9-Azabicyclo[3.3.1]nonan-3-one, 9-(phenylmethyl)-
- Product Name
- 9-Azabicyclo[3.3.1]nonan-3-one, 9-(phenylmethyl)-
- CAS No.
- 2291-58-9
- Chemical Name
- 9-Azabicyclo[3.3.1]nonan-3-one, 9-(phenylmethyl)-
- Synonyms
- 9-Benzyl-3-oxo-9-azabicyc...;N-Benzylnorpseudopelletierine;9-Benzyl-9-aza-bicyclo3.3.1non-3-one;9-Benzyl-3-oxo-9-azabicyclo[3.3.1]nonane;9-(phenylmethyl)-9-azabicyclo[3.3.1]nonan-3-one;9-Azabicyclo[3.3.1]nonan-3-one, 9-(phenylmethyl)-;9-Benzyl-9-az9-Benzyl-9-azabicyclo[3.3.1]nonan-3-oneabicyclo[3.3.1]nonan-3-one
- CBNumber
- CB02552862
- Molecular Formula
- C15H19NO
- Formula Weight
- 229.32
- MOL File
- 2291-58-9.mol
9-Azabicyclo[3.3.1]nonan-3-one, 9-(phenylmethyl)- Property
- Melting point:
- 72-75℃
- Boiling point:
- 165-169 °C(Press: 0.2 Torr)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.04±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2921309990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B230750
- Product name
- 9-Benzyl-9-azabicyclo[3.3.1]nonan-3-one
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 4H56-1-LF
- Product name
- 9-Benzyl-3-oxo-9-azabicyclo[3.3.1]nonane
- Packaging
- 5G
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FB163632
- Product name
- 9-Benzyl-9-azabicyclo[3.3.1]nonan-3-one
- Packaging
- 2g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 113432
- Product name
- 9-Benzyl-3-oxo-9-azabicyclo[3.3.1]nonane
- Packaging
- 5g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- FB163632
- Product name
- 9-Benzyl-9-azabicyclo[3.3.1]nonan-3-one
- Packaging
- 5G
- Price
- $300
- Updated
- 2021/12/16
9-Azabicyclo[3.3.1]nonan-3-one, 9-(phenylmethyl)- Chemical Properties,Usage,Production
Synthesis
542-05-2
111-30-8
100-46-9
2291-58-9
1. Benzylamine (5.0 g, 47 mmol) and Na?HPO?-12H?O (5.0 g) were dissolved in 50 mL of water and cooled in an ice water bath. 2. a 25% aqueous solution of 1,3-acetone dicarboxylic acid (8 g, 20 mmol, 1.0 eq.) was slowly added with stirring. 3. After the dropwise addition was completed within 60 minutes, the reaction mixture was allowed to warm slowly to room temperature and stirring was continued for 24 hours. 4. Upon completion of the reaction, the pH was adjusted to 3 with concentrated hydrochloric acid. 5. The reaction mixture was transferred to an oil bath at 50 °C, stirred for 2 hours and then cooled to room temperature. 6. The pH was adjusted to 10 with 20% NaOH solution, then extracted twice with dichloromethane and the organic phases were combined. 7. The organic phase was washed once with saturated brine and concentrated under reduced pressure to give a yellow solid crude product of 9-benzyl-9-azabicyclo[3.3.1]nonan-3-one. 8. The crude product was purified by crystallization with a solvent mixture of ethyl acetate and petroleum ether in the ratio of 1:5 by volume, and 9 g of light yellow solid product was obtained after filtration in 91% yield.
References
[1] Patent: CN106366082, 2017, A. Location in patent: Paragraph 0047-0049
[2] Patent: WO2012/112851, 2012, A2. Location in patent: Page/Page column 54
[3] Chemical and Pharmaceutical Bulletin, 2011, vol. 59, # 12, p. 1570 - 1573
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 11, p. 3159 - 3171
[5] Patent: EP2594550, 2013, A1. Location in patent: Paragraph 0037; 0038
9-Azabicyclo[3.3.1]nonan-3-one, 9-(phenylmethyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 9-Azabicyclo[3.3.1]nonan-3-one, 9-(phenylmethyl)- manufacturers
- Product
- 9-Azabicyclo[3.3.1]nonan-3-one, 9-(phenylmethyl)- 2291-58-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-08
- Product
- 9-Benzyl-3-oxo-9-azabicyc... 2291-58-9
- Price
- US $0.01/KG
- Min. Order
- 500g
- Purity
- 98%; 99%
- Supply Ability
- 500g；1kg； 10kg; 25kg
- Release date
- 2020-01-08