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Penicillin V potassium salt

Product Name
Penicillin V potassium salt
CAS No.
132-98-9
Chemical Name
Penicillin V potassium salt
Synonyms
pvk;PENICILLIN V;PENICILLIN V POTASSIUM;vk;PHENOXYMETHYLPENICILLIN POTASSIUM;dov-k;dqv-k;vepen;icipen;orapen
CBNumber
CB1713170
Molecular Formula
C16H17KN2O5S
Formula Weight
388.48
MOL File
132-98-9.mol
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Penicillin V potassium salt Property

Melting point:
197-202°C
alpha 
D25 +223° (c = 0.2)
Density 
1.40
storage temp. 
Inert atmosphere,2-8°C
solubility 
Freely soluble in water, practically insoluble in ethanol (96 per cent).
form 
Solid
color 
Sol in water
Water Solubility 
Soluble in water, dimethyl sulfoxide, and methanol.
BRN 
3899451
BCS Class
1 (CLogP), 3 (LogP)
Stability:
Hygroscopic
InChIKey
HCTVWSOKIJULET-LQDWTQKMSA-M
CAS DataBase Reference
132-98-9(CAS DataBase Reference)
EPA Substance Registry System
Penicillin V Potassium (132-98-9)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-42/43
Safety Statements 
22-26-36/37-45
WGK Germany 
3
RTECS 
XH9275000
TSCA 
Yes
HS Code 
29411099
Hazardous Substances Data
132-98-9(Hazardous Substances Data)
Toxicity
LD50 orally in rats: >1040 mg/kg (Goldenthal)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2644
Product name
Penicillin V Potassium
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500MG
Price
$170
Updated
2024/03/01
Sigma-Aldrich
Product number
46616
Product name
Penicillin V potassium salt
Purity
VETRANAL
Packaging
250mg
Price
$168
Updated
2024/03/01
Sigma-Aldrich
Product number
1504503
Product name
Penicillin V potassium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
P1382
Product name
Phenoxymethylpenicillinic acid potassium salt
Purity
potency: 1444-1536?units per mg
Packaging
10000000units
Price
$90.5
Updated
2022/05/15
Alfa Aesar
Product number
J62442
Product name
Penicillin V potassium salt
Packaging
10g
Price
$59.2
Updated
2024/03/01
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Penicillin V potassium salt Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Oracilline ,Theraplix ,France ,1954

Uses

Penicillin V Potassium bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication. It inhibits biosynthesis of cell-wall mucopeptide. It is used to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Uses

Penicillin antibacterial.

Definition

ChEBI: Phenoxymethylpenicillin potassium is an organic potassium salt. It contains a phenoxymethylpenicillin(1-).

Application

Phenoxymethylpenicillin potassium was first obtained at Lilly Research Laboratories in 1948, following the addition of phenoxyacetic acid to a culture of Penicillium chrysogenum. Its industrial-scale production was established in 1953. Its usefulness as an orally active penicillin was suggested by Spitzy et al. in 1955. It is less hygroscopic and much more stable against gastric acid than benzylpenicillin, and it has been used orally for therapy of infections caused by Streptococcus, Staphylococcus, and other gram-positive bacteria as well as Neisseria and Leptospira.

Manufacturing Process

The following description is taken from US Patent 2,941,995. A solution of phenoxyacetyl chloride (360 mg) in dry acetone (5 ml) was added dropwise during 10 minutes to a stirred solution of 6-aminopenicillanic acid (450 mg, approximately 75% pure) in 3% aqueous bicarbonate (18 ml), and acetone (12 ml). When addition was complete the mixture was stirred at room temperature for 30 minutes and then extracted with ether (30 ml in 3 portions), only the aqueous phase being retained. This aqueous solution was covered with butanol (5 ml) and adjusted to pH 2 by the addition of N hydrochloric acid. After separating the layers, the aqueous phase was extracted with two 2.5 ml portions of butanol, adjusting to pH 2 each time. The combined butanol solutions (which at this stage contained the free penicillanic acid) were washed with water (3 x 2 ml) and then shaken with water (10 ml) to which sufficient 3% sodium bicarbonate solution was added to bring the aqueous phase to pH 7. The butanol solution was further extracted with two 5 ml portions of water to each of which was added enough bicarbonate solution to produce an aqueous phase of pH 7. The combined aqueous solutions were washed with ether (20 ml) and then evaporated at low temperature and pressure to leave the crude sodium salt of phenoxymethyl penicillin which, after drying in a vacuum desiccator, was obtained as a slightly hygroscopic powder (591 mg).

brand name

V-Cillin(Lilly).

Therapeutic Function

Antibacterial

General Description

Odorless white crystalline powder. Slightly bitter taste. pH (0.5% aqueous solution) 5 to 7.5.

Air & Water Reactions

Water soluble.

Reactivity Profile

Penicillin V potassium salt is the potassium salt of penicillin v. Penicillin V potassium salt is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents. Penicillin V potassium salt is also incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides. Other incompatibilities include reducing agents, alcohols, other hydroxy compounds, self-emulsifying stearyl alcohol, emulsifying wax, lanolin, crude cholinesterated bases, glycol, sugars, amines, aminacrine hydrochloride, ephedrine, procaine, rubber tubing, thiamine hydrochloride, zinc oxide, oxidized cellulose, iodine, iodides, thiols, chlorocresol and resorcinol. Penicillin V potassium salt may also be incompatible with naphthalene oils and vitamin B.

Fire Hazard

Flash point data for Penicillin V potassium salt are not available; however, Penicillin V potassium salt is probably combustible.

Safety Profile

Moderately toxic by ingestion, intramuscular, intraperitoneal, and intravenous routes. Human mutation data reported. Questionable carcinogen with no experimental evidence. When heated to decomposition it emits very toxic fumes of NOx, K2O, and SOx. Used

Penicillin V potassium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Penicillin V potassium salt Suppliers

Kunming jida pharmaceutical co. LTD
Tel
0871-68356968 13000000000
Fax
86-0871-6835699
Email
jidamd@jida.com.cn
Country
China
ProdList
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J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
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Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
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Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
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Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
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View Lastest Price from Penicillin V potassium salt manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Penicillin V Potassium 132-98-9
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-15
Henan Suikang Pharmaceutical Co.,Ltd.
Product
Penicillin V potassium salt 132-98-9
Price
US $0.00/bou
Min. Order
40bou
Purity
≥95%
Supply Ability
10000bou
Release date
2024-04-23
Hebei Weibang Biotechnology Co., Ltd
Product
Penicillin V Potassium 132-98-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2023-03-17

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