2,3-dimethyl-2H-indazol-6-amine hydrochloride

Product Name: 2,3-dimethyl-2H-indazol-6-amine hydrochloride
CAS No.: 635702-60-2
Chemical Name: 2,3-dimethyl-2H-indazol-6-amine hydrochloride
Synonyms: 2,3-dimethylindazol-6-amine hydrochloride;PAZ20;Pazopanib Impurity 21;Pazopanib Impurity 7 HCl;2H-Indazol-6-amine,2,3-dimethy;2,3-Dimethyl-6-amino-2H-indazole Hy;2,3-Dimethyl-6-Amino-2H-Indazole HCl;Pazopanib Impurity 13(hydrochloride);2H-Indazol-6-ylamine,2,3-dimethyl-, HCl;6-amino-2,3-dimethylindazole hydrochloride
CBNumber: CB42503206
Molecular Formula: C9H12ClN3
Formula Weight: 197.66468
MOL File: 635702-60-2.mol

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2,3-dimethyl-2H-indazol-6-amine hydrochloride Property

Melting point:: >230°C (dec.)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Pale Beige to Light Beige
Stability:: Hygroscopic
InChI: InChI=1S/C9H11N3.ClH/c1-6-8-4-3-7(10)5-9(8)11-12(6)2;/h3-5H,10H2,1-2H3;1H
InChIKey: DYTQJZDNKWQSLS-UHFFFAOYSA-N
SMILES: N1=C2C(C=CC(N)=C2)=C(C)N1C.[H]Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm

Product number: P000723396
Product name: 2,3-Dimethyl-2H-indazol-6-amine hydrochloride
Purity: 97%
Packaging: 5g
Price: $26
Updated: 2021/12/16

Ark Pharm

Product number: P000723396
Product name: 2,3-Dimethyl-2H-indazol-6-amine hydrochloride
Purity: 97%
Packaging: 10g
Price: $44
Updated: 2021/12/16

Ark Pharm

Product number: P000723396
Product name: 2,3-Dimethyl-2H-indazol-6-amine hydrochloride
Purity: 97%
Packaging: 1g
Price: $21
Updated: 2021/12/16

Ark Pharm

Product number: P000723396
Product name: 2,3-Dimethyl-2H-indazol-6-amine hydrochloride
Purity: 97%
Packaging: 25g
Price: $79
Updated: 2021/12/16

AK Scientific

Product number: Z1741
Product name: 2,3-Dimethyl-2H-indazol-6-aminehydrochloride
Packaging: 5g
Price: $93
Updated: 2021/12/16

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2,3-dimethyl-2H-indazol-6-amine hydrochloride Chemical Properties,Usage,Production

Description

2,3-dimethyl-2H-indazol-6-amine hydrochloride is a pharmaceutical intermediate impurity, a by-product from the preparation of pazopanib hydrochloride, which can be used as an impurity standard solution for experimental analysis.

Chemical Properties

Powder

Uses

2,3-Dimethyl-6-amino-2H-indazole is an impurity in the synthesis of Pazopanib (P210925) hydrochloride, an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Synthesis

444731-73-1

635702-60-2

General procedure for the synthesis of 2,3-dimethyl-6-amino-2H-indazole hydrochloride from 2,3-dimethyl-6-nitroindazole: 2,3-dimethyl-6-nitro-2H-indazole (1.13 g) was dissolved in 2-methoxyethyl ether (12 mL) under stirring at 0°C, and then 4.48 g of stannous chloride in 8.9 mL of concentrated hydrochloric acid was added drop by drop over a period of 5 minutes solution. After the dropwise addition was completed, the ice bath was removed and the reaction mixture continued to be stirred for 30 minutes. Subsequently, about 40 mL of diethyl ether was added to the reaction solution to induce precipitation of the product. The precipitate was separated by filtration and washed with diethyl ether to afford the yellow solid product 2,3-dimethyl-6-amino-2H-indazole hydrochloride (1.1 g, 95% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6) and mass spectrometry (ES+): 1H NMR δ 7.77 (d, J=8.9Hz, 1H), 7.18 (s, 1H), 7.88 (m, 1H), 4.04 (s, 3H), 2.61 (s, 3H); MS (ES+, m/z) 162 (M+H).

References

[1] Patent: WO2003/106416, 2003, A2. Location in patent: Page 42-43
[2] Patent: WO2007/64753, 2007, A2. Location in patent: Page/Page column 27
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4632 - 4640
[4] Patent: WO2006/20564, 2006, A1. Location in patent: Page/Page column 14
[5] Patent: EP2311825, 2015, B1. Location in patent: Paragraph 0178 - 0180

2,3-dimethyl-2H-indazol-6-amine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-dimethyl-2H-indazol-6-amine hydrochloride Suppliers

China 232 India 11 United States 9 USA 1 Global 253

Yangzhou QinYuan Pharmaceutical Co., Ltd.

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China Synchem Technology Co.,Ltd.

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Shanghai T&W Pharmaceutical Co., Ltd.

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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

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View Lastest Price from 2,3-dimethyl-2H-indazol-6-amine hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,3-dimethyl-2H-indazol-6-amine hydrochloride 635702-60-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-21

Henan Aochuang Chemical Co.,Ltd.

Product: 2,3-dimethyl-2H-indazol-6-amine hydrochloride 635702-60-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Nanjing Fred Technology Co., Ltd

Product: 2,3-dimethyl-2H-indazol-6-amine hydrochloride 635702-60-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-19

635702-60-2, 2,3-dimethyl-2H-indazol-6-amine hydrochlorideRelated Search:

2,3-DIMETHYL-2H-INDAZOL-6-AMINE N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Pazopanib Related Compound 3 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) 1,3-Dimethyl-6-nitro-1H-indazole Pazopanib Related Compound 2 3-Methyl-6-nitro-2H-indazole Pazopanib 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE Pazopanib Hydrochloride 2-Ethyl-5-nitrobenzenamine ,98% Pazopanib Impurity 9 N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib Impurity 10 1,3-DiMethyl-6-aMino-1H-indazole Pazopanib Impurity 2 2-Methyl-5-nitrobenzenesulfonamide 3-AMINO-4-METHYLBENZENESULFONAMIDE

2,3-dimethyl-2H-indazol-6-amine hydrochloride

2,3-Dimethyl-2H-indazol-6-amine monohydrochloride

2,3-Dimethyl-6-amino-2H-indazole hydrochloride

2H-Indazol-6-aMine,2,3-diMethyl-, hydrochloride (1:1)

3-Methyl-6-nitro-1H-indazole hydrochloride

6-amino-2,3-dimethylindazole hydrochloride

Pazopanib Impurity 21

PAZ20

2H-Indazol-6-aMine,2,3-diMethyl-, hydrochloride

6-Amino-2,3-dimethyl-2H-indazole Hydrochloride

2,3-Dimethyl-2H-indazol-6-amine hydrochloride 2,3-Dimethyl-2H-indazol-6-amine monohydrochloride

2,3-Dimethyl-6-Amino-2H-Indazole HCl

2,3-dimethylindazol-6-amine hydrochloride

Pazopanib Impurity 7 HCl

3-diMethyl-2H-indazol-6-aMine hydrochloride

2,3-Dimethyl-6-amino-2H-indazole Hy

2,3-dimethyl-2H-indazol-6-amine hydrochloride ISO 9001：2015 REACH

2,3-Dimethyl-2H-indazole-6-amine hydrochloride

1-(2-Chloropyrimidin-4-yl)pyrimidine-2,4-dione

2,3-dimethyl-2H-Indazol-6-amine hydrochloride (1:1)

2H-Indazol-6-ylamine,2,3-dimethyl-, HCl

2H-Indazol-6-amine,2,3-dimethy

2,3-methyl-6-amino-2H-indazole hydrochloride

Pazopanib Impurity 13(hydrochloride)

635702-60-2