4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate

Product Name: 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
CAS No.: 15427-93-7
Chemical Name: 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
Synonyms: DDUG diMS;NSC 109555;NSC109555 Dimesylate;NSC 109555 ditosylate;DDUG dimethanesulfonate;4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate;2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2)
CBNumber: CB02518817
Molecular Formula: C20H28N10O4S
Formula Weight: 504.56592
MOL File: 15427-93-7.mol

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4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Property

storage temp.: 2-8°C
solubility: H2O: soluble5mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0781
Product name: NSC109555
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $95.7
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML0781
Product name: NSC109555
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $377
Updated: 2022/05/15

Cayman Chemical

Product number: 19811
Product name: NSC 109555
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 19811
Product name: NSC 109555
Packaging: 5mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 19811
Product name: NSC 109555
Packaging: 10mg
Price: $140
Updated: 2024/03/01

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4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Chemical Properties,Usage,Production

Uses

NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death.

Biochem/physiol Actions

NSC109555 is a selective inhibitor of Chk2 (IC50 = 310 nM). The compound is reversible and competitive for ATP, and displays little or no activity against other related kinases, including Chk1, at concentrations up to 10 μM.

4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Suppliers

Canada 1 CHINA 32 United Kingdom 2 United States 5 USA 1 Global 41

Toronto Research Chemicals

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15427-93-7, 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylateRelated Search:

NSC 109555

2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2)

NSC109555 Dimesylate

4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate

NSC 109555 ditosylate

DDUG dimethanesulfonate

DDUG diMS

15427-93-7

C19H24N10O2C7H8O3S