N-Ethyl-p-menthane-3-carboxamide

Product Name: N-Ethyl-p-menthane-3-carboxamide
CAS No.: 39711-79-0
Chemical Name: N-Ethyl-p-menthane-3-carboxamide
Synonyms: WS-3;Menthol Carboxamide;ETHYL MENTHANE CARBOXAMIDE;Cooling Agent WS-3;N,2,3-trimethyl-2isopropl butanamide;FEMA 3455;Cooling taste agent ws-23;N-Ethyl-PARA-Menthan-3-Carboxamide;N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE;N-Ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
CBNumber: CB0252522
Molecular Formula: C13H25NO
Formula Weight: 211.34
MOL File: 39711-79-0.mol

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N-Ethyl-p-menthane-3-carboxamide Property

Melting point:: 87-102 °C
alpha: D -49 to -54°
Boiling point:: 351.04°C (rough estimate)
Density: 0.9305 (rough estimate)
vapor pressure: 0.007Pa at 25℃
refractive index: 1.4410 (estimate)
FEMA: 3455 | N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: ≥ 100 mg/mL (473.17 mM); Water: < 0.1 mg/mL (insoluble)
pka: 16.27±0.60(Predicted)
form: powder to crystal
color: White to Almost white
Odor: at 25.00 % in dipropylene glycol. mild mentholic minty
Odor Type: minty
biological source: synthetic
Water Solubility: insoluble
Merck: 14,3825
JECFA Number: 1601
InChIKey: VUNOFAIHSALQQH-UHFFFAOYSA-N
LogP: 2.902 at 25℃
CAS DataBase Reference: 39711-79-0(CAS DataBase Reference)
EPA Substance Registry System: Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)- (39711-79-0)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36-41-22
Safety Statements: 39-26
WGK Germany: 2
HS Code: 29242990
Toxicity: LD50 in mice, rats (g/kg): 5.3, 2.9 orally (Parrish)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W345501
Product name: N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity: 99%, FG
Packaging: 1 unit
Price: $53.48
Updated: 2025/07/31

Sigma-Aldrich

Product number: W345501
Product name: N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity: 99%, FG
Packaging: 1 unit
Price: $53.48
Updated: 2025/07/31

Sigma-Aldrich

Product number: W345501
Product name: N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity: 99%, FG
Packaging: 100g
Price: $141.55
Updated: 2025/07/31

Sigma-Aldrich

Product number: W345501
Product name: N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity: 99%, FG
Packaging: 1kg
Price: $690
Updated: 2025/07/31

Sigma-Aldrich

Product number: W345501
Product name: N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity: 99%, FG
Packaging: 5kg
Price: $1460
Updated: 2025/07/31

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N-Ethyl-p-menthane-3-carboxamide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Chemical Properties

N-ethyl-p-menthane-3-carboxamide is an odorless white, crystalline solid. The compound has a strong and clear physiological cooling effect and is used mainly in oral care products.

Chemical Properties

Slight menthol-like cooling effect aroma

Uses

Physiological coolant in foods, beverages, toiletries, cosmetics and pharmaceuticals.

Uses

N-Ethyl-p-menthane-3-carboxamide is a selective transient receptor potential melastatin-8 ligand.

Definition

ChEBI: Ethyl menthane carboxamide is a p-menthane monoterpenoid.

Aroma threshold values

Aroma characteristics at 1.0%. Virtually odorless

Taste threshold values

Taste characteristics at 10 to 100 ppm. Intense lingering cooling. The cooling sensation builds slow but steadily and grows to a lingering cooling mouthfeel with a slightly camphoraceous and minty character.

Flammability and Explosibility

Not classified

Trade name

Winsense WS-3 (Renessenz)

Biological Activity

Cooling agent that is an agonist at TRPM8 receptors (EC 50 = 3.7 μ M).

Synthesis

0.89 g (0.0091 mol) of polyphosphoric acid (85%) and 0.42 g (0.0091 mol) of ethanol were weighed. 0.54 g (0.0046 mol) of diethylcarbonate was added dropwise slowly while cooling in an ice bath, wherein the temperature increases slightly. After about 5 minutes, 0.5 g (0.0030 mol) of p-menthane-3-carbonitrile was added. The reaction solution was heated and stirred for 102 hours at 150??C. At the end of the reaction by GC, about 70% of desired N-Ethyl-p-menthane-3-carboxamide was formed.Fig The synthetic method 1 of N-Ethyl-p-menthane-3-carboxamide

N-Ethyl-p-menthane-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Ethyl-p-menthane-3-carboxamide Suppliers

Americas 2 Belgium 1 China 304 Europe 3 France 1 Germany 2 India 7 Japan 2 Switzerland 1 United Kingdom 4 United States 45 USA 1 Global 374

Ji'an Guoguang spice factory

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J & K SCIENTIFIC LTD.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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TCI (Shanghai) Development Co., Ltd.

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Beijing HwrkChemical Technology Co., Ltd

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View Lastest Price from N-Ethyl-p-menthane-3-carboxamide manufacturers

Changsha Hongyuxiang Chemical Co., Ltd

Product: cooling agent 39711-79-0
Price: US $0.00/kg
Min. Order: 100kg
Purity: 99.5%-99.9%
Supply Ability: 2000Tons
Release date: 2025-07-15

Hebei Fengjia New Material Co., Ltd

Product: N-Ethyl-p-menthane-3-carboxamide 39711-79-0
Price: US $5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000
Release date: 2024-09-04

Hebei Chuanghai Biotechnology Co., Ltd

Product: N-Ethyl-p-menthane-3-carboxamide 39711-79-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-19

39711-79-0, N-Ethyl-p-menthane-3-carboxamideRelated Search:

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TIMTEC-BB SBB008527

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N-Ethyl-p-menthane-3-carboxamide&gt

N-Ethyl-p-menthane-3-carboxamide（Cooling taste agent WS-23）

-p-menthane-3-carboxamide

N-Ethyl-p-menthane-3-carboxamide ISO 9001：2015 REACH

Cool taste WS - 3

N-ETHYL-P-MENTHAN-3-CARBOXAMIDE(WS-3)

N-Ethyl-2-isopropyl-5-methylcyclohexane ? ?carboxamide(WS-3)

(1R,2S,5R)-N-Ethyl-p-menthane-3-carboxamide

N-Ethyl-p-menthane-3-carboxamide (WS-3)

TRPM8 antagonist WS-3, 10 mM in DMSO

N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide

39711-79-0