(S)-(+)-Epichlorohydrin

Product Name: (S)-(+)-Epichlorohydrin
CAS No.: 67843-74-7
Chemical Name: (S)-(+)-Epichlorohydrin
Synonyms: 2-(Chloromethyl)oxirane;EPICHLOROHYDRINE;EPICHLORHYDRIN;(S)-EPICHLOROHYDRIN;ALPHA-EPICHLOROHYDRIN;AKOS BBS-00004288;D-epichlorohydrin;(S)-Epichlorhydrin;CHLOROMETHYLOXIRANE;(+)-Epichlorohydrin
CBNumber: CB7854110
Molecular Formula: C3H5ClO
Formula Weight: 92.52
MOL File: 67843-74-7.mol

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(S)-(+)-Epichlorohydrin Property

Melting point:: −57 °C(lit.)
Boiling point:: 92-93 °C360 mm Hg(lit.)
alpha: 34 º (589nm, c=1, MeOH)
Density: 1.183 g/mL at 25 °C(lit.)
vapor density: 3.2 (vs air)
vapor pressure: 13.8 mm Hg ( 21.1 °C)
refractive index: n20/D 1.438(lit.)
Flash point:: 93 °F
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform, Methanol (Slightly)
form: Liquid
color: Clear colorless to very pale yellow
explosive limit: 21%
optical activity: [α]20/D +35°, c = 1 in methanol
Water Solubility: insoluble
BRN: 1420784
Dielectric constant: 22.9（20℃）
CAS DataBase Reference: 67843-74-7(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 45-10-23/24/25-34-43
Safety Statements: 53-45
RIDADR: UN 2023 6.1/PG 2
WGK Germany: 3
RTECS: TX4900000
Autoignition Temperature: 1421 °F
HazardClass: 6.1
PackingGroup: II
HS Code: 29038900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H350May cause cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 540080
Product name: (S)-(+)-Epichlorohydrin
Purity: 98%
Packaging: 5g
Price: $29.62
Updated: 2025/07/31

Sigma-Aldrich

Product number: 540080
Product name: (S)-(+)-Epichlorohydrin
Purity: 98%
Packaging: 25g
Price: $140.76
Updated: 2025/07/31

TCI Chemical

Product number: E0533
Product name: (S)-Epichlorohydrin
Purity: >98.0%(GC)
Packaging: 5g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: E0533
Product name: (S)-Epichlorohydrin
Purity: >98.0%(GC)
Packaging: 25g
Price: $52
Updated: 2025/07/31

TRC

Product number: E582310
Product name: (S)-Epichlorohydrin
Packaging: 100g
Price: $480
Updated: 2021/12/16

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(S)-(+)-Epichlorohydrin Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Chemical Properties

Epichlorhydrin is a colourless liquid with odour, b.p. 115°C.

Uses

(S)-(+)-Epichlorohydrin is utilized for the synthesis of macquarimicins and hydroxyisoxazolidines and (+)-cis-sylvaticin, which is a potential antitumor agent. It is used to synthesize inhibitors of fatty acid oxidation as potential metabolic modulators. It acts as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels, lacquers and cement for celluloid. It is also used as a stabilizer and also useful as a bifunctional alkylating agent with the potential to form DNA cross-links.

Uses

S-enantiomer of Epichlorohydrin, (S)-Epichlorohydrin), an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.

Definition

ChEBI: (S)-epichlorohydrin is an epichlorohydrin. It is functionally related to a (R)-1,2-epoxypropane. It is an enantiomer of a (R)-epichlorohydrin.

Synthesis

106-89-8

67843-74-7

The general procedure for the synthesis of (S)-(+)-epichlorohydrin from 1-chloro-2,3-epoxypropane is as follows: first, 463 kg of racemic epichlorohydrin was mixed with 19.2 kg of the catalyst [(1-RR)-(dibenzoyl-LLA)] made from Example 1 of the Preparation and the mixture was cooled to 5 °C. Subsequently, 49.5 kg of water was slowly added and the reaction continued at 20°C for 7 hours. Upon completion of the reaction, the reaction mixture was subjected to reduced-pressure thin-film evaporation at less than 30 °C to afford 190 kg of (S)-epichlorohydrin with an optical purity of 99.8% ee and a yield of 82%. The above reaction process was repeated by adding new racemic epichlorohydrin and water to the evaporated residue to again obtain (S)-epichlorohydrin with an optical purity of more than 99.0%ee.

References

[1] Patent: WO2008/153280, 2008, A1. Location in patent: Page/Page column 41
[2] Patent: WO2008/153280, 2008, A1. Location in patent: Page/Page column 28
[3] Tetrahedron Asymmetry, 2003, vol. 14, # 22, p. 3633 - 3638
[4] Journal of the American Chemical Society, 1995, vol. 117, # 21, p. 5897 - 5898
[5] Journal of the American Chemical Society, 1999, vol. 121, # 17, p. 4147 - 4154

(S)-(+)-Epichlorohydrin Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-Epichlorohydrin Suppliers

Americas 1 Belgium 4 Canada 2 China 414 Europe 5 France 2 Germany 9 India 27 Japan 7 Norway 1 South Korea 5 Spain 1 Switzerland 3 Ukraine 1 United Kingdom 20 United States 62 Global 564

Sichuan Hainuowei Technology Co. Ltd.

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Changzhou Huaren Chemical Co., Ltd

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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View Lastest Price from (S)-(+)-Epichlorohydrin manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-(+)-Epichlorohydrin 67843-74-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-22

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-(+)-Epichlorohydrin 67843-74-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-31

Hebei Yanxi Chemical Co., Ltd.

Product: (S)-(+)-Epichlorohydrin 67843-74-7
Price: US $25.00-10.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-11-02

67843-74-7, (S)-(+)-EpichlorohydrinRelated Search:

Propylene oxide Resin epoxy ETHYLENE OXIDE Epichlorohydrin (1S)-(+)-Camphor-10-sulphonic acid (S)-(-)-1-PHENYLETHANOL Quinic acid D(+)-10-Camphorsulfonyl chloride (S)-(+)-2-Chlorophenylglycine methyl ester (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine N-HEXYLAMINE HYDROCHLORIDE PROPYLCYCLOHEXANE N-TETRATRIACONTANE N-HENEICOSANE Azetidine Difluorochloromethane Chloromethyl methyl ether Z-3-Chloro-1-(2-chlorophenyl)-2-(4-fluorophenyl)-oxirane

(S)-(+)-2-(Chloromethyl)oxirane (S)-Epichlorohydrin (S) 1-Chloro-2,3-epoxypropane (S)-3-Chloropropylene Oxide (S)-Chloromethyloxirane (S)-(+)-1-Chloro-2,3-epoxypropane 2-(Chloromethyl)oxirane

(S)-(+)-CHLOROMETHYLOXIRANE

(S)-CHLOROMETHYLOXIRANE

(S)-3-CHLOROPROPYLENE OXIDE

S(+)-2-(CHLOROMETHYL)OXIRANE

(S)-(+)-1-CHLORO-2,3-EPOXYPROPANE

(S)-1-CHLORO-2,3-EPOXYPROPANE

OXIRANE, (CHLOROMETHYL)-, (2S)-

(S) Epichlorohydin or (S)1-chloro-2,3-epoxypropane

(2S)-1,2-Epoxy-3-chloropropane

S-(+)-Epichlorohydrine

(S)-(+)-EPICHLOROHYDRIN 98%

(S)-(+)-alpha-Epichlorohydrine

(S)-(+)-Epichlorohydrin,98+%

(2S)-2-(Chloromethyl)oxirane

(S)-(+)-Epichlorohydrin 67843-74-7

(S)-epichlorohydrin 67843-74-7 (S)-(+)-Epichlorohydrin

Levocarnitine Impurity 9

(S)-(+)-Epichlorhydrin, (2S)-(+)-2-(Chloromethyl)oxirane

(2S)-(ChloroMethyl)oxirane

(2S)-Epichlorohydrine

(S)-Epichlorhydrin

2(S)-Epichlorohydrin

(S)-Chloromethyloxirane (S)-3-Chloropropylene Oxide (S)-1-Chloro-2,3-epoxypropane

(S)-(+)-Epichlorohydrin, 98% 1GR

Oxirane,2-(chloroMethyl)-, (2S)-

2-(Chloromethyl)oxirane

(S)-(+)-Epichlorohyd

(2S)-(+)-3-Chloro-1,2-propenoxide

G-CHLOROPROPYLENE OXIDE

EPICHLORHYDRIN

EPICHLOROHYDRINE

CHLOROMETHYLOXIRANE

2,3-EPOXYPROPYL CHLORIDE

AKOS BBS-00004288

ALPHA-EPICHLOROHYDRIN

3-CHLOROPROPYLENE OXIDE

(S)-(+)-EPICHLOROHYDRIN

(S)-EPICHLOROHYDRIN

(S)-Epichlorohydrin&gt

irane,2-(chloromethyl)-, (2S)-

(S)-(+)-Epichlorohydrin ISO 9001：2015 REACH

Oxyclozanide 2277-92-1

(+)-Epichlorohydrin

D-epichlorohydrin

Disodium phosphate levononidazole ester impurity B

Levaroxaban Impurity 13

Phosphoric acid levononidazole ester disodium impurity B

(<i>S</i>)-(+)-Epichlorohydrin

(S)-(+)-Epichlorohydrin, 99%

(S)-Epichlorohydrin(ECH), 99.5%min

67843-74-7

Oxygen Compounds

Volatiles/ Semivolatiles

Chromatography

Environmental Standards

Epoxides

Organic Building Blocks