(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Product Name: (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
CAS No.: 300543-56-0
Chemical Name: (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
Synonyms: Levocetirizine Impurity A;Levocetirizine Impurity 2;(R)-Cetirizine EP Impurity A;(R)-1-[(4-Chlorophenyl)phenylmethyl;(R)-1-(p-Chlorobenzhydryl)piperazine;Chlorobenzhydryl Piperazine (F02160);(R)-N-(4-Chlorobenzyl hydryl) piperazine;R(-)-1-[(4-Chlorophenyl)benzyl]piperazine;(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE;(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine
CBNumber: CB2299774
Molecular Formula: C17H19ClN2
Formula Weight: 286.8
MOL File: 300543-56-0.mol

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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Property

Melting point:: 91-93oC
Boiling point:: 409.1±0.0 °C(Predicted)
Density: 1.158
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
pka: 8.99±0.10(Predicted)
form: Solid
color: White
PH: 9.38 at 25℃ and 10.07g/L
Water Solubility: Soluble in chloroform, methanol, and dichloromethane. Slightly soluble in water.
InChI: InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/t17-/s3
InChIKey: UZKBSZSTDQSMDR-SCBJWRGWNA-N
SMILES: [C@@H](N1CCNCC1)(C1C=CC=CC=1)C1C=CC(Cl)=CC=1 |&1:0,r|
CAS DataBase Reference: 300543-56-0

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Safety

HS Code: 2933599550

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: H63722
Product name: (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
Packaging: 5g
Price: $424.65
Updated: 2024/03/01

Alfa Aesar

Product number: H63722
Product name: (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
Packaging: 1g
Price: $99.9
Updated: 2023/06/20

Alfa Aesar

Product number: H63722
Product name: (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%
Packaging: 250mg
Price: $33.2
Updated: 2023/06/20

TRC

Product number: C379574
Product name: (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
Packaging: 25mg
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 089223
Product name: (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
Packaging: 25g
Price: $168
Updated: 2021/12/16

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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Chemical Properties,Usage,Production

Uses

Intermediate in the production of (R)-Cetirizine (C281106).

Uses

(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine intermediate in the production of (R)-Cetirizine.

Application

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine could be used to synthesize a series of novel derivatives. Most of these derivatives significantly affected both allergic asthma and allergic itching. Meanwhile, in the test of allergic itching, five of the 19 compounds have more potent activities than levocetirizine[1].

References

[1] Lisheng Wang. “Design, synthesis, and anti-allergic activities of novel (R)(-)-1-[(4-chlorophenyl)phenyl methyl]piperazine derivatives.” Medicinal Chemistry Research 21 1 (2010): 124–132.

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Preparation Products And Raw materials

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View Lastest Price from (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Cetirizine Impurity 35 300543-56-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-26

Career Henan Chemica Co

Product: (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-10-28

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

300543-56-0, (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazineRelated Search:

(S)-(+)-Epichlorohydrin Acetic acid, 2-[2-[2-[4-[(4- chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]ethoxy]- Levocetirizine Impurity 4 Levocetirizine amide impurity HCl 1-(o-Chloro-α-phenylbenzyl)piperazine Piperazine D-3-Bromocamphor-8-sulfonic acid ammonium salt

(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE

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TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE

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(-)-1-[( 4-ChIorophenyI)PhenyImethyI] Piperazine

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300543-56-0

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