9 Hz, 1H), 4.95 (s, 2H), 4.07-4.03 (m, 3H). lCMS ( m/z): 229.9 ([M + H]+).
References
[1] Patent: WO2015/200677, 2015, A2. Location in patent: Paragraph 00472; 00473
[2] Journal fuer Praktische Chemie (Leipzig), 1987, vol. 329, # 4, p. 557 - 562
[3] Organic Letters, 2017, vol. 19, # 14, p. 3895 - 3898
METHYL 3-BROMOMETHYLPYRIDINE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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