4-AMino-5-Methylpyridin-2-ol
- Product Name
- 4-AMino-5-Methylpyridin-2-ol
- CAS No.
- 95306-64-2
- Chemical Name
- 4-AMino-5-Methylpyridin-2-ol
- Synonyms
- 4-AMino-5-Methylpyridin-2(1H)-one;4-amino-5-methyl-1H-pyridin-2-one;4-Amino-2-hydroxy-5-methylpyridine;Degarelix Impurity 4;Finerenone Impurity A;Finerenone Impurity 28;Felodipine Impurity 14;Finerenone intermediate;4-amino-5-methylpyridone;4-AMino-5-Methylpyridin-2-ol
- CBNumber
- CB02507291
- Molecular Formula
- C6H8N2O
- Formula Weight
- 124.14
- MOL File
- 95306-64-2.mol
4-AMino-5-Methylpyridin-2-ol Property
- Boiling point:
- 291.0±33.0℃ (760 Torr)
- Density
- 1.137±0.06 g/cm3 (20 ºC 760 Torr)
- vapor pressure
- 0-0Pa at 20-50℃
- Flash point:
- 129.8±25.4℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 11.90±0.10(Predicted)
- LogP
- -0.51 at 20℃ and pH6.3
- CAS DataBase Reference
- 95306-64-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A617510
- Product name
- 4-Amino-5-methylpyridin-2(1H)-one
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FA16237
- Product name
- 4-Amino-5-methyl-2(1H)-pyridinone
- Packaging
- 2g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-W022074
- Product name
- 4-Amino-5-methylpyridin-2-ol
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $260
- Updated
- 2021/12/16
- Product number
- CS-W022074
- Product name
- 4-Amino-5-methylpyridin-2-ol
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
- Product number
- CS-W022074
- Product name
- 4-Amino-5-methylpyridin-2-ol
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
4-AMino-5-Methylpyridin-2-ol Chemical Properties,Usage,Production
Description
4-AMino-5-Methylpyridin-2-ol belongs to the pyridine derivatives and is significantly alkaline. Its alcoholic hydroxyl group can undergo corresponding nucleophilic substitution reactions under alkaline conditions. It can be used as a material in organic synthesis and medicinal chemistry. The intermediate is used for the modification and production of drug molecules. For example, the compound can prepare selective mineralocorticoid receptor (MR) antagonist finerenone, which is used to lower the risk of severe kidney and heart problems.
Uses
4-Amino-5-methylpyridin-2(1H)-one has been used as a reactant for the synthesis of BAY 94-8862, a nonsteroidal antagonist of the mineralocorticoid receptor to be used for the treatment of cardiorenal diseases.
Synthesis
2-Chloro-4-amino-5-methylpyridine, dissolved in ethylene glycol, could be a starting material to synthesize 4-AMino-5-Methylpyridin-2-ol. The crude product could be precipitated by adding hydrochloric acid/methanol solution.
4-AMino-5-Methylpyridin-2-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMino-5-Methylpyridin-2-ol manufacturers
- Product
- 4-Amino-2-hydroxy-5-methylpyridine 95306-64-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2024-01-04
- Product
- 4-AMino-5-Methylpyridin-2(1H)-one 95306-64-2
- Price
- US $10.00-3.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-29
- Product
- 4-Amino-5-methyl-2(1H)-pyridinone 95306-64-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2023-03-16