4-broMo-2-(difluoroMethoxy)pyridine

Product Name: 4-broMo-2-(difluoroMethoxy)pyridine
CAS No.: 832735-56-5
Chemical Name: 4-broMo-2-(difluoroMethoxy)pyridine
Synonyms: 4-broMo-2-(difluoroMethoxy)pyridine;Pyridine,4-bromo-2-(difluoromethoxy)-
CBNumber: CB02553708
Molecular Formula: C6H4BrF2NO
Formula Weight: 224
MOL File: 832735-56-5.mol

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4-broMo-2-(difluoroMethoxy)pyridine Property

Boiling point:: 198.6±35.0 °C(Predicted)
Density: 1.670±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0?+-.0.10(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C6H4BrF2NO/c7-4-1-2-10-5(3-4)11-6(8)9/h1-3,6H
InChIKey: QKZHLBZNEBCOLM-UHFFFAOYSA-N
SMILES: C1(OC(F)F)=NC=CC(Br)=C1
CAS DataBase Reference: 832735-56-5

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B292500
Product name: 4-Bromo-2-(difluoromethoxy)pyridine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC201316
Product name: 4-Bromo-2-(difluoromethoxy)pyridine
Purity: 97%
Packaging: 100mg
Price: $56
Updated: 2021/12/16

Apolloscientific

Product number: PC201316
Product name: 4-Bromo-2-(difluoromethoxy)pyridine
Purity: 97%
Packaging: 250mg
Price: $89
Updated: 2021/12/16

AK Scientific

Product number: 7622DA
Product name: 4-Bromo-2-(difluoromethoxy)pyridine
Packaging: 100mg
Price: $146
Updated: 2021/12/16

AK Scientific

Product number: 7622DA
Product name: 4-Bromo-2-(difluoromethoxy)pyridine
Packaging: 1g
Price: $415
Updated: 2021/12/16

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4-broMo-2-(difluoroMethoxy)pyridine Chemical Properties,Usage,Production

Synthesis

36953-37-4

1895-39-2

832735-56-5

General procedure for the synthesis of 4-bromo-2-difluoromethoxypyridine from 4-bromo-2-hydroxypyridine and sodium 2-chloro-2,2-difluoroacetate: Example 26i: 4-Bromo-2-hydroxypyridine (200 mg, 1.15 mmol) and sodium 2-chloro-2,2-difluoroacetate (210 mg, 1.38 mmol) were suspended in dry acetonitrile (8 mL). The reaction mixture was heated to reflux overnight and subsequently cooled to room temperature. The reaction mixture was extracted directly with pentane (3 × 5 mL). The organic phases were combined and concentrated to afford 219 mg (85% yield) of 4-bromo-2-difluoromethoxypyridine. Product characterization data were as follows: 1H-NMR (500 MHz, DMSO-d6) δ 8.18 (d, 1H), 7.70 (t, 1H), 7.56 (d, 1H), 7.50 (s, 1H); mass spectra (CI+) m/z 226, 224 [M + 1]+.

References

[1] Patent: US2010/125087, 2010, A1. Location in patent: Page/Page column 21
[2] Patent: WO2018/2760, 2018, A1. Location in patent: Page/Page column 100

4-broMo-2-(difluoroMethoxy)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-broMo-2-(difluoroMethoxy)pyridine Suppliers

China 74 India 1 United States 5 Global 80

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832735-56-5, 4-broMo-2-(difluoroMethoxy)pyridineRelated Search:

4-broMo-2-(difluoroMethoxy)pyridine

Pyridine,4-bromo-2-(difluoromethoxy)-

832735-56-5