2-ethyl-5-nitroaniline
- Product Name
- 2-ethyl-5-nitroaniline
- CAS No.
- 20191-74-6
- Chemical Name
- 2-ethyl-5-nitroaniline
- Synonyms
- Pazopanib Impurity 53;Pazopanil Impurity 38;2-ethyl-5-nitroaniline;2-ethyl-5-nitrobenzenamine;2-Ethyl-5-nitro-phenylaMine;BenzenaMine, 2-ethyl-5-nitro-;4-Nitro-2-amino-1-ethylbenzene;2-Ethyl-5-nitrobenzenamine 98%;2-Ethyl-5-nitrobenzenamine ,98%;2-Ethyl-5-nitroaniline 2-Ethyl-5-nitrobenzenamine
- CBNumber
- CB12129191
- Molecular Formula
- C8H10N2O2
- Formula Weight
- 166.18
- MOL File
- 20191-74-6.mol
2-ethyl-5-nitroaniline Property
- Melting point:
- 63-64℃ (methanol )
- Boiling point:
- 335.3±22.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 2.25±0.10(Predicted)
- color
- Light yellow to Brown
- InChI
- InChI=1S/C8H10N2O2/c1-2-6-3-4-7(10(11)12)5-8(6)9/h3-5H,2,9H2,1H3
- InChIKey
- MMZWMCKTKJKIMC-UHFFFAOYSA-N
- SMILES
- C1(N)=CC([N+]([O-])=O)=CC=C1CC
- CAS DataBase Reference
- 20191-74-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S752118
- Product name
- 2-ETHYL-5-NITROANILINE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- S752118
- Product name
- 2-ETHYL-5-NITROANILINE
- Purity
- Aldrich
- Packaging
- 100mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- E1085
- Product name
- 2-Ethyl-5-nitroaniline
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $109
- Updated
- 2025/07/31
- Product number
- E1085
- Product name
- 2-Ethyl-5-nitroaniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $386
- Updated
- 2025/07/31
- Product number
- E925233
- Product name
- 2-Ethyl-5-nitrobenzenamine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
2-ethyl-5-nitroaniline Chemical Properties,Usage,Production
Chemical Properties
Yellow to light brown or brown solid
Synthesis
578-54-1
20191-74-6
General procedure for the synthesis of 2-ethyl-5-nitroaniline from 2-ethylaniline: 2-ethylaniline (24.2 g, 0.2 mol) was slowly added to concentrated sulfuric acid (100 mL), keeping the temperature of the reaction system lower than 0°C. The reaction was carried out at a controlled temperature. Fuming nitric acid (18.6 g, 0.3 mol) was slowly added dropwise under strictly controlled temperature conditions. After the dropwise addition, the reaction mixture was kept stirring at room temperature. Upon completion of the reaction, the reaction solution was carefully poured into ice water (1000 mL) and stirred while adding. Subsequently, the pH of the mixture was adjusted slowly by adding 50% sodium hydroxide solution to about 8. The precipitate was collected by filtration and the filter cake was recrystallized with petroleum ether to give 2-ethyl-5-nitroaniline (26.6 g, 80.1% yield) as a yellow needle-like solid.
References
[1] Patent: CN103373989, 2016, B. Location in patent: Paragraph 0031; 0032
[2] Patent: CN103739550, 2016, B. Location in patent: Paragraph 0125-0129
[3] Tetrahedron, 1990, vol. 46, # 17, p. 6085 - 6112
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4632 - 4640
[5] Patent: WO2009/62658, 2009, A1. Location in patent: Page/Page column 33; 1/10
2-ethyl-5-nitroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-ethyl-5-nitroaniline manufacturers
- Product
- 2-Ethyl-5-nitroaniline 20191-74-6
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-25
- Product
- Benzenamine,2-ethyl-5-nitro- 20191-74-6
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2018-08-13