ChemicalBook > CAS DataBase List > Cephaloridine

Cephaloridine

Product Name
Cephaloridine
CAS No.
50-59-9
Chemical Name
Cephaloridine
Synonyms
Sefacin;Ceporin;Ceporan;Ceflorin;Keflodin;Keflordin;Cephaloridine;Cephaloridine II;Cephaloridine USP/EP/BP;CEFALORIDINE (ALPHA FORM) USP/EP/BP
CBNumber
CB4875354
Molecular Formula
C19H17N3O4S2
Formula Weight
0
MOL File
50-59-9.mol
More
Less

Cephaloridine Property

Melting point:
184°C
alpha 
D +47.7° (c = 1.25 in water)
Density 
1.3230 (rough estimate)
refractive index 
1.6390 (estimate)
storage temp. 
2-8°C
pka
3.2(at 25℃)
Water Solubility 
>20g/L(21 ºC)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
22-36/37-45
Toxicity
LD50 mice, rats (g/kg): >15, 2.5-4 orally; in monkeys (g/kg): >0.2 i.m. (Atkinson)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

Cephaloridine Chemical Properties,Usage,Production

Originator

Ceporin,Glaxo,UK,1964

Uses

Antibacterial agent.

Definition

ChEBI: A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.

Manufacturing Process

7-Aminocephalosporanic acid (5.00 g) which passed through a 100-mesh sieve was suspended in boiling ethyl acetate (200 ml), and 2-thienylacetyl chloride (Cagniant, Bull. Soc. Chim. France, 1949, 847) (4.42 g, 1.5 equiv.) was added in ethyl acetate (20 ml). The mixture was boiled under reflux for 40 minutes, cooled, and filtered. Aniline (5.03 ml) was added, and after 1 hour the mixture was extracted with 3% sodium hydrogen carbonate solution (1 x 150 ml, 2 x 100 ml, 1 x 50 ml) and the alkaline extracts washed with ethyl acetate (3 x 100 ml). The aqueous solution was acidified to pH 1.2, and extracted with ethyl acetate (2 x 150 ml). The ethyl acetate extract was washed with water (4 x 40 ml), dried (MgSO4), and concentrated in vacuo to low volume. The crude 7-2'-thienylacetamidocephalosporanic acid (2.5 g) which separated was collected by filtration. Evaporation of the filtrate gave a further 2.68 g (71%) of the product, which was purified by crystallization from ethyl acetate, then aqueous acetone, MP 150°C to 157°C (decomp.).
7-2'-Thienylacetamidocephalosporanic acid (7.0 g) was suspended in water (60 ml) and stirred with pyridine (7 ml) until the acid dissolved. The resulting solution (pH 5.9) was kept at 35°C for 3 days, then filtered and extracted with methylene chloride (4 x 60 ml). The methylene chloride extract was back-extracted with a little water and the total aqueous solutions were then percolated through a column of Dowex 1 x 8 resin, (100 to 200 mesh, 150 g) in the acetate form at pH 4.3. The column was washed with water until the optical rotation of the eluate fell to zero and the eluate (500 ml) was freeze-dried. The residual white solid was dissolved in the minimum volume of methanol and after a few minutes the pyridine derivative crystallized; this is the cephaloridine product.

brand name

Kefloridin (Lilly); Loridine (Lilly);Cepalorin;Faredina;Latorex;Lauridin.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Cefaloridine, a semi-synthetic cephalosporin antibiotic, was introduced into medicine in 1964 for the treatment of bacterial infections. It is considered to be the most toxic of the cephalosporins, and for this reason is now seldom used. Nevertheless, it still remains available in certain countries and the World Health Organization is not aware of restrictive actions taken elsewhere.

Hazard

Moderately to very toxic.

Cephaloridine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Cephaloridine Suppliers

Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9914
Advantage
58
Kuer Chemical Technology (Beijing) Co., Ltd.
Tel
4008369963
Email
kuer@kuerhuaxue.com
Country
China
ProdList
2935
Advantage
55
Aikon International Limited
Tel
025-58851090-
Fax
(6)02557626880
Email
lwan@aikonchem.com
Country
China
ProdList
13917
Advantage
58
Hefei Bomei Biotechnology Co., Ltd.
Email
531626407@qq.com
Country
CHINA
ProdList
3005
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-571-88938639
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
CHINA
ProdList
52932
Advantage
58
Dideu Industries Group Limited
Tel
029-88380327, 17691182729
Email
service@dideu.com
Country
CHINA
ProdList
29997
Advantage
58
BOC Sciences
Tel
16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19673
Advantage
58
AFINE CHEMICALS LIMITED
Tel
008657185134551
Fax
008657185134895
Email
info@afinechem.com
Country
CHINA
ProdList
15578
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-89586680
Fax
+86-29-88380327
Email
1005@dideu.com
Country
CHINA
ProdList
9937
Advantage
58
More
Less

View Lastest Price from Cephaloridine manufacturers

Dideu Industries Group Limited
Product
CEFALORIDINE (ALPHA FORM) USP/EP/BP
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01

50-59-9, CephaloridineRelated Search:


  • Cephaloridine
  • Ceflorin
  • Ceporan
  • N-[7-[2'-Thienyl-acetamidoceph-3-ylmethyl]] pyridinium-4-carboxylate
  • pyridinium, 1-((2-carboxy-8-oxo-7-(2-(2-thienyl)acetamido)-5-thia-1-azabicyclo( 4.2.0)o ct- 2-en-3-yl)methyl)-, hydroxide, inner salt 1-[(7'-beta-[2-(2-thienyl)acetamido]-8'-oxo-1'-aza-5'-t hiabicyclo[4.2.0]-oct-2 '-en-3'-yl)methyl]pyridinium-2'-carboxylate 40602 7-((2-thienyl)acetamido)-3-(1-pyridylmethyl)cephalosporanic acid 7-(alpha-(2-thienyl)acetamido)-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid 7-(alpha-(2-thienyl)acetamido)-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid b etaine
  • (6R,7R)-8-oxo-3-(pyridin-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • Ceporin
  • Keflodin
  • Keflordin
  • Sefacin
  • (6R,7R)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • Cephaloridine II
  • (6R,7R)-8-Oxo-3-(1-pyridiniumylmethyl)-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • PyridiniuM,1-[[(6R,7R)-2-carboxy-8-oxo-7-[[2-(2-thienyl)acetyl]aMino]-5-thia-1-azabicyclo[4.2.0]oct-
  • N-(7-[2′-Thienylacetamidoceph-3-ylmethyl])pyridinium 2-carboxylate
  • Cephaloridine USP/EP/BP
  • CEFALORIDINE (ALPHA FORM) USP/EP/BP
  • 50-59-9
  • C19H17N3O4S4
  • C19H17N3O4S2
  • C19H18N3O4S2