ChemicalBook > CAS DataBase List > N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

Product Name
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
CAS No.
444731-75-3
Chemical Name
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
Synonyms
BNKY007-PZ02;Pazopanib Impurity 22;Pazopanib intermediate;Pazopanib ( PAZ ) N - Methyl compound;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amin...
CBNumber
CB02526159
Molecular Formula
C14H14ClN5
Formula Weight
287.75
MOL File
444731-75-3.mol
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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Property

Melting point:
167-173℃
Boiling point:
524.4±35.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
pka
2.82±0.30(Predicted)
Stability:
Hygroscopic
CAS DataBase Reference
444731-75-3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H33611
Product name
6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole, 96%
Packaging
500mg
Price
$102
Updated
2023/06/20
TRC
Product number
C380090
Product name
N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine
Packaging
1g
Price
$155
Updated
2021/12/16
TRC
Product number
C380090
Product name
N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine
Packaging
10g
Price
$1210
Updated
2021/12/16
Matrix Scientific
Product number
139007
Product name
N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
Purity
95%+
Packaging
1g
Price
$1554
Updated
2021/12/16
Matrix Scientific
Product number
139007
Product name
N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
Purity
95%+
Packaging
2.500g
Price
$3386
Updated
2021/12/16
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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Chemical Properties,Usage,Production

Chemical Properties

Light Beige to Beige Solid

Uses

N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Synthesis

A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Suppliers

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View Lastest Price from N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine manufacturers

Nanjing Fred Technology Co., Ltd
Product
N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine 444731-75-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
ton
Release date
2023-11-15
Henan Fengda Chemical Co., Ltd
Product
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 444731-75-3
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-26
Henan Fengda Chemical Co., Ltd
Product
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 444731-75-3
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-26

444731-75-3, N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMineRelated Search:

5-BROMO-3-METHYLINDOLE 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) 1,3-DiMethyl-6-aMino-1H-indazole 4(1H)-Pyrimidinone, 2-chloro- (9CI) 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib-d6 2,3-dimethyl-2H-indazol-6-amine hydrochloride Pazopanib Impurity 9 Pazopanib Pazopanib Related Compound 2 1,3-Dimethyl-6-nitro-1H-indazole Pazopanib Related Compound 3 3-Methyl-6-nitro-2H-indazole 4-Acetoxy-3-acetoxymethylacetophenone (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Pazopanib Impurity 10

  • 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazol-6-amine
  • BNKY007-PZ02
  • 2H-indazole-6-aMine，N-(2-chloro -4-pyrimidinyl)-N,2,3-trimethyl-
  • Pazopanib Impurity 22
  • N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine
  • N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
  • N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine
  • 2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-
  • 6-[N-(2-chloro-4-pyriMidinyl)MethylaMino]-2,3-diMethyl-2H-indazole, 96%
  • N-(2-ChloropyriMidin-4-yl)-N-Methyl-2,3-diMethyl-2H-indazol-6-aMine
  • N-(2- chloropyrimidine-4- group)- N- methyl-2,3-dimethyl-2 H- indazole-6-amine
  • 6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole,96%
  • N-(2-chloropyrimidine-4-yl) -N-methyl-2, 3-dimethyl-2H-indazol-6-amine
  • Pazopanib intermediate
  • N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine
  • N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine ISO 9001：2015 REACH
  • (2-Chloro-pyrimidin-4-yl)-(2,3-dimethyl-2H-indazol-6-yl)-methyl-amine
  • N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amin...
  • TIANFU-CHEM - N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
  • Pazopanib ( PAZ ) N - Methyl compound
  • 444731-75-3
  • 44731-75-3