ChemicalBook > CAS DataBase List > (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Product Name
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
CAS No.
300543-56-0
Chemical Name
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
Synonyms
Levocetirizine Impurity A;Levocetirizine Impurity 2;(R)-Cetirizine EP Impurity A;(R)-1-[(4-Chlorophenyl)phenylmethyl;(R)-1-(p-Chlorobenzhydryl)piperazine;Chlorobenzhydryl Piperazine (F02160);(R)-N-(4-Chlorobenzyl hydryl) piperazine;R(-)-1-[(4-Chlorophenyl)benzyl]piperazine;(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE;(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine
CBNumber
CB2299774
Molecular Formula
C17H19ClN2
Formula Weight
286.8
MOL File
300543-56-0.mol
More
Less

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Property

Melting point:
91-93oC
Boiling point:
409.1±0.0 °C(Predicted)
Density 
1.158
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
pka
8.99±0.10(Predicted)
form 
Solid
color 
White
PH
9.38 at 25℃ and 10.07g/L
Water Solubility 
Soluble in chloroform, methanol, and dichloromethane. Slightly soluble in water.
InChI
InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/t17-/s3
InChIKey
UZKBSZSTDQSMDR-SCBJWRGWNA-N
SMILES
[C@@H](N1CCNCC1)(C1C=CC=CC=1)C1C=CC(Cl)=CC=1 |&1:0,r|
CAS DataBase Reference
300543-56-0
More
Less

Safety

HS Code 
2933599550
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Alfa Aesar
Product number
H63722
Product name
(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
Packaging
5g
Price
$424.65
Updated
2024/03/01
Alfa Aesar
Product number
H63722
Product name
(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
Packaging
1g
Price
$99.9
Updated
2023/06/20
Alfa Aesar
Product number
H63722
Product name
(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
Packaging
250mg
Price
$33.2
Updated
2023/06/20
TRC
Product number
C379574
Product name
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
Packaging
25mg
Price
$120
Updated
2021/12/16
Matrix Scientific
Product number
089223
Product name
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
Packaging
25g
Price
$168
Updated
2021/12/16
More
Less

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Chemical Properties,Usage,Production

Uses

Intermediate in the production of (R)-Cetirizine (C281106).

Uses

(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine intermediate in the production of (R)-Cetirizine.

Application

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine could be used to synthesize a series of novel derivatives. Most of these derivatives significantly affected both allergic asthma and allergic itching. Meanwhile, in the test of allergic itching, five of the 19 compounds have more potent activities than levocetirizine[1].

References

[1] Lisheng Wang. “Design, synthesis, and anti-allergic activities of novel (R)(-)-1-[(4-chlorophenyl)phenyl methyl]piperazine derivatives.” Medicinal Chemistry Research 21 1 (2010): 124–132.

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Suppliers

Canada 2 China 114 Germany 2 India 34 The Netherlands 1 Ukraine 1 United Kingdom 4 United States 24 Global 182
Chongqing Ensky Pharmaceutical Co.,Ltd.
Tel
023-86815286 13983794297
Fax
+86-23-86815116
Email
sales@ensky-chemical.com
Country
China
ProdList
88
Advantage
58
Enki Biopharmaceuticals(Shanghai) Limited
Tel
021-57680965 13916707528
Fax
(21) 5768 0922
Email
yusu@enkibiopharma.com
Country
China
ProdList
53
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Shanghai Sphchem Co., Ltd.
Tel
21-21-56491756 13512199871
Fax
021-5649-1756
Email
sales@panhongchem.com
Country
China
ProdList
4000
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9900
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
4969
Advantage
50
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3933
Advantage
58
Shanghai Hao Yun Chemical Science Co.,Ltd.
Tel
021-68367562 15002147577;
Fax
021-68369562
Email
sales@haoyunchem.com
Country
China
ProdList
497
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17994
Advantage
56
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9911
Advantage
50
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5943
Advantage
50
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
3989
Advantage
60
Sinfachem Limited.
Tel
025-84683399 13952017251
Email
sinfachem@foxmail.com
Country
China
ProdList
308
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5881
Advantage
65
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-50664929, 13971561712
Fax
027-50664927 / QQ: 3452835437
Email
hubxys2001@163.com
Country
China
ProdList
1437
Advantage
55
Jiaozuo Star Chemical Technology Co., Ltd.
Tel
15003910607
Fax
-
Email
jzstarchem@126.com
Country
China
ProdList
84
Advantage
58
Capot Chemical Co.,Ltd.
Tel
571-85586718 +8613336195806
Fax
+86-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
29797
Advantage
60
Aikon International Limited
Tel
025-66113011 18112977050
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16028
Advantage
58
Conier Chem & Pharma Limited
Tel
13368167990
Email
sales@conier.com
Country
China
ProdList
2809
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 18521078705
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
19942
Advantage
58
Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187 13917602471
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
China
ProdList
9908
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
24971
Advantage
58
QuZhou Rainfull Chemical Co.,Ltd.
Tel
0570-3062289 13819008176 15068926975
Fax
0570-3063388
Email
527757556@qq.com
Country
China
ProdList
2959
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10305
Advantage
58
GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD
Tel
020-37651955 13682223272
Fax
020-87659730
Email
173901442@qq.com
Country
China
ProdList
695
Advantage
58
Abydos Scientific
Tel
025-84767922 18936879710
Email
sales@abydoscientific.com
Country
China
ProdList
1029
Advantage
58
yxinchem
Tel
+86-0710-4323688 +86-18071785587
Fax
15502706050
Email
market@yxinchem.com
Country
China
ProdList
1022
Advantage
58
Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.
Tel
029-87576359 17691182729
Fax
029-88380327
Email
1018@dideu.com
Country
China
ProdList
1985
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55896
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
0755-22202135 13316968096
Email
1979313431@qq.com
Country
China
ProdList
7787
Advantage
58
Hefei Molake Biotechnology Co., Ltd.
Tel
0551-66336380 18956014586
Fax
055166336380
Email
983438788@qq.com
Country
China
ProdList
2093
Advantage
58
TOSUN PHARM
Tel
020-61855200 13326451905
Email
2881290884@qq.com
Country
China
ProdList
7497
Advantage
58
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
12711
Advantage
58
Xi'an MC Biotech, Co., Ltd.
Tel
029-89275612 +8618991951683
Fax
8618991951683
Email
mcbio_sales@163.com
Country
China
ProdList
2255
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25363
Advantage
58
sgtlifesciences pvt ltd
Tel
+8617013299288
Email
dj@sgtlifesciences.com
Country
China
ProdList
12382
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
CHINA
ProdList
52867
Advantage
58
SIMAGCHEM CORP
Tel
+86-13806087780
Email
sale@simagchem.com
Country
China
ProdList
17367
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23931
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28180
Advantage
58
Shanghai Taijilin Industrial Co., Ltd.
Tel
021-021-50630626 18964684208
Fax
021-50563898
Email
kate@tajilin.com
Country
China
ProdList
1212
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22968
Advantage
58
More
Less

View Lastest Price from (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Cetirizine Impurity 35 300543-56-0
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-26
Henan Aochuang Chemical Co.,Ltd.
Product
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Career Henan Chemica Co
Product
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0
Price
US $1.00/g
Min. Order
1g
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-10-28

300543-56-0, (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazineRelated Search:

(S)-(+)-Epichlorohydrin Acetic acid, 2-[2-[2-[4-[(4- chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]ethoxy]- Levocetirizine Impurity 4 Levocetirizine amide impurity HCl 1-(o-Chloro-α-phenylbenzyl)piperazine Piperazine D-3-Bromocamphor-8-sulfonic acid ammonium salt

  • (-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE
  • Levocetirizine Impurity 2
  • (R)-(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
  • (R)-1-(p-Chlorobenzhydryl)piperazine
  • Piperazine,1-[(R)-(4-chlorophenyl)phenylMethyl]-
  • (R)-1-[^a-(4-Chlorophenyl)benzyl]piperazine, 97%
  • (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine
  • Levocetirizine Impurity A
  • (130018-88-1) (-)-1-((4-chlorophenyl)phenylmethyl)piperazine
  • (R)-Cetirizine EP Impurity A
  • (R)-1-[(4-Chlorophenyl)phenylmethyl
  • (R)-Cetirizine EP Impurity A (Levocetirizine Impurity 2)
  • Levocetirizine Chlorobenzhydryl Piperazine (USP)
  • (R)-1-[^a-(4-Chlorophenyl)benzyl]piperazine,97%
  • (R)-(-)-1-[(4-chlorophenyl)phenmethyl]piperazine
  • (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine (Cetirizine Impurity)
  • Chlorobenzhydryl Piperazine (F02160)
  • TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE
  • R(-)-1-[(4-Chlorophenyl)benzyl]piperazine
  • Levocetirizine Impurity 1 (Chlorobenzhydryl piperazine)
  • (-)-1-[( 4-ChIorophenyI)PhenyImethyI] Piperazine
  • (R)-Cetirizine EP Impurity A ((R)-Hydroxyzine USP Related Compound A)
  • (R)-N-(4-Chlorobenzyl hydryl) piperazine
  • (R)-1-[(4-chlorophenyl)phenyl methyl] Piperazine (Intermediate of Levocetirizine )
  • (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine (-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
  • 300543-56-0
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Pharmaceutical Intermediates