ChemicalBook > CAS DataBase List > 4-AMino-5-Methylpyridin-2-ol

4-AMino-5-Methylpyridin-2-ol

Product Name
4-AMino-5-Methylpyridin-2-ol
CAS No.
95306-64-2
Chemical Name
4-AMino-5-Methylpyridin-2-ol
Synonyms
4-AMino-5-Methylpyridin-2(1H)-one;4-amino-5-methyl-1H-pyridin-2-one;4-Amino-2-hydroxy-5-methylpyridine;Degarelix Impurity 4;Finerenone Impurity A;Finerenone Impurity 28;Felodipine Impurity 14;Finerenone intermediate;4-amino-5-methylpyridone;4-AMino-5-Methylpyridin-2-ol
CBNumber
CB02507291
Molecular Formula
C6H8N2O
Formula Weight
124.14
MOL File
95306-64-2.mol
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4-AMino-5-Methylpyridin-2-ol Property

Boiling point:
291.0±33.0℃ (760 Torr)
Density 
1.137±0.06 g/cm3 (20 ºC 760 Torr)
vapor pressure 
0-0Pa at 20-50℃
Flash point:
129.8±25.4℃
storage temp. 
2-8°C(protect from light)
pka
11.90±0.10(Predicted)
InChI
InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9)
InChIKey
SSQZBQXJYGNUSC-UHFFFAOYSA-N
SMILES
C1(=O)NC=C(C)C(N)=C1
LogP
-0.51 at 20℃ and pH6.3
CAS DataBase Reference
95306-64-2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A617510
Product name
4-Amino-5-methylpyridin-2(1H)-one
Packaging
1g
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA16237
Product name
4-Amino-5-methyl-2(1H)-pyridinone
Packaging
2g
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-W022074
Product name
4-Amino-5-methylpyridin-2-ol
Purity
≥98.0%
Packaging
5g
Price
$260
Updated
2021/12/16
ChemScene
Product number
CS-W022074
Product name
4-Amino-5-methylpyridin-2-ol
Purity
≥98.0%
Packaging
1g
Price
$63
Updated
2021/12/16
AK Scientific
Product number
CS-W022074
Product name
4-Amino-5-methylpyridin-2-ol
Packaging
1g
Price
$80
Updated
2021/12/16
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4-AMino-5-Methylpyridin-2-ol Chemical Properties,Usage,Production

Description

4-AMino-5-Methylpyridin-2-ol belongs to the pyridine derivatives and is significantly alkaline. Its alcoholic hydroxyl group can undergo corresponding nucleophilic substitution reactions under alkaline conditions. It can be used as a material in organic synthesis and medicinal chemistry. The intermediate is used for the modification and production of drug molecules. For example, the compound can prepare selective mineralocorticoid receptor (MR) antagonist finerenone, which is used to lower the risk of severe kidney and heart problems.

Uses

4-Amino-5-methylpyridin-2(1H)-one has been used as a reactant for the synthesis of BAY 94-8862, a nonsteroidal antagonist of the mineralocorticoid receptor to be used for the treatment of cardiorenal diseases.

Synthesis

2-Chloro-4-amino-5-methylpyridine, dissolved in ethylene glycol, could be a starting material to synthesize 4-AMino-5-Methylpyridin-2-ol. The crude product could be precipitated by adding hydrochloric acid/methanol solution.

4-AMino-5-Methylpyridin-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMino-5-Methylpyridin-2-ol Suppliers

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View Lastest Price from 4-AMino-5-Methylpyridin-2-ol manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.
Product
4-Amino-2-hydroxy-5-methylpyridine 95306-64-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% by HPLC
Supply Ability
100kg/month
Release date
2023-01-05
Nanjing Fred Technology Co., Ltd
Product
4-Amino-2-hydroxy-5-methylpyridine 95306-64-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-04
Shanghai Yongzeng Technology Co.,Ltd
Product
4-Amino-2-hydroxy-5-methylpyridine 95306-64-2
Price
US $0.00/gm
Min. Order
100gm
Purity
99%min
Supply Ability
100kgs
Release date
2024-09-04

95306-64-2, 4-AMino-5-Methylpyridin-2-olRelated Search:

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  • 4-Amino-5-methylpyridine-2-ol
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  • 95306-64-2