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EX527

Product Name
EX527
CAS No.
848193-68-0
Chemical Name
EX527
Synonyms
EX527;CS-573;EX-527(S);(±)-EX-527;(S)-Selisistat;EX-527 (S-enantioMer);Selisistat S-enantiomer;Selisistat S-enantiomer, 10 mM in DMSO;Selisistat S-enantiomer(EX-527 S-enantiomer);(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
CBNumber
CB02507286
Molecular Formula
C13H13ClN2O
Formula Weight
248.71
MOL File
848193-68-0.mol
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EX527 Property

Boiling point:
531.7±38.0 °C(Predicted)
Density 
1.388
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
16.12±0.40(Predicted)
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
2780
Product name
EX 527
Purity
≥98%(HPLC)
Packaging
10
Price
$223
Updated
2021/12/16
Usbiological
Product number
366881
Product name
EX 527
Packaging
10mg
Price
$296
Updated
2021/12/16
Usbiological
Product number
255275
Product name
EX 527
Packaging
1mg
Price
$333
Updated
2021/12/16
ChemScene
Product number
CS-3574
Product name
SelisistatS-enantiomer
Purity
98.50%
Packaging
5mg
Price
$420
Updated
2021/12/16
Biorbyt Ltd
Product number
orb545819
Product name
EX 527
Purity
>98%
Packaging
25mg
Price
$521.9
Updated
2021/12/16
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EX527 Chemical Properties,Usage,Production

Uses

(S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.

Definition

ChEBI: (S)-selisistat is a 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide that has S configuration It is the active enantiomer. It has a role as a Sir1 inhibitor. It is an enantiomer of a (R)-selisistat.

in vivo

(S)-Selisistat abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group[3].

IC 50

SIRT1: 98 nM (IC50)

References

[1] Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38. DOI:10.1128/MCB.26.1.28-38.2006
[2] Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849. DOI:10.1371/journal.pone.0120849
[3] Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17. DOI:10.1002/oby.21086
[4] Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DOI:10.1021/jm050522v

EX527 Preparation Products And Raw materials

Raw materials

Preparation Products

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EX527 Suppliers

China 91 India 1 United States 9 Global 101
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

848193-68-0, EX527Related Search:

Aluminum oxide 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE EX-527 (R-enantioMer)

  • EX527
  • (1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
  • EX-527(S)
  • EX-527(S),(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxaMide
  • EX-527 (S-enantioMer)
  • Selisistat S-enantiomer(EX-527 S-enantiomer)
  • Selisistat S-enantiomer
  • CS-573
  • (S)-Selisistat
  • EX-527(S); (S)-SELISISTAT; EX 527(S); EX527(S); EX-527S; EX527S;
  • 1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, (1S)-
  • Selisistat S-enantiomer, 10 mM in DMSO
  • (±)-EX-527
  • 848193-68-0
  • 49843-93-3