Penicillin V potassium salt

ChemicalBook > CAS DataBase List > Penicillin V potassium salt

Penicillin V potassium salt

Product Name: Penicillin V potassium salt
CAS No.: 132-98-9
Chemical Name: Penicillin V potassium salt
Synonyms: pvk;PENICILLIN V;PENICILLIN V POTASSIUM;vk;PHENOXYMETHYLPENICILLIN POTASSIUM;dov-k;dqv-k;vepen;icipen;orapen
CBNumber: CB1713170
Molecular Formula: C16H17KN2O5S
Formula Weight: 388.48
MOL File: 132-98-9.mol

Less

Penicillin V potassium salt Property

Melting point:: 197-202°C
alpha: D25 +223° (c = 0.2)
Density: 1.40
storage temp.: Inert atmosphere,2-8°C
solubility: Freely soluble in water, practically insoluble in ethanol (96 per cent).
color: Sol in water
Water Solubility: Soluble in water, dimethyl sulfoxide, and methanol.
BRN: 3899451
BCS Class: 1 (CLogP), 3 (LogP)
Stability:: Hygroscopic
InChIKey: HCTVWSOKIJULET-LQDWTQKMSA-M
CAS DataBase Reference: 132-98-9(CAS DataBase Reference)
EPA Substance Registry System: Penicillin V Potassium (132-98-9)

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-42/43
Safety Statements: 22-26-36/37-45
WGK Germany: 3
RTECS: XH9275000
TSCA: Yes
HS Code: 29411099
Hazardous Substances Data: 132-98-9(Hazardous Substances Data)
Toxicity: LD50 orally in rats: >1040 mg/kg (Goldenthal)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2644
Product name: Penicillin V Potassium
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500MG
Price: $170
Updated: 2024/03/01

Sigma-Aldrich

Product number: 46616
Product name: Penicillin V potassium salt
Purity: VETRANAL
Packaging: 250mg
Price: $168
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1504503
Product name: Penicillin V potassium
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: P1382
Product name: Phenoxymethylpenicillinic acid potassium salt
Purity: potency: 1444-1536?units per mg
Packaging: 10000000units
Price: $90.5
Updated: 2022/05/15

Alfa Aesar

Product number: J62442
Product name: Penicillin V potassium salt
Packaging: 10g
Price: $59.2
Updated: 2024/03/01

Less

Penicillin V potassium salt Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Oracilline ,Theraplix ,France ,1954

Uses

Penicillin V Potassium bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication. It inhibits biosynthesis of cell-wall mucopeptide. It is used to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Uses

Penicillin antibacterial.

Definition

ChEBI: Phenoxymethylpenicillin potassium is an organic potassium salt. It contains a phenoxymethylpenicillin(1-).

Application

Phenoxymethylpenicillin potassium was first obtained at Lilly Research Laboratories in 1948, following the addition of phenoxyacetic acid to a culture of Penicillium chrysogenum. Its industrial-scale production was established in 1953. Its usefulness as an orally active penicillin was suggested by Spitzy et al. in 1955. It is less hygroscopic and much more stable against gastric acid than benzylpenicillin, and it has been used orally for therapy of infections caused by Streptococcus, Staphylococcus, and other gram-positive bacteria as well as Neisseria and Leptospira.

Manufacturing Process

The following description is taken from US Patent 2,941,995. A solution of phenoxyacetyl chloride (360 mg) in dry acetone (5 ml) was added dropwise during 10 minutes to a stirred solution of 6-aminopenicillanic acid (450 mg, approximately 75% pure) in 3% aqueous bicarbonate (18 ml), and acetone (12 ml). When addition was complete the mixture was stirred at room temperature for 30 minutes and then extracted with ether (30 ml in 3 portions), only the aqueous phase being retained. This aqueous solution was covered with butanol (5 ml) and adjusted to pH 2 by the addition of N hydrochloric acid. After separating the layers, the aqueous phase was extracted with two 2.5 ml portions of butanol, adjusting to pH 2 each time. The combined butanol solutions (which at this stage contained the free penicillanic acid) were washed with water (3 x 2 ml) and then shaken with water (10 ml) to which sufficient 3% sodium bicarbonate solution was added to bring the aqueous phase to pH 7. The butanol solution was further extracted with two 5 ml portions of water to each of which was added enough bicarbonate solution to produce an aqueous phase of pH 7. The combined aqueous solutions were washed with ether (20 ml) and then evaporated at low temperature and pressure to leave the crude sodium salt of phenoxymethyl penicillin which, after drying in a vacuum desiccator, was obtained as a slightly hygroscopic powder (591 mg).

brand name

V-Cillin(Lilly).

Therapeutic Function

Antibacterial

General Description

Odorless white crystalline powder. Slightly bitter taste. pH (0.5% aqueous solution) 5 to 7.5.

Air & Water Reactions

Water soluble.

Reactivity Profile

Penicillin V potassium salt is the potassium salt of penicillin v. Penicillin V potassium salt is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents. Penicillin V potassium salt is also incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides. Other incompatibilities include reducing agents, alcohols, other hydroxy compounds, self-emulsifying stearyl alcohol, emulsifying wax, lanolin, crude cholinesterated bases, glycol, sugars, amines, aminacrine hydrochloride, ephedrine, procaine, rubber tubing, thiamine hydrochloride, zinc oxide, oxidized cellulose, iodine, iodides, thiols, chlorocresol and resorcinol. Penicillin V potassium salt may also be incompatible with naphthalene oils and vitamin B.

Fire Hazard

Flash point data for Penicillin V potassium salt are not available; however, Penicillin V potassium salt is probably combustible.

Safety Profile

Moderately toxic by ingestion, intramuscular, intraperitoneal, and intravenous routes. Human mutation data reported. Questionable carcinogen with no experimental evidence. When heated to decomposition it emits very toxic fumes of NOx, K2O, and SOx. Used

Penicillin V potassium salt Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Penicillin V potassium salt Suppliers

Austria 1 Belgium 1 Brazil 2 Canada 1 China 227 Czech Republic 1 Europe 2 France 1 Germany 9 India 13 Japan 1 Poland 1 Slovakia 2 South Korea 2 Spain 2 Switzerland 2 The Netherlands 1 United Kingdom 10 United States 27 Venezuela 1 Global 307

Kunming jida pharmaceutical co. LTD

Tel: 0871-68356968 13000000000
Fax: 86-0871-6835699
Email: jidamd@jida.com.cn
Country: China
ProdList: 12
Advantage: 58

Wuhan Xinru Chemical Industry Co., Ltd

Tel: 15927387915
Email: 2162228368@qq.com
Country: China
ProdList: 3409
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4550
Advantage: 62

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2893
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3924
Advantage: 50

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17982
Advantage: 56

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4951
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15878
Advantage: 55

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8147
Advantage: 55

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9503
Advantage: 50

Watson Biotechnology Co.,Ltd

Tel: 027-027-59207879 18140587686
Fax: QQ：1972026995
Email: kf@3600chem.com
Country: China
ProdList: 4699
Advantage: 55

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4515
Advantage: 55

Hangzhou Dingyan Chem Co., LTD

Tel: 0571-0571-87157530-8001-8003 18008611859
Fax: 0571-87156470
Email: sales@dingyanchem.com
Country: China
ProdList: 1997
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel: 025-57798860
Email: sales@njromanme.com
Country: China
ProdList: 4534
Advantage: 58

Shanghai ChengShao Biological Technology Co., Ltd.

Tel: 021-61847300 13341622919
Fax: 021-61847300
Email: shcss01@163.com
Country: China
ProdList: 4809
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13360
Advantage: 58

Shanghai Civic Chemical Technology Co., Ltd.

Tel: 021-34053660
Fax: QQ:2881074831
Email: sale2@labgogo.com
Country: China
ProdList: 2018
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1993
Advantage: 55

Anhui kuer Bioengineering Co., Ltd

Tel: 0551-65171243 13810511747
Email: kuer@kuerhuaxue.com
Country: China
ProdList: 2997
Advantage: 55

Guangzhou Kafen Biotech Co.,Ltd

Tel: 18029243487 2355327168
Fax: 020-31121510
Email: gy@yccreate.com
Country: China
ProdList: 4753
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3979
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9980
Advantage: 55

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9506
Advantage: 60

Jinan Londi Medical Technology Co., LTD

Tel: 0531-88996911 15628983711
Fax: 0531-88996911
Email: 3305202763@qq.com
Country: China
ProdList: 125
Advantage: 58

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10335
Advantage: 58

Guangzhou LES biological Technology Co.,Ltd.

Tel: 13672434928
Fax: -
Email: 3307355104@qq.com
Country: China
ProdList: 3650
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15952
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 1994
Advantage: 64

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17997
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 15503
Advantage: 58

Foshan DaoQi Biological Co., Ltd.

Tel: 18062666947
Fax: 18062666959
Email: 2355880548@qq.com
Country: China
ProdList: 4229
Advantage: 58

Less

View Lastest Price from Penicillin V potassium salt manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Penicillin V potassium salt 132-98-9
Price: US $0.00/bou
Min. Order: 40bou
Purity: ≥95%
Supply Ability: 10000bou
Release date: 2024-04-23

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Penicillin V potassium 132-98-9
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.912%
Supply Ability: 10ton
Release date: 2024-04-22

Shaanxi Haibo Biotechnology Co., Ltd

Product: Penicillin V Potassium 132-98-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-09-04

132-98-9, Penicillin V potassium saltRelated Search:

Penicillin G sodium salt Potassium Acetate Dimethyl fumarate Potassium bromate Penicillin G potassium salt N,N-Dimethylformamide Potassium persulfate Dimethyl carbonate Sodium 1-heptanesulfonate N,N-Dimethylacetamide Potassium chloride phenoxybenzamine Potassium Citrate Potassium sorbate Potassium iodide PENICILLIN V Heptane Losartan potassium

Penicillin V potassium salt, Phenoxymethylpenicillinic acid potassium salt

PHENOXYMETHYLPENICILLINIC ACID POTASSIUM SALT

PHENOXYMETHYLPENICILLIN K+ SALT

PHENOXYMETHYLPENICILLIN POTASSIUM

PHENOXYMETHYL PENICILLIN POTASSIUM SALT

PENICILLIN VK

PENICILLIN V POTASSIUM

PENICILLIN V POTASSIUM SALT

PENICILLIN V

PENICILLINE V POTASSIUM SALT

4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-7-oxo-6-((ph

abicyclo[3.2.0]heptane-2-carboxylate

calciopenk

cliacil

compocillin-vk

d-alpha-phenoxymethylpenicillinateksalt

distakapsv-k

distaquainev-k

dov-k

dowpenv-k

dqv-k

fenoxypen

icipen

isocillin

ispenoral

kavepenin

ledercillinvk

megacillinoral

monopotassium(2s,5r,6r)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-az

monopotassiumsalt,(2s-(2alpha,5alpha,6beta))-enoxyacetyl)amino)

monopotassiumsalt,[2s-(2alpha,5alpha,6beta)]-noxyacetyl)amino]

oracil-vk

orapen

ospeneff

pedipen

penagen

penaparvk

pencompren

penicillinpotassiumphenoxymethyl

pen-vee-k

pen-vee-kpowder

penvikal

pen-v-kpowder

pfizerpenvk

phenoxymethylpenicillinicacid*potassium

potassiumpenicillinv

potassiumpenicillinvsalt

potassiumphenoxymethylpenicillin

primcillin

pvk

qidpenvk

robicillinvk

rocillin-vk

roscopenin

sk-penicillinvk

stabillinvksyrup125

stabillinvksyrup62.5

sumapenvk