2-amino-5-methylbenzenesulfonamide
- Product Name
- 2-amino-5-methylbenzenesulfonamide
- CAS No.
- 609-55-2
- Chemical Name
- 2-amino-5-methylbenzenesulfonamide
- Synonyms
- NSC57677;Pazopanib Impurity 60;2-amino-5-methylbenzenesulfomide;2-amino-5-methylbenzenesulfonamide;2-amino-4-methylbenzenesulfonamide;2-azanyl-5-methyl-benzenesulfonamide;Benzenesulfonamide, 2-amino-5-methyl-;Benzenesulfonamide, 2-amino-5-methyl- (9CI)
- CBNumber
- CB71040804
- Molecular Formula
- C7H10N2O2S
- Formula Weight
- 186.23
- MOL File
- 609-55-2.mol
2-amino-5-methylbenzenesulfonamide Property
- storage temp.
- 2-8°C
- InChI
- InChI=1S/C7H10N2O2S/c1-5-2-3-6(8)7(4-5)12(9,10)11/h2-4H,8H2,1H3,(H2,9,10,11)
- InChIKey
- GKTVIFGJASUBGA-UHFFFAOYSA-N
- SMILES
- C1(S(N)(=O)=O)=CC(C)=CC=C1N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 9112AB
- Product name
- 2-Amino-5-methylbenzenesulfonamide
- Packaging
- 500mg
- Price
- $786
- Updated
- 2021/12/16
- Product number
- 609552
- Product name
- 2-Amino-5-methylbenzenesulfonamide
- Packaging
- 500mg
- Price
- $798.7
- Updated
- 2021/12/16
- Product number
- CD12055999
- Product name
- 2-Amino-5-methylbenzenesulfonamide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $853
- Updated
- 2021/12/16
- Product number
- 609552
- Product name
- 2-Amino-5-methylbenzenesulfonamide
- Packaging
- 1g
- Price
- $1534.7
- Updated
- 2021/12/16
- Product number
- 609552
- Product name
- 2-Amino-5-methylbenzenesulfonamide
- Packaging
- 250mg
- Price
- $489.6
- Updated
- 2021/12/16
2-amino-5-methylbenzenesulfonamide Chemical Properties,Usage,Production
Uses
2-amino-5-methylbenzenesulfonamide is an important organic reagent that can be used as a building block for the synthesis of many organic compounds. It could reacted with triethyl orthoformate to give 7-Methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide by ring closure. It was an intermediate of potent AMPA receptor potentiators[1].
Synthesis
A solution of 7-methyl-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (10, 10 g, 47,12 mmol) in sulfuric acid 50% (150 mL) was refluxed until complete dissolution of the suspension. At the end of the reaction, the solution was adjusted to pH 7 with an aqueous solution of concentrated NaOH. The solvent was removed by distillation under reduced pressure. The residue was triturated with methanol and the salts were eliminated by filtration. The filtrate was concentrated to dryness under reduced pressure and the residue was triturated in water (a minimum). The resulting precipitate was collected by filtration, washed with water, and dried to afford 2-amino-5-methylbenzenesulfonamide[1].
References
[1] Dintilhac G, et al. New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. RSC Medicinal Chemistry, 2011; 2: 509-523.
2-amino-5-methylbenzenesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-amino-5-methylbenzenesulfonamide manufacturers
- Product
- 2-amino-5-methylbenzenesulfonamide 609-55-2
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2018-07-27