ChemicalBook > CAS DataBase List > 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester
- Product Name
- 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester
- CAS No.
- 170908-81-3
- Chemical Name
- 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester
- Synonyms
- DOTA-NHS-ester;DOTA mono-NHS ester;DOTA-NHS-ester(B-280);DOTA-NHS-ester, 10 mM in DMSO;Tetraxetan N-hydroxysuccinimide;DOTA mono-N-hydroxysuccinimide ester;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-2-pyrrolidinyl) ester;1, 4, 7, 10-Tetraazacyclododecana-1, 4, 7-tris-tert-butyl acetate-10-N-a-Fmoc-N-e-acetamido-L-lysine);1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid,10-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-
- CBNumber
- CB02548816
- Molecular Formula
- C20H31N5O10
- Formula Weight
- 501.49
- MOL File
- 170908-81-3.mol
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1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester Property
- Boiling point:
- 743.7±70.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, sealed storage, away from moisture
- solubility
- DMSO: 50 mg/mL (99.70 mM)
- pka
- 2.46±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Appearance
- white powder
- InChI
- InChI=1S/C20H31N5O10/c26-15-1-2-16(27)25(15)35-20(34)14-24-9-7-22(12-18(30)31)5-3-21(11-17(28)29)4-6-23(8-10-24)13-19(32)33/h1-14H2,(H,28,29)(H,30,31)(H,32,33)
- InChIKey
- XSVWFLQICKPQAA-UHFFFAOYSA-N
- SMILES
- N1(CC(ON2C(=O)CCC2=O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1
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N-Bromosuccinimide Price
TRC
- Product number
- D494865
- Product name
- DOTA-NHS-ester
- Packaging
- 10mg
- Price
- $70
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0101897
- Product name
- DOTA-NHS-ester
- Packaging
- 100mg
- Price
- $800
- Updated
- 2021/12/16
Chemenu
- Product number
- CM198855
- Product name
- 2,2'',2''''-(10-(2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triaceticacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $1290
- Updated
- 2021/12/16
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1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester Chemical Properties,Usage,Production
Description
DOTA (dodecane tetraacetic acid, also known as tetraxetan) is a complexing agent, especially for lanthanide ions. DOTA-NHS ester is a bifunctional linker containing chelating and N-hydroxysuccinimide (NHS) ester groups for conjugation with amine-containing biomolecules.
DOTA-NHS ester can be used to label radiotherapeutic agents or imaging probes and detect labeled tumors with PET, SPECT, and CT methods.
Uses
DOTA-NHS-ester is a bifunctional chelator.
in vivo
In a microPET images of a mouse bearing SKOV3 tumor, 64Cu-DOTA-HSA-ZHER2:342 is injected to the mouse tail. microPET images of a mouse bearing SKOV3 tumor at 1, 4, 24 and 48 h after tail vein injection.The SKOV3 tumor is visible with a low tumor-to-background contrast at 1 h post-injection (p.i.), but with a very good tumor-to-background contrast at 4 and 24 h p.i.Quantification analysis reveals that the SKOV3 tumor uptake values increases with time and are found to be 5.63%, 9.98%, 14.34% and 14.12% ID/g at 1, 4, 24, and 48 h, respectively[1].
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester 170908-81-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
Xian confluore Biological Technology Co., Ltd.
- Product
- DOTA mono-NHS ester 170908-81-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >95.00%
- Supply Ability
- 1g
- Release date
- 2024-04-01