ChemicalBook > CAS DataBase List > Ro 67-7476
Ro 67-7476
- Product Name
- Ro 67-7476
- CAS No.
- 298690-60-5
- Chemical Name
- Ro 67-7476
- Synonyms
- Ro 67-7476;RO67-7476;RO-67-7476;(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine;Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-;excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor
- CBNumber
- CB02561080
- Molecular Formula
- C17H18FNO2S
- Formula Weight
- 319.39
- MOL File
- 298690-60-5.mol
More
Less
Ro 67-7476 Property
- Boiling point:
- 452.9±55.0 °C(Predicted)
- Density
- 1.268±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO:30.0(Max Conc. mg/mL);93.9(Max Conc. mM)
- pka
- -5.53±0.40(Predicted)
- form
- Powder
More
Less
N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 11993
- Product name
- Ro 67-7476
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11993
- Product name
- Ro 67-7476
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11993
- Product name
- Ro 67-7476
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11993
- Product name
- Ro 67-7476
- Packaging
- 25mg
- Price
- $494
- Updated
- 2024/03/01
Tocris
- Product number
- 4346
- Product name
- Ro67-7476
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $212
- Updated
- 2021/12/16
More
Less
Ro 67-7476 Chemical Properties,Usage,Production
Description
Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM).
Uses
Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator.
storage
Store at RT
Ro 67-7476 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less