4-AMino-5-Methylpyridin-2-ol

Product Name: 4-AMino-5-Methylpyridin-2-ol
CAS No.: 95306-64-2
Chemical Name: 4-AMino-5-Methylpyridin-2-ol
Synonyms: 4-AMino-5-Methylpyridin-2(1H)-one;4-amino-5-methyl-1H-pyridin-2-one;4-Amino-2-hydroxy-5-methylpyridine;Degarelix Impurity 4;Finerenone Impurity A;Finerenone Impurity 28;Felodipine Impurity 14;Finerenone intermediate;4-amino-5-methylpyridone;4-AMino-5-Methylpyridin-2-ol
CBNumber: CB02507291
Molecular Formula: C6H8N2O
Formula Weight: 124.14
MOL File: 95306-64-2.mol

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4-AMino-5-Methylpyridin-2-ol Property

Boiling point:: 291.0±33.0℃ (760 Torr)
Density: 1.137±0.06 g/cm3 (20 ºC 760 Torr)
vapor pressure: 0-0Pa at 20-50℃
Flash point:: 129.8±25.4℃
storage temp.: 2-8°C(protect from light)
pka: 11.90±0.10(Predicted)
InChI: InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9)
InChIKey: SSQZBQXJYGNUSC-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(C)C(N)=C1
LogP: -0.51 at 20℃ and pH6.3
CAS DataBase Reference: 95306-64-2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A617510
Product name: 4-Amino-5-methylpyridin-2(1H)-one
Packaging: 1g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA16237
Product name: 4-Amino-5-methyl-2(1H)-pyridinone
Packaging: 2g
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-W022074
Product name: 4-Amino-5-methylpyridin-2-ol
Purity: ≥98.0%
Packaging: 5g
Price: $260
Updated: 2021/12/16

ChemScene

Product number: CS-W022074
Product name: 4-Amino-5-methylpyridin-2-ol
Purity: ≥98.0%
Packaging: 1g
Price: $63
Updated: 2021/12/16

AK Scientific

Product number: CS-W022074
Product name: 4-Amino-5-methylpyridin-2-ol
Packaging: 1g
Price: $80
Updated: 2021/12/16

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4-AMino-5-Methylpyridin-2-ol Chemical Properties,Usage,Production

Description

4-AMino-5-Methylpyridin-2-ol belongs to the pyridine derivatives and is significantly alkaline. Its alcoholic hydroxyl group can undergo corresponding nucleophilic substitution reactions under alkaline conditions. It can be used as a material in organic synthesis and medicinal chemistry. The intermediate is used for the modification and production of drug molecules. For example, the compound can prepare selective mineralocorticoid receptor (MR) antagonist finerenone, which is used to lower the risk of severe kidney and heart problems.

Uses

4-Amino-5-methylpyridin-2(1H)-one has been used as a reactant for the synthesis of BAY 94-8862, a nonsteroidal antagonist of the mineralocorticoid receptor to be used for the treatment of cardiorenal diseases.

Synthesis

2-Chloro-4-amino-5-methylpyridine, dissolved in ethylene glycol, could be a starting material to synthesize 4-AMino-5-Methylpyridin-2-ol. The crude product could be precipitated by adding hydrochloric acid/methanol solution.

4-AMino-5-Methylpyridin-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMino-5-Methylpyridin-2-ol Suppliers

China 261 Germany 1 India 12 United Kingdom 1 United States 7 Global 282

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View Lastest Price from 4-AMino-5-Methylpyridin-2-ol manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: 4-Amino-2-hydroxy-5-methylpyridine 95306-64-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥98% by HPLC
Supply Ability: 100kg/month
Release date: 2023-01-05

Nanjing Fred Technology Co., Ltd

Product: 4-Amino-2-hydroxy-5-methylpyridine 95306-64-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-04

Shanghai Yongzeng Technology Co.,Ltd

Product: 4-Amino-2-hydroxy-5-methylpyridine 95306-64-2
Price: US $0.00/gm
Min. Order: 100gm
Purity: 99%min
Supply Ability: 100kgs
Release date: 2024-09-04

95306-64-2, 4-AMino-5-Methylpyridin-2-olRelated Search:

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4-amino-5-methylpyridine-2(1H)-one

4-Amino-2-hydroxy-5-methylpyridine

4-AMino-5-Methyl-2-(1H)-pyridinone

4-AMino-5-Methylpyridin-2(1H)-one

4-AMino-5-Methylpyridin-2-ol

2(1H)-Pyridinone, 4-amino-5-methyl-

4-amino-5-methyl-1H-pyridin-2-one

4-amino-5-methylpyridone

4-amino-5-methyl-1,2-dihydropyridin-2-one

Finerenone Impurity 28

4-Amino-5-methyl-2-hydroxypyridine

4-amino-5-methylpyridine-2(1H)-on

4-Amino-5-methyl-2(1H)-pyridinone (4-Amino-5-methyl-2-pyridinol)

4-Amino-5-methylpyridine-2-ol

Finerenone intermediate

4-AMino-5-Methylpyridin-2Chemicalbook(1H)-one

Felodipine Impurity 14

Finerenone Impurity A

Degarelix Impurity 4

95306-64-2

Intermediate

95306-64-2