6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one

Product Name: 6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one
CAS No.: 98453-60-2
Chemical Name: 6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one
Synonyms: 6-Bromo-4,4-dimethyl-2,3-dihydronaphthalen-1-one;6-Bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one;6-Bromo-3,4-dihydro-4,4-dimethylnaphthalen-1(2H)-one;6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one;1(2H)-Naphthalenone, 6-bromo-3,4-dihydro-4,4-dimethyl-;6-bromo-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one
CBNumber: CB02561262
Molecular Formula: C12H13BrO
Formula Weight: 253.13
MOL File: 98453-60-2.mol

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6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one Property

Melting point:: 48℃
Boiling point:: 335℃
Density: 1.351
Flash point:: 75℃
storage temp.: Sealed in dry,Room Temperature

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0061119
Product name: 6-Bromo-4,4-dimethyl-2,3-dihydronaphthalen-1-one
Packaging: 100mg
Price: $207
Updated: 2021/12/16

ChemScene

Product number: CS-0061119
Product name: 6-Bromo-4,4-dimethyl-2,3-dihydronaphthalen-1-one
Packaging: 250mg
Price: $345
Updated: 2021/12/16

AK Scientific

Product number: 2853AQ
Product name: 6-Bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one
Packaging: 250mg
Price: $479.6
Updated: 2021/12/16

Alichem

Product number: 98453602
Product name: 6-Bromo-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one
Packaging: 100mg
Price: $186.18
Updated: 2021/12/16

Crysdot

Product number: CD12000603
Product name: 6-Bromo-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one
Purity: 97%
Packaging: 250mg
Price: $275
Updated: 2021/12/16

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6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one Chemical Properties,Usage,Production

Synthesis

98453-58-8

98453-60-2

7-Bromo-1,1-dimethyl-1,2,3,4-tetrahydronaphthalene (Compound 2, 1.1 g, 4.62 mmol) was used as a starting material and dissolved in 10 mL of dichloromethane. To this solution was added chromium (VI) oxide (72 mg, 0.46 mmol) and 5 mL of tert-butyl hydroperoxide solution (TBHP). The reaction mixture was stirred at room temperature for 8 hours. Upon completion of the reaction, the mixture was diluted with 20 mL of water and subsequently extracted with ether (3 x 10 mL). The combined organic phases were washed with brine (10 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast chromatography (eluent ratio 90:10 hexane/ethyl acetate) to afford 6-bromo-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one (920 mg, 79% yield) as a white solid. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 7.87 (d, J = 8.1 Hz, 1H), 7.54 (d, J = 2.1 Hz, 1H), 7.42 (dd, J = 2.1, 8.1 Hz, 1H), 2.70 (dd, J = 6.3, 7.5 Hz, 2H), 2.01 (dd, J = 6.3, 7.5 Hz, 2H), 1.38 (s, 6H).

References

[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4345 - 4359
[2] Patent: WO2005/66115, 2005, A2. Location in patent: Page/Page column 19; 21
[3] Patent: US2005/148590, 2005, A1. Location in patent: Page/Page column 23; 24
[4] Tetrahedron, 1985, vol. 41, # 8, p. 1509 - 1516
[5] Patent: WO2004/46096, 2004, A2. Location in patent: Page 24

6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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