ChemicalBook > CAS DataBase List > Ro 67-7476

Ro 67-7476

Product Name
Ro 67-7476
CAS No.
298690-60-5
Chemical Name
Ro 67-7476
Synonyms
Ro 67-7476;RO67-7476;RO-67-7476;Ro 67-7476, 10 mM in DMSO;(S)-2-(4-Fluorophenyl)-1-tosylpyrrolidine;(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine;Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-;excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor
CBNumber
CB02561080
Molecular Formula
C17H18FNO2S
Formula Weight
319.39
MOL File
298690-60-5.mol
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Ro 67-7476 Property

Boiling point:
452.9±55.0 °C(Predicted)
Density 
1.268±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO:30.0(Max Conc. mg/mL);93.9(Max Conc. mM)
pka
-5.53±0.40(Predicted)
form 
Powder
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11993
Product name
Ro 67-7476
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11993
Product name
Ro 67-7476
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
11993
Product name
Ro 67-7476
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
11993
Product name
Ro 67-7476
Packaging
25mg
Price
$494
Updated
2024/03/01
Tocris
Product number
4346
Product name
Ro67-7476
Purity
≥99%(HPLC)
Packaging
10
Price
$212
Updated
2021/12/16
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Ro 67-7476 Chemical Properties,Usage,Production

Description

Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM).

Uses

Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator.

IC 50

mGluR1a: 60.1 nM (EC50)

storage

Store at RT

References

[1] F. KNOFLACH. Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site[J]. Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 1: 13402-13407. DOI: 10.1073/pnas.231358298
[2] DOUGLAS J. SHEFFLER  P. J C. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells[J]. Neuropharmacology, 2008, 55 4: Pages 419-427. DOI: 10.1016/j.neuropharm.2008.06.047

Ro 67-7476 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 67-7476 Suppliers

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298690-60-5, Ro 67-7476Related Search:


  • (2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
  • RO67-7476;RO-67-7476
  • Ro 67-7476
  • Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-
  • excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor
  • Ro 67-7476, 10 mM in DMSO
  • (S)-2-(4-Fluorophenyl)-1-tosylpyrrolidine
  • 298690-60-5