ChemicalBook > CAS DataBase List > (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
- Product Name
- (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
- CAS No.
- 300543-56-0
- Chemical Name
- (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
- Synonyms
- Levocetirizine Impurity A;Levocetirizine Impurity 2;(R)-Cetirizine EP Impurity A;(R)-1-[(4-Chlorophenyl)phenylmethyl;(R)-1-(p-Chlorobenzhydryl)piperazine;Chlorobenzhydryl Piperazine (F02160);(R)-N-(4-Chlorobenzyl hydryl) piperazine;R(-)-1-[(4-Chlorophenyl)benzyl]piperazine;(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE;(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine
- CBNumber
- CB2299774
- Molecular Formula
- C17H19ClN2
- Formula Weight
- 286.8
- MOL File
- 300543-56-0.mol
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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Property
- Melting point:
- 91-93oC
- Boiling point:
- 409.1±0.0 °C(Predicted)
- Density
- 1.158
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
- pka
- 8.99±0.10(Predicted)
- form
- Solid
- color
- White
- PH
- 9.38 at 25℃ and 10.07g/L
- Water Solubility
- Soluble in chloroform, methanol, and dichloromethane. Slightly soluble in water.
- InChI
- InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/t17-/s3
- InChIKey
- UZKBSZSTDQSMDR-SCBJWRGWNA-N
- SMILES
- [C@@H](N1CCNCC1)(C1C=CC=CC=1)C1C=CC(Cl)=CC=1 |&1:0,r|
- CAS DataBase Reference
- 300543-56-0
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Safety
- HS Code
- 2933599550
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Alfa Aesar
- Product number
- H63722
- Product name
- (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
- Packaging
- 5g
- Price
- $424.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H63722
- Product name
- (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
- Packaging
- 1g
- Price
- $99.9
- Updated
- 2023/06/20
Alfa Aesar
- Product number
- H63722
- Product name
- (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
- Packaging
- 250mg
- Price
- $33.2
- Updated
- 2023/06/20
TRC
- Product number
- C379574
- Product name
- (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
- Packaging
- 25mg
- Price
- $120
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 089223
- Product name
- (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
- Packaging
- 25g
- Price
- $168
- Updated
- 2021/12/16
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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Chemical Properties,Usage,Production
Uses
Intermediate in the production of (R)-Cetirizine (C281106).
Uses
(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine intermediate in the production of (R)-Cetirizine.
Application
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine could be used to synthesize a series of novel derivatives. Most of these derivatives significantly affected both allergic asthma and allergic itching. Meanwhile, in the test of allergic itching, five of the 19 compounds have more potent activities than levocetirizine[1].
References
[1] Lisheng Wang. “Design, synthesis, and anti-allergic activities of novel (R)(-)-1-[(4-chlorophenyl)phenyl methyl]piperazine derivatives.” Medicinal Chemistry Research 21 1 (2010): 124–132.
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Suppliers
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View Lastest Price from (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine manufacturers
ShenZhen H&D Pharmaceutical Technology Co., LTD
- Product
- Cetirizine Impurity 35 300543-56-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-04-26
Henan Aochuang Chemical Co.,Ltd.
- Product
- (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
Career Henan Chemica Co
- Product
- (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20tons
- Release date
- 2020-10-28
300543-56-0, (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazineRelated Search:
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