4-Amino-2-hydroxy-5-methylpyridine
- Product Name
- 4-Amino-2-hydroxy-5-methylpyridine
- CAS No.
- 95306-64-2
- Chemical Name
- 4-Amino-2-hydroxy-5-methylpyridine
- Synonyms
- 4-AMino-5-Methylpyridin-2(1H)-one;4-amino-5-methyl-1H-pyridin-2-one;4-Amino-2-hydroxy-5-methylpyridine;Degarelix Impurity 4;Finerenone Impurity A;Finerenone Impurity 28;Felodipine Impurity 14;Finerenone intermediate;4-amino-5-methylpyridone;4-AMino-5-Methylpyridin-2-ol
- CBNumber
- CB02507291
- Molecular Formula
- C6H8N2O
- Formula Weight
- 124.14
- MOL File
- 95306-64-2.mol
4-Amino-2-hydroxy-5-methylpyridine Property
- Boiling point:
- 291.0±33.0℃ (760 Torr)
- Density
- 1.137±0.06 g/cm3 (20 ºC 760 Torr)
- vapor pressure
- 0-0Pa at 20-50℃
- Flash point:
- 129.8±25.4℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 11.90±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9)
- InChIKey
- SSQZBQXJYGNUSC-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(C)C(N)=C1
- LogP
- -0.51 at 20℃ and pH6.3
- CAS DataBase Reference
- 95306-64-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A617510
- Product name
- 4-Amino-5-methylpyridin-2(1H)-one
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FA16237
- Product name
- 4-Amino-5-methyl-2(1H)-pyridinone
- Packaging
- 2g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-W022074
- Product name
- 4-Amino-5-methylpyridin-2-ol
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $260
- Updated
- 2021/12/16
- Product number
- CS-W022074
- Product name
- 4-Amino-5-methylpyridin-2-ol
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
- Product number
- CS-W022074
- Product name
- 4-Amino-5-methylpyridin-2-ol
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
4-Amino-2-hydroxy-5-methylpyridine Chemical Properties,Usage,Production
Description
4-Amino-2-hydroxy-5-methylpyridine belongs to the pyridine derivatives and is significantly alkaline. Its alcoholic hydroxyl group can undergo corresponding nucleophilic substitution reactions under alkaline conditions. It can be used as a material in organic synthesis and medicinal chemistry. The intermediate is used for the modification and production of drug molecules.
Chemical Properties
4-Amino-5-methyl-2-hydroxypyridine is insoluble in water and soluble in strong polar organic solvents. It has an amino group in its structure and therefore exhibits significant basicity. The carbonyl group in the structure can be considered to exist in an enolic form, and its alcoholic hydroxyl group can undergo the corresponding nucleophilic substitution reaction under basic conditions.
Uses
4-Amino-2-hydroxy-5-methylpyridine has been used as a reactant for the synthesis of finerenone, a selective mineralocorticoid receptor (MR) antagonist to be used to lower the risk of severe kidney and heart problems.
Synthesis
4-Amino-2-hydroxy-5-methylpyridine, dissolved in ethylene glycol, could be a starting material to synthesize 4-AMino-5-Methylpyridin-2-ol. The crude product could be precipitated by adding hydrochloric acid/methanol solution.
4-Amino-2-hydroxy-5-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-2-hydroxy-5-methylpyridine manufacturers
- Product
- 4-Amino-5-methylpyridin-2-ol 95306-64-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-26
- Product
- 4-AMino-5-Methylpyridin-2-ol 95306-64-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 800kg
- Release date
- 2025-03-11
- Product
- 4-Amino-2-hydroxy-5-methylpyridine 95306-64-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ≥98% by HPLC
- Supply Ability
- 100kg/month
- Release date
- 2023-01-05