Ro 67-7476

ChemicalBook > CAS DataBase List > Ro 67-7476

Product Name: Ro 67-7476
CAS No.: 298690-60-5
Chemical Name: Ro 67-7476
Synonyms: Ro 67-7476;RO67-7476;RO-67-7476;(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine;Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-;excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor
CBNumber: CB02561080
Molecular Formula: C17H18FNO2S
Formula Weight: 319.39
MOL File: 298690-60-5.mol

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Ro 67-7476 Property

Boiling point:: 452.9±55.0 °C(Predicted)
Density: 1.268±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO:30.0(Max Conc. mg/mL);93.9(Max Conc. mM)
pka: -5.53±0.40(Predicted)
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11993
Product name: Ro 67-7476
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11993
Product name: Ro 67-7476
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 11993
Product name: Ro 67-7476
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 11993
Product name: Ro 67-7476
Packaging: 25mg
Price: $494
Updated: 2024/03/01

Tocris

Product number: 4346
Product name: Ro67-7476
Purity: ≥99%(HPLC)
Packaging: 10
Price: $212
Updated: 2021/12/16

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Ro 67-7476 Chemical Properties,Usage,Production

Description

Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC₅₀ = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC₅₀ = 163.3 nM).

Uses

Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator.

storage

Store at RT

Ro 67-7476 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 67-7476 Suppliers

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298690-60-5, Ro 67-7476Related Search:

(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine

RO67-7476;RO-67-7476

Ro 67-7476

Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-

excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor

298690-60-5