Ethyl 4-Ethynylbenzoate
- Product Name
- Ethyl 4-Ethynylbenzoate
- CAS No.
- 10602-03-6
- Chemical Name
- Ethyl 4-Ethynylbenzoate
- Synonyms
- Ethyl 4-Ethynylbenzoate;Ethyl 4-Ethynylbenzoate(WX686207);4-(Ethoxycarbonyl)phenylacetylene;(p-Ethoxycarbonylphenyl)acetylene;4-Ethynyl-benzoic acid ethyl ester;Ethyl 4-ethynylbenzoate - [E54339];Benzoic acid, 4-ethynyl-, ethyl ester
- CBNumber
- CB02518211
- Molecular Formula
- C11H10O2
- Formula Weight
- 174.2
- MOL File
- 10602-03-6.mol
Ethyl 4-Ethynylbenzoate Property
- Melting point:
- 28 °C
- Boiling point:
- 257.1±23.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow <28 °C Solid,>28 °C Liquid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- E1501
- Product name
- Ethyl 4-Ethynylbenzoate
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $112
- Updated
- 2025/07/31
- Product number
- E1501
- Product name
- Ethyl 4-Ethynylbenzoate
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $336
- Updated
- 2025/07/31
- Product number
- 449259
- Product name
- Ethyl 4-ethynylbenzoate
- Packaging
- 10mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- E917888
- Product name
- Ethyl4-ethynylbenzoate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR951484
- Product name
- Ethyl 4-ethynylbenzoate
- Packaging
- 100mg
- Price
- $135
- Updated
- 2021/12/16
Ethyl 4-Ethynylbenzoate Chemical Properties,Usage,Production
Synthesis
150969-54-3
10602-03-6
The general procedure for the synthesis of ethyl 4-alkynylbenzoate from the compound (CAS:150969-54-3) is as follows: firstly, the desired aryl-substituted terminal acetylene (5) was prepared using the Sonogashira reaction [1] as a precursor for the synthesis of betulinic acid 1,2,3-triazole library. Some of the acetylene (5a, 5b, 5c, 5g) can be purchased directly from commercial sources. This was done as follows: under argon protection, iodide 6 (500 mg) was reacted with trimethylmethylsilylacetylene (1.5 eq.) in the presence of Pd(PPh3)2Cl2 (2 mol%), CuI (4 mol%), and triethylamine (0.5 mL) in dry DMF at room temperature to produce intermediate 7. Subsequently, intermediate 7 was formed by reaction of iodide 6 with trimethylsilylacetylene (1.5 eq.) dissolved in anhydrous methanol (4.0 mL ) in anhydrous methanol (4.0 mL), the demethylsilylation reaction was achieved by treating intermediate 7 with a solution of K2CO3 (1 equiv.) to ultimately yield terminal acetylene 5.
References
[1] Chemistry - A European Journal, 2011, vol. 17, # 34, p. 9320 - 9325
[2] European Journal of Medicinal Chemistry, 2015, vol. 102, p. 93 - 105
[3] Patent: WO2009/149381, 2009, A2. Location in patent: Page/Page column 32
[4] Journal of Polymer Science, Part A: Polymer Chemistry, 2011, vol. 49, # 1, p. 211 - 224
[5] Journal of the American Chemical Society, 2015, vol. 137, # 1, p. 413 - 419
Ethyl 4-Ethynylbenzoate Preparation Products And Raw materials
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View Lastest Price from Ethyl 4-Ethynylbenzoate manufacturers
- Product
- Ethyl 4-Ethynylbenzoate 10602-03-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25