methyl 2-(4-bromo-2-fluorophenyl)acetate

Product Name: methyl 2-(4-bromo-2-fluorophenyl)acetate
CAS No.: 193290-19-6
Chemical Name: methyl 2-(4-bromo-2-fluorophenyl)acetate
Synonyms: Methyl 2-(4-bromo-2-fluorophenyl);Methyl 4-bromo-2-fluorophenylacetate;methyl 2-(4-bromo-2-fluorophenyl)acetate;Methyl 4-broMo-2-fluorophenylacetate, 96%;4-bromo-2-fluorophenylacetic acid methyl ester;Benzeneacetic acid, 4-bromo-2-fluoro-, methyl ester
CBNumber: CB02512895
Molecular Formula: C9H8BrFO2
Formula Weight: 247.06
MOL File: 193290-19-6.mol

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methyl 2-(4-bromo-2-fluorophenyl)acetate Property

Boiling point:: 265.4±25.0 °C(Predicted)
Density: 1.519±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: Solid
Appearance: Colorless to light yellow Liquid
CAS DataBase Reference: 193290-19-6

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Safety

HS Code: 2918300090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Oakwood

Product number: 242760
Product name: Methyl 2-(4-Bromo-2-fluorophenyl)acetate
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: 0015AB
Product name: Methyl2-(4-Bromo-2-fluorophenyl)acetate
Packaging: 1g
Price: $128
Updated: 2021/12/16

AK Scientific

Product number: 0015AB
Product name: Methyl2-(4-Bromo-2-fluorophenyl)acetate
Packaging: 10g
Price: $397
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0369096
Product name: METHYL-2-(4-BROMO-2-FLUOROPHENYL)ACETATE
Purity: 95.00%
Packaging: 5MG
Price: $500.78
Updated: 2021/12/16

Oakwood

Product number: 242760
Product name: Methyl 2-(4-Bromo-2-fluorophenyl)acetate
Packaging: 5g
Price: $210
Updated: 2021/12/16

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methyl 2-(4-bromo-2-fluorophenyl)acetate Chemical Properties,Usage,Production

Synthesis

67-56-1

114897-92-6

193290-19-6

The general procedure for the synthesis of methyl 2-fluoro-4-bromophenylacetate from methanol and 2-fluoro-4-bromophenylacetic acid was as follows: a mixture of 2-fluoro-4-bromophenylacetic acid (20.2 g, 86.6 mmol) and concentrated sulfuric acid (7 mL) in methanol (200 mL) was heated and refluxed for 18 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in dichloromethane (200 mL), washed sequentially with saturated sodium bicarbonate solution and brine, and the organic phase was dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give methyl 2-fluoro-4-bromophenylacetate (21.1 g, 99% yield) as a brown oil. Mass spectrum (ESI): m/z = 280.1 [M + H]+.

References

[1] Patent: WO2017/108723, 2017, A2. Location in patent: Page/Page column 225; 226
[2] Patent: US2014/194383, 2014, A1. Location in patent: Paragraph 0386-0388; 0390
[3] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 54; 55
[4] Patent: WO2016/38519, 2016, A1. Location in patent: Page/Page column 36; 37
[5] Patent: WO2016/38552, 2016, A1. Location in patent: Page/Page column 51

methyl 2-(4-bromo-2-fluorophenyl)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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methyl 2-(4-bromo-2-fluorophenyl)acetate Suppliers

China 41 India 2 United Kingdom 1 United States 5 Global 49

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methyl 2-(4-bromo-2-fluorophenyl)acetate

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193290-19-6