KX2-391
- Product Name
- KX2-391
- CAS No.
- 897016-82-9
- Chemical Name
- KX2-391
- Synonyms
- KX 01;CS-234;KX-O1);Tirbanibulin;KX2-391 (KX01);KX2-391 USP/EP/BP;Tirbanibulin, KX2-391;KX2-391（Tirbanibulin）;KX2-391;KX2 391;KX2391;N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide
- CBNumber
- CB02561484
- Molecular Formula
- C26H29N3O3
- Formula Weight
- 431.53
- MOL File
- 897016-82-9.mol
KX2-391 Property
- Boiling point:
- 680.9±55.0 °C(Predicted)
- Density
- 1.169
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥121 mg/mL in DMSO; ≥2.44 mg/mL in EtOH with gentle warming and ultrasonic
- form
- Powder
- pka
- 14.73±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21429
- Product name
- KX2-391
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 21429
- Product name
- KX2-391
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 21429
- Product name
- KX2-391
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $672
- Updated
- 2024/03/01
- Product number
- 21429
- Product name
- KX2-391
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $1151
- Updated
- 2024/03/01
- Product number
- K475000
- Product name
- KX2-391
- Packaging
- 10mg
- Price
- $255
- Updated
- 2021/12/16
KX2-391 Chemical Properties,Usage,Production
Uses
A synthetic, orally bioavailable small molecule and non-ATP competitive Src tyrosine kinase inhibitor with an IC50 of average 72 nM.
Uses
KX2-391 is a Src Inhibitor with efficacy against certain hepatic and leukemia cell lines.
Biological Activity
kx2-391 is a highly selective inhibitor of src kinase with ic50 value of 20nm [1].kx2-391 is a non-atp competitive inhibitor of src. it is the first inhibitor that targets src kinase within the substrate binding site. kx2-391 inhibits src catalyzed trans-phosphorylation of fak, shc, paxillin as well as src kinase autophosphorylation. kx2-391 has no effects on pdgfr, egfr, jak1, jak2 and lck demonstrating it as a selective inhibitor. it is also found to be an inhibitor of tubulin polymerization through binding to the unique confirmation on heterodimeric tubulin. in cellular assays, kx2-391 shows growth inhibition in nih3t3/c-src527f cells and syf/c-src527f cells with gi50 values of 23nm and 39nm, respectively [1, 2].since src acts as a regulator in cell proliferation survival, motility and invasiveness, kx2-391 is potent against a variety of solid tumors and many leukemia tumors. it is shown to inhibit primary tumor growth and to suppress metastasis [2].
target
Src (HuH7)
References
[1] fallah-tafti a, foroumadi a, tiwari r, et al. thiazolyl n-benzyl-substituted acetamide derivatives: synthesis, src kinase inhibitory and anticancer activities. european journal of medicinal chemistry, 2011, 46(10): 4853-4858.
[2] naing a, cohen r, dy g k, et al. a phase i trial of kx2-391, a novel non-atp competitive substrate-pocket-directed src inhibitor, in patients with advanced malignancies. investigational new drugs, 2013, 31(4): 967-973.
KX2-391 Preparation Products And Raw materials
Raw materials
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View Lastest Price from KX2-391 manufacturers
- Product
- KX2-391 897016-82-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10