ChemicalBook > CAS DataBase List > N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

Product Name
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
CAS No.
444731-75-3
Chemical Name
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
Synonyms
BNKY007-PZ02;Pazopanib Impurity 22;Pazopanib Impurity 34;Pazopanib intermediate;Pazopanib ( PAZ ) N - Methyl compound;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-
CBNumber
CB02526159
Molecular Formula
C14H14ClN5
Formula Weight
287.75
MOL File
444731-75-3.mol
More
Less

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Property

Melting point:
167-173℃
Boiling point:
524.4±35.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
pka
2.82±0.30(Predicted)
Stability:
Hygroscopic
CAS DataBase Reference
444731-75-3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Alfa Aesar
Product number
H33611
Product name
6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole, 96%
Packaging
500mg
Price
$102
Updated
2023/06/20
TRC
Product number
C380090
Product name
N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine
Packaging
1g
Price
$155
Updated
2021/12/16
TRC
Product number
C380090
Product name
N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine
Packaging
10g
Price
$1210
Updated
2021/12/16
Matrix Scientific
Product number
139007
Product name
N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
Purity
95%+
Packaging
1g
Price
$1554
Updated
2021/12/16
Matrix Scientific
Product number
139007
Product name
N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
Purity
95%+
Packaging
2.500g
Price
$3386
Updated
2021/12/16
More
Less

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Chemical Properties,Usage,Production

Chemical Properties

Light Beige to Beige Solid

Uses

N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Synthesis

A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Suppliers

Canada 1 China 172 India 15 Ukraine 1 United Kingdom 1 United States 7 Global 197
Jiaxing Triview Biochemical Products Co., Ltd.
Tel
0573-0573-87228088 17772796899
Fax
0573-87228088
Email
triview@triviewbiochem.com
Country
China
ProdList
17
Advantage
58
Yangzhou QinYuan Pharmaceutical Co., Ltd.
Tel
0514-80939770 13773367191
Fax
0514-82664689
Email
yzqyyykj@163.com
Country
China
ProdList
240
Advantage
55
Shanghai Runtai Pharmaceutical Technology Co., LTD
Tel
152-6236-2504 18019700392
Fax
QQ3572097758
Email
clong008@163.com
Country
China
ProdList
117
Advantage
58
Beijing Stronger Science Co., Ltd.
Tel
0531-88924771 15614660963
Email
elsa.hang@strongerscience.com
Country
China
ProdList
10623
Advantage
58
Jinan Dexinjia Bio&Tech Co., Ltd
Tel
0531-82375886 13001715031
Fax
0531-82375893
Email
3517280075@qq.com
Country
China
ProdList
1312
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
HuiFeiChem(WuXi) PharmaTech Co.,Ltd
Tel
0510-0510-83593305
Fax
0086-510-83593305
Email
sales@huifeichem.com
Country
China
ProdList
104
Advantage
62
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7191
Advantage
65
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9459
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Shenzhen HwaGen Pharmaceutical Co.,Ltd
Tel
18927339850
Fax
0752-5319394
Email
xiaodong.shi@rafflespt.com
Country
China
ProdList
237
Advantage
58
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-021-36680027 15800370750
Email
1706640024@qq.com
Country
China
ProdList
540
Advantage
56
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3991
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10276
Advantage
55
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5806
Advantage
50
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-66023220 0086-15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7850
Advantage
55
Intelligence Pharm Science(Shanghai) Co., Ltd.
Tel
021-57898186
Fax
021-37699262
Country
China
ProdList
449
Advantage
55
Anqing CHICO Pharmaceutical Co., Ltd.
Tel
18061456370 18951649510
Fax
+86-25-52261140
Email
sales@chicopharm.com
Country
China
ProdList
443
Advantage
65
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
Advantage
55
Taizhou Ruixin Chemical Co., Ltd.
Tel
0576-89085261 15867635987
Fax
0576-89085262
Email
jasonhu09@163.com
Country
China
ProdList
442
Advantage
50
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
Nanjing XiLang Chemical Products Co., Ltd.
Tel
18936048580
Email
chemxilang@163.com
Country
China
ProdList
3994
Advantage
58
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Suzhou JingTong Pharmaceutical Co., Ltd.
Tel
13675155016
Fax
18912765016
Email
tongtf110@sina.com
Country
China
ProdList
963
Advantage
55
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9204
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Shanghai Pingguo Pharmaceutical Co., Ltd.
Tel
021-20432229
Fax
QQ2412110556
Email
2412110556@qq.com
Country
China
ProdList
6017
Advantage
55
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-50664929, 13971561712
Fax
027-50664927 / QQ: 3452835437
Email
hubxys2001@163.com
Country
China
ProdList
1437
Advantage
55
Nanjing Klender Bio-Technology Co., Ltd.
Tel
025-52343882 18112933882
Fax
025-52343882
Email
sales@kldbio.com
Country
China
ProdList
2019
Advantage
55
Guangzhou Jhd Chemical Reagent Co., Ltd.
Tel
020-84383047
Fax
020-84380294
Email
sales@jhd.com.cn
Country
China
ProdList
9186
Advantage
65
BIO-PHARMACY (Wuhan) Co., Ltd.
Tel
0711-5919292 15307133740
Fax
0711-5919292
Email
3451683016@qq.com
Country
China
ProdList
1069
Advantage
58
Klong Industrial Co., Ltd
Tel
519-68231162 13961227312
Fax
0519-68231162
Email
info@klongchem.com
Country
China
ProdList
164
Advantage
58
Conier Chem & Pharma Limited
Tel
13368167990
Email
sales@conier.com
Country
China
ProdList
2830
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187 13917602471
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
China
ProdList
9897
Advantage
58
Alchemist-pharm chemical Technology Co. Ltd.
Tel
0371-67991738 13783628208
Fax
QQ 412703949
Email
carl@alchemist-pharm.com
Country
China
ProdList
1872
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Tianjin Zhongcheng Mingyuan Technology Co., Ltd.
Tel
13302022156
Fax
-
Email
3506745780@qq.com
Country
China
ProdList
174
Advantage
58
More
Less

View Lastest Price from N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine manufacturers

Nanjing Fred Technology Co., Ltd
Product
N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine 444731-75-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
ton
Release date
2023-11-15
Hebei Zhuanglai Chemical Trading Co Ltd
Product
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 444731-75-3
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-13
Hebei Ganmiao New material Technology Co., LTD
Product
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 444731-75-3
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20ton
Release date
2024-06-06

444731-75-3, N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMineRelated Search:

5-BROMO-3-METHYLINDOLE 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) 1,3-DiMethyl-6-aMino-1H-indazole 4(1H)-Pyrimidinone, 2-chloro- (9CI) 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib-d6 2,3-dimethyl-2H-indazol-6-amine hydrochloride Pazopanib Impurity 9 Pazopanib Pazopanib Related Compound 2 1,3-Dimethyl-6-nitro-1H-indazole Pazopanib Related Compound 3 3-Methyl-6-nitro-2H-indazole 4-Acetoxy-3-acetoxymethylacetophenone (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Pazopanib Impurity 10

  • 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazol-6-amine
  • BNKY007-PZ02
  • 2H-indazole-6-aMine，N-(2-chloro -4-pyrimidinyl)-N,2,3-trimethyl-
  • Pazopanib Impurity 22
  • N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine
  • N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
  • N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine
  • 2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-
  • 6-[N-(2-chloro-4-pyriMidinyl)MethylaMino]-2,3-diMethyl-2H-indazole, 96%
  • N-(2-ChloropyriMidin-4-yl)-N-Methyl-2,3-diMethyl-2H-indazol-6-aMine
  • N-(2- chloropyrimidine-4- group)- N- methyl-2,3-dimethyl-2 H- indazole-6-amine
  • 6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole,96%
  • N-(2-chloropyrimidine-4-yl) -N-methyl-2, 3-dimethyl-2H-indazol-6-amine
  • Pazopanib intermediate
  • N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine
  • N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine ISO 9001：2015 REACH
  • (2-Chloro-pyrimidin-4-yl)-(2,3-dimethyl-2H-indazol-6-yl)-methyl-amine
  • N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amin...
  • TIANFU-CHEM - N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
  • Pazopanib ( PAZ ) N - Methyl compound
  • Pazopanib Impurity 34
  • N - (2-chloropyrimidin-4-yl) - N-methyl-2,3-methyl-2H-indazole-6-amine
  • 444731-75-3
  • 44731-75-3