PF03716556

Product Name: PF03716556
CAS No.: 928774-43-0
Chemical Name: PF03716556
Synonyms: CS-1022;PF 3716556;PF03716556;PF03716556 USP/EP/BP;PF-3716556 PF3716556;PF-03716556; PF03716556;PF3716556/PF-3716556/PF-03716556;PF-3716556;PF-03716556; PF03716556;(R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-ca;(R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide
CBNumber: CB02526164
Molecular Formula: C22H26N4O3
Formula Weight: 394.47
MOL File: 928774-43-0.mol

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PF03716556 Property

Melting point:: 143-145°C
Density: 1.30
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO: ≥10mg/mL
form: powder
pka: 14.18±0.10(Predicted)
color: white to tan

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0155
Product name: PF-03716556
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0155
Product name: PF-03716556
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $545
Updated: 2023/06/20

Cayman Chemical

Product number: 17710
Product name: PF-3716556
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 17710
Product name: PF-3716556
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 17710
Product name: PF-3716556
Purity: ≥98%
Packaging: 25mg
Price: $225
Updated: 2024/03/01

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PF03716556 Chemical Properties,Usage,Production

Chemical Properties

Light Tan Solid

Uses

A novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

Biological Activity

the gastric h+,k+-atpase, which is responsible for gastric acid secretion, is a p2-type atpase located in the apical membrane of parietal cells. inhibition of the h+,k+-atpase is currently the most effective way to control gastric acid secretion and remains an attractive target for the medical treatment of acidrelated diseases. pf-03716556 is a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

in vitro

pf-03716556 demonstrated 3-fold greater inhibitory activity than revaprazan, the only acid pump antagonist that has been available on the market, in ion-tight assay. kinetics experiments revealed that pf-03716556 has a competitive and reversible mode of action [1].

in vivo

pf-03716556 did not display any species differences, exhibiting highly selective profile including the canine kidney h+,k+-atpase. in addition, more rapid onset of action than omeprazole and 3-fold greater potency than revaprazan were observed in ghosh-schild rats and heidenhain pouch dogs [2].

IC 50

in porcine ion-tight membrane vesicles, pf-03716556 inhibited h+,k+-atpase activity in a concentration-dependent manner, with a pic50 value of 7.095 ± 0.077 at ph 7.4.

storage

-20°C

References

[1] mori h, tonai-kachi h, ochi y, taniguchi y, ohshiro h, takahashi n, aihara t, hirao a, kato t, sakakibara m, kurebayashi y. n-(2-hydroxyethyl)-n,2-dimethyl-8-{[(4r)-5-methyl-3,4- dihydro-2h-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (pf-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. j pharmacol exp ther. 2009;328(2):671-9.

PF03716556 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF03716556 Suppliers

Canada 1 China 61 India 2 United Kingdom 2 United States 15 Global 81

Shanghai Boyle Chemical Co., Ltd.

Tel
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
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China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
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NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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EnliPharma Technology Co., Ltd

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AdooQ BioScience, LLC

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Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
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CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
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928774-43-0, PF03716556Related Search:

G-STROPHANTHIN

8-[[(4R)-3,4-Dihydro-5-Methyl-2H-1-benzopyran-4-yl]aMino]-N-(2-hydroxyethyl)-N,2-diMethyliMidazo[1,2-a]pyridine-6-carboxaMide

N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa

(R)-N-(2-hydroxyethyl)-N,2-dimethyl-8-(5-methyl-3,4-dihydro-2H-chromen-4-ylamino)H-imidazo[1,2-a]pyridine-6-carboxamide

8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethylimidazo[1,2-a]pyridine-6-carboxamide PF 03716556

[N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide]

PF03716556

PF 3716556

PF-3716556;PF-03716556; PF03716556

(R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-ca

PF3716556/PF-3716556/PF-03716556

PF-03716556; PF03716556

CS-1022

Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(4R)-3,4-dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-

PF03716556 USP/EP/BP

(R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide

PF-3716556 PF3716556

928774-43-0

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