Penicillin V potassium salt

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Penicillin V potassium salt

Product Name: Penicillin V potassium salt
CAS No.: 132-98-9
Chemical Name: Penicillin V potassium salt
Synonyms: pvk;PENICILLIN V;PENICILLIN V POTASSIUM;vk;PHENOXYMETHYLPENICILLIN POTASSIUM;dov-k;dqv-k;vepen;icipen;orapen
CBNumber: CB1713170
Molecular Formula: C16H17KN2O5S
Formula Weight: 388.48
MOL File: 132-98-9.mol

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Penicillin V potassium salt Property

Melting point:: 197-202°C
alpha: D25 +223° (c = 0.2)
Density: 1.40
storage temp.: Inert atmosphere,2-8°C
solubility: Freely soluble in water, practically insoluble in ethanol (96 per cent).
form: Solid
color: Sol in water
Water Solubility: Soluble in water, dimethyl sulfoxide, and methanol.
BRN: 3899451
BCS Class: 1 (CLogP), 3 (LogP)
Stability:: Hygroscopic
InChIKey: HCTVWSOKIJULET-LQDWTQKMSA-M
CAS DataBase Reference: 132-98-9(CAS DataBase Reference)
EPA Substance Registry System: Penicillin V Potassium (132-98-9)

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Safety

Hazard Codes: Xn
Risk Statements: 22-42/43
Safety Statements: 22-26-36/37-45
WGK Germany: 3
RTECS: XH9275000
TSCA: Yes
HS Code: 29411099
Hazardous Substances Data: 132-98-9(Hazardous Substances Data)
Toxicity: LD50 orally in rats: >1040 mg/kg (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2644
Product name: Penicillin V Potassium
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500MG
Price: $170
Updated: 2024/03/01

Sigma-Aldrich

Product number: 46616
Product name: Penicillin V potassium salt
Purity: VETRANAL
Packaging: 250mg
Price: $168
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1504503
Product name: Penicillin V potassium
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: P1382
Product name: Phenoxymethylpenicillinic acid potassium salt
Purity: potency: 1444-1536?units per mg
Packaging: 10000000units
Price: $90.5
Updated: 2022/05/15

Alfa Aesar

Product number: J62442
Product name: Penicillin V potassium salt
Packaging: 10g
Price: $59.2
Updated: 2024/03/01

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Penicillin V potassium salt Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Oracilline ,Theraplix ,France ,1954

Uses

Penicillin V Potassium bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication. It inhibits biosynthesis of cell-wall mucopeptide. It is used to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Uses

Penicillin antibacterial.

Definition

ChEBI: Phenoxymethylpenicillin potassium is an organic potassium salt. It contains a phenoxymethylpenicillin(1-).

Application

Phenoxymethylpenicillin potassium was first obtained at Lilly Research Laboratories in 1948, following the addition of phenoxyacetic acid to a culture of Penicillium chrysogenum. Its industrial-scale production was established in 1953. Its usefulness as an orally active penicillin was suggested by Spitzy et al. in 1955. It is less hygroscopic and much more stable against gastric acid than benzylpenicillin, and it has been used orally for therapy of infections caused by Streptococcus, Staphylococcus, and other gram-positive bacteria as well as Neisseria and Leptospira.

Manufacturing Process

The following description is taken from US Patent 2,941,995. A solution of phenoxyacetyl chloride (360 mg) in dry acetone (5 ml) was added dropwise during 10 minutes to a stirred solution of 6-aminopenicillanic acid (450 mg, approximately 75% pure) in 3% aqueous bicarbonate (18 ml), and acetone (12 ml). When addition was complete the mixture was stirred at room temperature for 30 minutes and then extracted with ether (30 ml in 3 portions), only the aqueous phase being retained. This aqueous solution was covered with butanol (5 ml) and adjusted to pH 2 by the addition of N hydrochloric acid. After separating the layers, the aqueous phase was extracted with two 2.5 ml portions of butanol, adjusting to pH 2 each time. The combined butanol solutions (which at this stage contained the free penicillanic acid) were washed with water (3 x 2 ml) and then shaken with water (10 ml) to which sufficient 3% sodium bicarbonate solution was added to bring the aqueous phase to pH 7. The butanol solution was further extracted with two 5 ml portions of water to each of which was added enough bicarbonate solution to produce an aqueous phase of pH 7. The combined aqueous solutions were washed with ether (20 ml) and then evaporated at low temperature and pressure to leave the crude sodium salt of phenoxymethyl penicillin which, after drying in a vacuum desiccator, was obtained as a slightly hygroscopic powder (591 mg).

brand name

V-Cillin(Lilly).

Therapeutic Function

Antibacterial

General Description

Odorless white crystalline powder. Slightly bitter taste. pH (0.5% aqueous solution) 5 to 7.5.

Air & Water Reactions

Water soluble.

Reactivity Profile

Penicillin V potassium salt is the potassium salt of penicillin v. Penicillin V potassium salt is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents. Penicillin V potassium salt is also incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides. Other incompatibilities include reducing agents, alcohols, other hydroxy compounds, self-emulsifying stearyl alcohol, emulsifying wax, lanolin, crude cholinesterated bases, glycol, sugars, amines, aminacrine hydrochloride, ephedrine, procaine, rubber tubing, thiamine hydrochloride, zinc oxide, oxidized cellulose, iodine, iodides, thiols, chlorocresol and resorcinol. Penicillin V potassium salt may also be incompatible with naphthalene oils and vitamin B.

Fire Hazard

Flash point data for Penicillin V potassium salt are not available; however, Penicillin V potassium salt is probably combustible.

Safety Profile

Moderately toxic by ingestion, intramuscular, intraperitoneal, and intravenous routes. Human mutation data reported. Questionable carcinogen with no experimental evidence. When heated to decomposition it emits very toxic fumes of NOx, K2O, and SOx. Used

Penicillin V potassium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Penicillin V potassium salt manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Penicillin V potassium salt 132-98-9
Price: US $0.00/bou
Min. Order: 40bou
Purity: ≥95%
Supply Ability: 10000bou
Release date: 2024-04-23

Hebei Weibang Biotechnology Co., Ltd

Product: Penicillin V Potassium 132-98-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

Hebei Chuanghai Biotechnology Co,.LTD

Product: Penicillin V Potassium 132-98-9
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-15

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Penicillin V potassium salt, Phenoxymethylpenicillinic acid potassium salt

PHENOXYMETHYLPENICILLINIC ACID POTASSIUM SALT

PHENOXYMETHYLPENICILLIN K+ SALT

PHENOXYMETHYLPENICILLIN POTASSIUM

PHENOXYMETHYL PENICILLIN POTASSIUM SALT

PENICILLIN VK

PENICILLIN V POTASSIUM

PENICILLIN V POTASSIUM SALT

PENICILLIN V

PENICILLINE V POTASSIUM SALT

4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-7-oxo-6-((ph

abicyclo[3.2.0]heptane-2-carboxylate

calciopenk

cliacil

compocillin-vk

d-alpha-phenoxymethylpenicillinateksalt

distakapsv-k

distaquainev-k

dov-k

dowpenv-k

dqv-k

fenoxypen

icipen

isocillin

ispenoral

kavepenin

ledercillinvk

megacillinoral

monopotassium(2s,5r,6r)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-az

monopotassiumsalt,(2s-(2alpha,5alpha,6beta))-enoxyacetyl)amino)

monopotassiumsalt,[2s-(2alpha,5alpha,6beta)]-noxyacetyl)amino]

oracil-vk

orapen

ospeneff

pedipen

penagen

penaparvk

pencompren

penicillinpotassiumphenoxymethyl

pen-vee-k

pen-vee-kpowder

penvikal

pen-v-kpowder

pfizerpenvk

phenoxymethylpenicillinicacid*potassium

potassiumpenicillinv

potassiumpenicillinvsalt

potassiumphenoxymethylpenicillin

primcillin

pvk

qidpenvk

robicillinvk

rocillin-vk

roscopenin

sk-penicillinvk

stabillinvksyrup125

stabillinvksyrup62.5

sumapenvk