ChemicalBook > CAS DataBase List > EX527

EX527

Product Name: EX527
CAS No.: 848193-68-0
Chemical Name: EX527
Synonyms: EX527;CS-573;EX-527(S);(±)-EX-527;(S)-Selisistat;EX-527 (S-enantioMer);Selisistat S-enantiomer;Selisistat S-enantiomer, 10 mM in DMSO;Selisistat S-enantiomer(EX-527 S-enantiomer);(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
CBNumber: CB02507286
Molecular Formula: C13H13ClN2O
Formula Weight: 248.71
MOL File: 848193-68-0.mol

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EX527 Property

Boiling point:: 531.7±38.0 °C(Predicted)
Density: 1.388
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 16.12±0.40(Predicted)
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 2780
Product name: EX 527
Purity: ≥98%(HPLC)
Packaging: 10
Price: $223
Updated: 2021/12/16

Usbiological

Product number: 366881
Product name: EX 527
Packaging: 10mg
Price: $296
Updated: 2021/12/16

Usbiological

Product number: 255275
Product name: EX 527
Packaging: 1mg
Price: $333
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb545819
Product name: EX 527
Purity: >98%
Packaging: 5mg
Price: $190.4
Updated: 2021/12/16

ChemScene

Product number: CS-3574
Product name: SelisistatS-enantiomer
Purity: 98.50%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

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EX527 Chemical Properties,Usage,Production

Uses

(S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.

Definition

ChEBI: (S)-selisistat is a 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide that has S configuration It is the active enantiomer. It has a role as a Sir1 inhibitor. It is an enantiomer of a (R)-selisistat.

in vivo

(S)-Selisistat abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group^[3].

IC 50

SIRT1: 98 nM (IC₅₀)

References

[1] Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38. DOI:10.1128/MCB.26.1.28-38.2006
[2] Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849. DOI:10.1371/journal.pone.0120849
[3] Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17. DOI:10.1002/oby.21086
[4] Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DOI:10.1021/jm050522v

EX527 Preparation Products And Raw materials

Raw materials

Preparation Products

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848193-68-0, EX527Related Search:

Aluminum oxide 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE EX-527 (R-enantioMer)

EX527

(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

EX-527(S)

EX-527(S),(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxaMide

EX-527 (S-enantioMer)

Selisistat S-enantiomer(EX-527 S-enantiomer)

Selisistat S-enantiomer

CS-573

(S)-Selisistat

EX-527(S); (S)-SELISISTAT; EX 527(S); EX527(S); EX-527S; EX527S;

1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, (1S)-

Selisistat S-enantiomer, 10 mM in DMSO

(±)-EX-527

848193-68-0

49843-93-3