Azetidine
- Product Name
- Azetidine
- CAS No.
- 503-29-7
- Chemical Name
- Azetidine
- Synonyms
- Aztidine;AZETIDINE;AZETIDINE 99%;Azetidine,98%;Azacyclobutane;Azetidine ,95%;tetrahydroazete;Trimethylenimine;1,3-Propylenimine;Azete, tetrahydro-
- CBNumber
- CB5215197
- Molecular Formula
- C3H7N
- Formula Weight
- 57.09
- MOL File
- 503-29-7.mol
Azetidine Property
- Melting point:
- -70°C
- Boiling point:
- 61-62 °C(lit.)
- Density
- 0.847 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.432(lit.)
- Flash point:
- −5 °F
- storage temp.
- Store below +30°C.
- pka
- 11.29(at 25℃)
- form
- Liquid
- color
- Clear colorless
- Water Solubility
- miscible
- Sensitive
- Moisture Sensitive/Air Sensitive
- BRN
- 102384
- InChI
- 1S/C3H7N/c1-2-4-3-1/h4H,1-3H2
- InChIKey
- HONIICLYMWZJFZ-UHFFFAOYSA-N
- SMILES
- C1CNC1
- CAS DataBase Reference
- 503-29-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Azetidine(503-29-7)
- EPA Substance Registry System
- Azetidine (503-29-7)
Safety
- Hazard Codes
- F,C
- Risk Statements
- 11-34
- Safety Statements
- 16-26-36/37/39-45
- RIDADR
- UN 2733 3/PG 2
- WGK Germany
- 3
- F
- 2-10
- TSCA
- TSCA listed
- HazardClass
- 3.1
- PackingGroup
- I
- HS Code
- 29339990
- Storage Class
- 3 - Flammable liquids
- Hazard Classifications
- Eye Dam. 1
Flam. Liq. 2
Skin Corr. 1B
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 281069
- Product name
- Azetidine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $61.6
- Updated
- 2025/07/31
- Product number
- 281069
- Product name
- Azetidine
- Purity
- 98%
- Packaging
- 1g
- Price
- $235
- Updated
- 2025/07/31
- Product number
- A3257
- Product name
- Azetidine
- Packaging
- 1G
- Price
- $140
- Updated
- 2025/07/31
- Product number
- A3257
- Product name
- Azetidine
- Packaging
- 5G
- Price
- $482
- Updated
- 2025/07/31
- Product number
- FA34786
- Product name
- Azetidine
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
Azetidine Chemical Properties,Usage,Production
Chemical Properties
clear colorless liquid
Uses
suzuki reaction
Uses
Azetidine is involved in a high yielding palladium-catalyzed cross-coupling reaction with aryl bromides. Further, it is used in Ullmann type coupling reaction with iodonitroflourenes. In addition to this, it reacts with bis-(3-amino-propyl)-amine to prepare N,N'-bis-(3-amino-propyl)-propanediyldiamine using palladium as a catalyst.
Definition
ChEBI: Azetidine is a saturated organic heteromonocyclic parent, a member of azetidines and an azacycloalkane.
General Description
Phototransformations of azetidine radical cations in freonic matrices under the action of light with λ = 436nm has been investigated. The IR spectrum of azetidine in solid argon matrices has been measured.
Synthesis
To a 1-liter conical flask was added 4.0 mol of azetidine hydrochloride and 280 g of water, and the mixture was stirred at 20 degrees Celsius until the solid was dissolved, then to a 2-liter four-necked round-bottomed flask was added 230 g of water to which was added with stirring 459.4 g ( 6.96 mol ) of potassium hydroxide, and at the end of the exothermic addition of KOH, the solution was heated to 95 degrees Celsius and maintained at 95 degrees Celsius, an aqueous solution of azetidine hydrochloride ( 11 ) was added to the hot KOH /aqueous solution, controlling the rate of addition, and completing the addition within 3 hours. After completion of the reaction, the target product, heteroazetidine, is obtained by slowly distilling and purifying the target compound.
Purification Methods
Azetidine is a flammable, hygroscopic liquid smelling of ammonia, which absorbs CO2 from air and should be kept under Argon. Purify it by drying it over solid KOH and distilling it through a short Vigreux column (p 11) at atmospheric pressure (under Argon) and keeping the pot temperature below 210o. It is moisture sensitive. The hydrochloride M 93.6 has m > 300o and the hydroiodide has m 146.5o(from EtOH). The N-Me derivative has m 112o(from *C6H6/pet ether), and the Nphenylcarbamoyl derivative has m 189-190o(from EtOH). [Searles et al. J Am Chem Soc 7 8 4917 1956, Beilstein 20 H 2, 20 I 3, 20 II 3, 20 III/IV 53, 20/1 V 136.]
Azetidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azetidine manufacturers
- Product
- Azetidine 503-29-7
- Price
- US $1000.00-800.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-16
- Product
- Azetidine 503-29-7
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- Azetidine 503-29-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.2%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18