ChemicalBook > CAS DataBase List > 4-Amino-2-hydroxy-5-methylpyridine

4-Amino-2-hydroxy-5-methylpyridine

Product Name
4-Amino-2-hydroxy-5-methylpyridine
CAS No.
95306-64-2
Chemical Name
4-Amino-2-hydroxy-5-methylpyridine
Synonyms
4-AMino-5-Methylpyridin-2(1H)-one;4-amino-5-methyl-1H-pyridin-2-one;4-Amino-2-hydroxy-5-methylpyridine;Degarelix Impurity 4;Finerenone Impurity A;Finerenone Impurity 28;Felodipine Impurity 14;Finerenone intermediate;4-amino-5-methylpyridone;4-AMino-5-Methylpyridin-2-ol
CBNumber
CB02507291
Molecular Formula
C6H8N2O
Formula Weight
124.14
MOL File
95306-64-2.mol
More
Less

4-Amino-2-hydroxy-5-methylpyridine Property

Boiling point:
291.0±33.0℃ (760 Torr)
Density 
1.137±0.06 g/cm3 (20 ºC 760 Torr)
vapor pressure 
0-0Pa at 20-50℃
Flash point:
129.8±25.4℃
storage temp. 
2-8°C(protect from light)
pka
11.90±0.10(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9)
InChIKey
SSQZBQXJYGNUSC-UHFFFAOYSA-N
SMILES
C1(=O)NC=C(C)C(N)=C1
LogP
-0.51 at 20℃ and pH6.3
CAS DataBase Reference
95306-64-2
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
A617510
Product name
4-Amino-5-methylpyridin-2(1H)-one
Packaging
1g
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-W022074
Product name
4-Amino-5-methylpyridin-2-ol
Purity
≥98.0%
Packaging
1g
Price
$63
Updated
2021/12/16
AK Scientific
Product number
CS-W022074
Product name
4-Amino-5-methylpyridin-2-ol
Packaging
1g
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA16237
Product name
4-Amino-5-methyl-2(1H)-pyridinone
Packaging
2g
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-W022074
Product name
4-Amino-5-methylpyridin-2-ol
Purity
≥98.0%
Packaging
5g
Price
$260
Updated
2021/12/16
More
Less

4-Amino-2-hydroxy-5-methylpyridine Chemical Properties,Usage,Production

Description

4-Amino-2-hydroxy-5-methylpyridine belongs to the pyridine derivatives and is significantly alkaline. Its alcoholic hydroxyl group can undergo corresponding nucleophilic substitution reactions under alkaline conditions. It can be used as a material in organic synthesis and medicinal chemistry. The intermediate is used for the modification and production of drug molecules.

Chemical Properties

4-Amino-5-methyl-2-hydroxypyridine is insoluble in water and soluble in strong polar organic solvents. It has an amino group in its structure and therefore exhibits significant basicity. The carbonyl group in the structure can be considered to exist in an enolic form, and its alcoholic hydroxyl group can undergo the corresponding nucleophilic substitution reaction under basic conditions.

Uses

4-Amino-2-hydroxy-5-methylpyridine has been used as a reactant for the synthesis of finerenone, a selective mineralocorticoid receptor (MR) antagonist to be used to lower the risk of severe kidney and heart problems.

Synthesis

4-Amino-2-hydroxy-5-methylpyridine, dissolved in ethylene glycol, could be a starting material to synthesize 4-AMino-5-Methylpyridin-2-ol. The crude product could be precipitated by adding hydrochloric acid/methanol solution.

4-Amino-2-hydroxy-5-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Amino-2-hydroxy-5-methylpyridine Suppliers

China 286 Germany 1 India 13 United Kingdom 1 United States 7 Global 308
Jinan XuanDe Chemical Co., Ltd.
Tel
0531-88803958 18866891188
Fax
0531-82777287
Email
18853169188@163.com
Country
China
ProdList
193
Advantage
58
Hangzhou Chemtrue Bio-Tech Co.,Ltd.
Tel
0571-86828652 18857119830
Fax
0571-83522824
Email
sales@chemtrue-bio.com
Country
China
ProdList
252
Advantage
58
Hangzhou Cheminspire Technology Co., Ltd.
Tel
0571-89081561; 10006559855
Fax
0571 89081561
Email
info@cheminspire.com
Country
China
ProdList
412
Advantage
58
Shandong Sihuan Pharmaceutical Co., Ltd.
Tel
0531-88993893 13335127975
Fax
QQ:787658403
Email
fairouz@sdsihuanpharm.com
Country
China
ProdList
82
Advantage
58
Shandong Xuanshuo Pharmaceutical Technology Co. LTD
Tel
15269103900
Email
suchangzhou@shiningpharm.com
Country
China
ProdList
331
Advantage
58
Nanjing Vcare PharmaTech Co., Ltd
Tel
025-58741518 13327700685
Email
sales@vcarepharmatech.com
Country
China
ProdList
496
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
shanghai Rainbow MediTech.Co.Ltd.
Tel
021-64968085,64968086-5815,5812; 13472757003
Fax
+86 21 64968087
Email
xiaoxia.zeng@rainbowpharma.cn
Country
China
ProdList
961
Advantage
65
Jinan Chenghui Shuangda biological Co., LTD
Tel
0531-0531-58897003 15550412551
Fax
0531-58897003
Email
market@jnchsd.com
Country
China
ProdList
229
Advantage
62
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Fax
025-68710856
Email
sales@springpharma.net
Country
China
ProdList
1261
Advantage
62
Shanghai ZaiQi Bio-Tech Co., Ltd.
Tel
+86-021-54824098 15317552526
Fax
021-54824069
Email
sales@chemzq.com
Country
China
ProdList
254
Advantage
55
Suzhou Chukai PharmaTech
Tel
0512-88812066 15062531973;
Fax
86-512-63926099
Email
wenlongfcb@qq.com
Country
China
ProdList
111
Advantage
62
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shenzhen HwaGen Pharmaceutical Co.,Ltd
Tel
17722620669
Fax
0752-5319394
Email
liangcong.yi@rafflespt.com
Country
China
ProdList
279
Advantage
58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
Tel
21-33585366 13311639313
Fax
+86-21-34979012
Email
sales@shyrchem.com
Country
China
ProdList
806
Advantage
55
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-02136680027 15800370750
Email
1706640024@qq.com
Country
China
ProdList
570
Advantage
56
Ascepion Pharmaceuticals, Inc.
Tel
+86-512-86881668
Fax
+86-512-62956001
Country
China
ProdList
100
Advantage
58
Shanghai Arbor Chemical Co., Ltd.
Tel
021-60451683 15021268886
Fax
+86-21-60451682
Email
sales@arborchemical.com
Country
China
ProdList
896
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
15026594951
Fax
0556-5030632
Email
rs@raise-chem.com
Country
China
ProdList
4454
Advantage
55
Valiant Co., Ltd.
Tel
0535-6101880
Fax
0535-6386989
Email
liutao@valiant-cn.com
Country
China
ProdList
292
Advantage
60
Aloespharm Co., Ltd.
Tel
021-20960837
Fax
021-20960837
Email
market@aloespharm.com
Country
China
ProdList
1302
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
027-27-81302488 15972195220
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
1758
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shandong Zhongke Taidou Chemical Co., Ltd.
Tel
0531-88682301 18595278760
Fax
0531-62325738
Email
sdzkzf@sdzktd.com
Country
China
ProdList
112
Advantage
62
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Jiaxing Novartis Chemical Co., Ltd.
Tel
18957373295
Fax
-
Country
China
ProdList
1580
Advantage
58
Wuhan Pengo Technology.,Ltd.
Tel
027-60707801 13628634921
Email
sunny.w@boronicgroup.com
Country
China
ProdList
156
Advantage
56
Shanghai SE Pharm Co., Ltd
Tel
18112588827
Email
sales4@sepharm.com.cn
Country
China
ProdList
285
Advantage
60
Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.
Tel
19943855286
Fax
0371-53392065
Email
triz-4@trizpharma.cn
Country
China
ProdList
1936
Advantage
56
Chengdu Laurelsci Tech Co., Ltd.
Tel
028-87983001
Fax
+86-28-86102331
Email
sales@laurelsci.com
Country
China
ProdList
50
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
BEIJING EAGLE SKY PHARMATECH CO., LTD
Tel
010-88755821 13911359480
Email
sophia_818@126.com
Country
China
ProdList
294
Advantage
55
Anqing CHICO Pharmaceutical Co., Ltd.
Tel
13585175604 13057662806
Fax
+86-25-52261140
Email
sales@chicopharm.com
Country
China
ProdList
500
Advantage
65
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3341
Advantage
55
shandong XuanHong Pharmaceutical Technology Co.,Ltd
Tel
+86-0531-88801869 15090917080
Fax
0531-88801867
Email
sciencechem@163.com
Country
China
ProdList
293
Advantage
55
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9287
Advantage
55
Shandong Xuande Pharmaceutical Technology Co. LTD
Tel
18866895588
Fax
0531-82777287
Email
dingjiaying@shiningpharm.com
Country
China
ProdList
163
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
2267
Advantage
55
Nanjing Ally Chemical S&T Co., Ltd.
Tel
025-025-58367986 18913956109
Fax
QQ:3209878052
Email
amy.xiang@ally-chem.com
Country
China
ProdList
568
Advantage
58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
7218
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
10410
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
More
Less

View Lastest Price from 4-Amino-2-hydroxy-5-methylpyridine manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
4-Amino-5-methylpyridin-2-ol 95306-64-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-26
Wuhan Biocar Pharmacy CO.,Ltd.
Product
4-AMino-5-Methylpyridin-2-ol 95306-64-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
800kg
Release date
2025-03-11
Zison Pharmaceutical (Shandong) Co., Ltd.
Product
4-Amino-2-hydroxy-5-methylpyridine 95306-64-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% by HPLC
Supply Ability
100kg/month
Release date
2023-01-05

95306-64-2, 4-Amino-2-hydroxy-5-methylpyridineRelated Search:

4-AMino-5-benzyl-pyriMidine-2-thiol

  • 4-amino-5-methylpyridine-2(1H)-one
  • 4-Amino-2-hydroxy-5-methylpyridine
  • 4-AMino-5-Methyl-2-(1H)-pyridinone
  • 4-AMino-5-Methylpyridin-2(1H)-one
  • 4-AMino-5-Methylpyridin-2-ol
  • 2(1H)-Pyridinone, 4-amino-5-methyl-
  • 4-amino-5-methyl-1H-pyridin-2-one
  • 4-amino-5-methylpyridone
  • 4-amino-5-methyl-1,2-dihydropyridin-2-one
  • Finerenone Impurity 28
  • 4-Amino-5-methyl-2-hydroxypyridine
  • 4-amino-5-methylpyridine-2(1H)-on
  • 4-Amino-5-methyl-2(1H)-pyridinone (4-Amino-5-methyl-2-pyridinol)
  • 4-Amino-5-methylpyridine-2-ol
  • Finerenone intermediate
  • 4-AMino-5-Methylpyridin-2Chemicalbook(1H)-one
  • Finerenone Impurity A
  • Degarelix Impurity 4
  • Felodipine Impurity 14
  • 4-Amino-5-Methylpyridin-2(1H)-One 4--5--2-
  • 95306-64-2
  • Intermediate
  • 95306-64-2