ChemicalBook > CAS DataBase List > 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
- Product Name
- 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
- CAS No.
- 15427-93-7
- Chemical Name
- 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
- Synonyms
- DDUG diMS;NSC 109555;NSC109555 Dimesylate;NSC 109555 ditosylate;DDUG dimethanesulfonate;4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate;2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2)
- CBNumber
- CB02518817
- Molecular Formula
- C20H28N10O4S
- Formula Weight
- 504.56592
- MOL File
- 15427-93-7.mol
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4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Property
- storage temp.
- 2-8°C
- solubility
- H2O: soluble5mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0781
- Product name
- NSC109555
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $95.7
- Updated
- 2022/05/15
Sigma-Aldrich
- Product number
- SML0781
- Product name
- NSC109555
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $377
- Updated
- 2022/05/15
Cayman Chemical
- Product number
- 19811
- Product name
- NSC 109555
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19811
- Product name
- NSC 109555
- Packaging
- 5mg
- Price
- $84
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19811
- Product name
- NSC 109555
- Packaging
- 10mg
- Price
- $140
- Updated
- 2024/03/01
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4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Chemical Properties,Usage,Production
Uses
NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death.
Biochem/physiol Actions
NSC109555 is a selective inhibitor of Chk2 (IC50 = 310 nM). The compound is reversible and competitive for ATP, and displays little or no activity against other related kinases, including Chk1, at concentrations up to 10 μM.
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Preparation Products And Raw materials
Raw materials
Preparation Products
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