ChemicalBook > CAS DataBase List > (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Product Name
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
CAS No.
300543-56-0
Chemical Name
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
Synonyms
Levocetirizine Impurity A;Levocetirizine Impurity 2;(R)-Cetirizine EP Impurity A;(R)-1-[(4-Chlorophenyl)phenylmethyl;(R)-1-(p-Chlorobenzhydryl)piperazine;Chlorobenzhydryl Piperazine (F02160);(R)-N-(4-Chlorobenzyl hydryl) piperazine;R(-)-1-[(4-Chlorophenyl)benzyl]piperazine;(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE;(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine
CBNumber
CB2299774
Molecular Formula
C17H19ClN2
Formula Weight
286.8
MOL File
300543-56-0.mol
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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Property

Melting point:
91-93oC
Boiling point:
409.1±0.0 °C(Predicted)
Density 
1.158
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
pka
8.99±0.10(Predicted)
form 
Solid
color 
White
PH
9.38 at 25℃ and 10.07g/L
Water Solubility 
Soluble in chloroform, methanol, and dichloromethane. Slightly soluble in water.
InChI
InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/t17-/s3
InChIKey
UZKBSZSTDQSMDR-SCBJWRGWNA-N
SMILES
[C@@H](N1CCNCC1)(C1C=CC=CC=1)C1C=CC(Cl)=CC=1 |&1:0,r|
CAS DataBase Reference
300543-56-0
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Safety

HS Code 
2933599550
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H63722
Product name
(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
Packaging
5g
Price
$424.65
Updated
2024/03/01
Alfa Aesar
Product number
H63722
Product name
(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
Packaging
1g
Price
$99.9
Updated
2023/06/20
Alfa Aesar
Product number
H63722
Product name
(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
Packaging
250mg
Price
$33.2
Updated
2023/06/20
TRC
Product number
C379574
Product name
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
Packaging
25mg
Price
$120
Updated
2021/12/16
Matrix Scientific
Product number
089223
Product name
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
Packaging
25g
Price
$168
Updated
2021/12/16
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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Chemical Properties,Usage,Production

Uses

Intermediate in the production of (R)-Cetirizine (C281106).

Uses

(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine intermediate in the production of (R)-Cetirizine.

Application

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine could be used to synthesize a series of novel derivatives. Most of these derivatives significantly affected both allergic asthma and allergic itching. Meanwhile, in the test of allergic itching, five of the 19 compounds have more potent activities than levocetirizine[1].

References

[1] Lisheng Wang. “Design, synthesis, and anti-allergic activities of novel (R)(-)-1-[(4-chlorophenyl)phenyl methyl]piperazine derivatives.” Medicinal Chemistry Research 21 1 (2010): 124–132.

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Suppliers

Chongqing Ensky Pharmaceutical Co.,Ltd.
Tel
023-86815286 13983794297
Fax
+86-23-86815116
Email
sales@ensky-chemical.com
Country
China
ProdList
90
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58
Enki Biopharmaceuticals(Shanghai) Limited
Tel
021-57680965 13916707528
Fax
(21) 5768 0922
Email
yusu@enkibiopharma.com
Country
China
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45
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55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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84
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
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China
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18207
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JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
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Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
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China
ProdList
14103
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
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32321
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50
Shanghai Sphchem Co., Ltd.
Tel
21-21-56491756 13512199871
Fax
021-5649-1756
Email
sales@panhongchem.com
Country
China
ProdList
3999
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55
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View Lastest Price from (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine manufacturers

Career Henan Chemica Co
Product
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0
Price
US $1.00/g
Min. Order
1g
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-10-28
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Cetirizine Impurity 35 300543-56-0
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-26
Henan Aochuang Chemical Co.,Ltd.
Product
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19

300543-56-0, (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazineRelated Search:


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  • Levocetirizine Impurity 2
  • (R)-(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
  • (R)-1-(p-Chlorobenzhydryl)piperazine
  • Piperazine,1-[(R)-(4-chlorophenyl)phenylMethyl]-
  • (R)-1-[^a-(4-Chlorophenyl)benzyl]piperazine, 97%
  • (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine
  • Levocetirizine Impurity A
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  • (R)-Cetirizine EP Impurity A
  • (R)-1-[(4-Chlorophenyl)phenylmethyl
  • (R)-Cetirizine EP Impurity A (Levocetirizine Impurity 2)
  • Levocetirizine Chlorobenzhydryl Piperazine (USP)
  • (R)-1-[^a-(4-Chlorophenyl)benzyl]piperazine,97%
  • (R)-(-)-1-[(4-chlorophenyl)phenmethyl]piperazine
  • (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine (Cetirizine Impurity)
  • Chlorobenzhydryl Piperazine (F02160)
  • TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE
  • R(-)-1-[(4-Chlorophenyl)benzyl]piperazine
  • Levocetirizine Impurity 1 (Chlorobenzhydryl piperazine)
  • (-)-1-[( 4-ChIorophenyI)PhenyImethyI] Piperazine
  • (R)-Cetirizine EP Impurity A ((R)-Hydroxyzine USP Related Compound A)
  • (R)-N-(4-Chlorobenzyl hydryl) piperazine
  • (R)-1-[(4-chlorophenyl)phenyl methyl] Piperazine (Intermediate of Levocetirizine )
  • (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine (-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
  • 300543-56-0
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