ChemicalBook > CAS DataBase List > MC1568

MC1568

Product Name
MC1568
CAS No.
852475-26-4
Chemical Name
MC1568
Synonyms
MC1568;CS-349;CS-2095;MC1568 ，S1484;MC 1568, >=98%;MC 1568;MC-1568;MC1568 USP/EP/BP;MC1568, 10 mM in DMSO;MC1568;MC 1568;MC-1568;3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
CBNumber
CB02517946
Molecular Formula
C17H15FN2O3
Formula Weight
314.31
MOL File
852475-26-4.mol
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MC1568 Property

Melting point:
212-215 °C(Solv: acetonitrile (75-05-8); methanol (67-56-1))
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
pka
8.91±0.23(Predicted)
form 
powder
color 
orange
InChIKey
QRDAPCMJAOQZSU-KQQUZDAGSA-N
CAS DataBase Reference
852475-26-4
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M1824
Product name
MC1568
Purity
≥97% (HPLC)
Packaging
5mg
Price
$217
Updated
2025/07/31
Sigma-Aldrich
Product number
M1824
Product name
MC1568
Purity
≥97% (HPLC)
Packaging
25mg
Price
$865
Updated
2025/07/31
Cayman Chemical
Product number
16265
Product name
MC 1568
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16265
Product name
MC 1568
Purity
≥95%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
16265
Product name
MC 1568
Purity
≥95%
Packaging
10mg
Price
$139
Updated
2024/03/01
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MC1568 Chemical Properties,Usage,Production

Description

While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling. Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology. MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1. It has been used in cells (1-10 μM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.

Uses

While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling. Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology. MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1. It has been used in cells (1-10 μM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.[Cayman Chemical]

Uses

A selective class II (IIa) histone deacetylase (HDAC II) inhibitor. It exhibits tissue-selective inhibition between members of class II acetylases in vivo, particularly in skeletal muscle and the heart. It arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex.

Definition

ChEBI: 3-[4-[3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methyl-2-pyrrolyl]-N-hydroxy-2-propenamide is a carbonyl compound.

Biochem/physiol Actions

MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor.

storage

+4°C

References

[1] ANTONELLO MAI. Class II (IIa)-Selective Histone Deacetylase Inhibitors. 1. Synthesis and Biological Evaluation of Novel (Aryloxopropenyl)pyrrolyl Hydroxyamides[J]. Journal of Medicinal Chemistry, 2005, 48 9: 3344-3353. DOI: 10.1021/jm049002a
[2] ANTONELLO MAI. Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia.[J]. Molecular Pharmacology, 2007, 72 5: 1111-1123. DOI: 10.1124/mol.107.036772
[3] ANGELA NEBBIOSO. Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.[J]. EMBO Reports, 2009, 10 7: 776-782. DOI: 10.1038/embor.2009.88
[4] VANESSA DUONG. Specific activity of class II histone deacetylases in human breast cancer cells.[J]. Molecular Cancer Research, 2008, 6 12: 1908-1919. DOI: 10.1158/1541-7786.mcr-08-0299
[5] ANGELA NEBBIOSO. HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation.[J]. Journal of molecular endocrinology, 2010, 45 4: 219-228. DOI: 10.1677/jme-10-0043
[6] GUAN WANG. Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer.[J]. PLoS ONE, 2012: e52095. DOI: 10.1371/journal.pone.0052095
[7] INGE MANNAERTS. Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29.[J]. PLoS ONE, 2013: e55786. DOI: 10.1371/journal.pone.0055786
[8] FRANCESCO SPALLOTTA. Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia.[J]. The Journal of Biological Chemistry, 2013, 288 32: 22915-22929. DOI: 10.1074/jbc.m113.484337

MC1568 Preparation Products And Raw materials

Raw materials

Preparation Products

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MC1568 Suppliers

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View Lastest Price from MC1568 manufacturers

Career Henan Chemical Co
Product
MC1568 852475-26-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

852475-26-4, MC1568Related Search:

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  • 3-[4-(3-(3-Fluorophenyl)-3-oxo-1-propen-1-yl)-1-Methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenaMide
  • (E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide
  • 3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide MC1568
  • MC 1568 3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
  • (E)-3-(5-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide
  • 3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
  • MC 1568, >=98%
  • (E)-3-(5-((E)-3-(3-fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide
  • (E)-3-(4-((E)-3-(3-Fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacryla
  • MC1568
  • 3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
  • MC 1568;MC-1568
  • CS-2095
  • CS-349
  • MC1568;MC 1568;MC-1568
  • (E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide
  • 2-Propenamide, 3-[5-[(1E)-3-(3-fluorophenyl)-3-oxo-1-propen-1-yl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-, (2E)-
  • MC1568 USP/EP/BP
  • MC1568, 10 mM in DMSO
  • MC1568 ，S1484
  • 852475-26-4
  • Inhibitor
  • Aromatics
  • API
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Selective inhibitor of class II (IIa) histone deacetylase (HDAC).