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2-amino-5-methylbenzenesulfonamide

Product Name
2-amino-5-methylbenzenesulfonamide
CAS No.
609-55-2
Chemical Name
2-amino-5-methylbenzenesulfonamide
Synonyms
NSC57677;Pazopanib Impurity 60;2-amino-5-methylbenzenesulfomide;2-amino-5-methylbenzenesulfonamide;2-amino-4-methylbenzenesulfonamide;2-azanyl-5-methyl-benzenesulfonamide;Benzenesulfonamide, 2-amino-5-methyl-;Benzenesulfonamide, 2-amino-5-methyl- (9CI)
CBNumber
CB71040804
Molecular Formula
C7H10N2O2S
Formula Weight
186.23
MOL File
609-55-2.mol
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2-amino-5-methylbenzenesulfonamide Property

storage temp. 
2-8°C
InChI
InChI=1S/C7H10N2O2S/c1-5-2-3-6(8)7(4-5)12(9,10)11/h2-4H,8H2,1H3,(H2,9,10,11)
InChIKey
GKTVIFGJASUBGA-UHFFFAOYSA-N
SMILES
C1(S(N)(=O)=O)=CC(C)=CC=C1N
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
9112AB
Product name
2-Amino-5-methylbenzenesulfonamide
Packaging
500mg
Price
$786
Updated
2021/12/16
Alichem
Product number
609552
Product name
2-Amino-5-methylbenzenesulfonamide
Packaging
500mg
Price
$798.7
Updated
2021/12/16
Crysdot
Product number
CD12055999
Product name
2-Amino-5-methylbenzenesulfonamide
Purity
95+%
Packaging
5g
Price
$853
Updated
2021/12/16
Alichem
Product number
609552
Product name
2-Amino-5-methylbenzenesulfonamide
Packaging
1g
Price
$1534.7
Updated
2021/12/16
Alichem
Product number
609552
Product name
2-Amino-5-methylbenzenesulfonamide
Packaging
250mg
Price
$489.6
Updated
2021/12/16
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2-amino-5-methylbenzenesulfonamide Chemical Properties,Usage,Production

Uses

2-amino-5-methylbenzenesulfonamide is an important organic reagent that can be used as a building block for the synthesis of many organic compounds. It could reacted with triethyl orthoformate to give 7-Methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide by ring closure. It was an intermediate of potent AMPA receptor potentiators[1].

Synthesis

A solution of 7-methyl-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (10, 10 g, 47,12 mmol) in sulfuric acid 50% (150 mL) was refluxed until complete dissolution of the suspension. At the end of the reaction, the solution was adjusted to pH 7 with an aqueous solution of concentrated NaOH. The solvent was removed by distillation under reduced pressure. The residue was triturated with methanol and the salts were eliminated by filtration. The filtrate was concentrated to dryness under reduced pressure and the residue was triturated in water (a minimum). The resulting precipitate was collected by filtration, washed with water, and dried to afford 2-amino-5-methylbenzenesulfonamide[1].

References

[1] Dintilhac G, et al. New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. RSC Medicinal Chemistry, 2011; 2: 509-523.

2-amino-5-methylbenzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-amino-5-methylbenzenesulfonamide Suppliers

China 32 Europe 1 Germany 1 United States 5 Global 39
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 2-amino-5-methylbenzenesulfonamide manufacturers

Career Henan Chemical Co
Product
2-amino-5-methylbenzenesulfonamide 609-55-2
Price
US $20.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2018-07-27

609-55-2, 2-amino-5-methylbenzenesulfonamideRelated Search:

5-Amino-2-methylbenzenesulfonamide 3-Methyl-6-nitroindazole 2-Ethyl-5-nitrobenzenamine ,98% N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine Pazopanib Impurity 48 3-methyl-1H-indazol-6-amine 5-Amino-2,3-dimethyl-2H-indazole Pazopanib Impurity 32 2,4-Dichloropyrimidine Benzenamine, 2-ethyl-4-nitro- Pazopanib-d6 2H-Indazol-4-amine, 2,3-dimethyl- 1H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-3-methyl- 6-Nitroindazole 3-AMINO-4-METHYLBENZENESULFONAMIDE Pazopanib Impurity 47 alpiropride 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide

  • 2-amino-5-methylbenzenesulfonamide
  • Benzenesulfonamide, 2-amino-5-methyl- (9CI)
  • NSC57677
  • Benzenesulfonamide, 2-amino-5-methyl-
  • 2-azanyl-5-methyl-benzenesulfonamide
  • 2-amino-4-methylbenzenesulfonamide
  • 2-amino-5-methylbenzenesulfomide
  • Pazopanib Impurity 60
  • 609-55-2
  • SULFONAMIDE