1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol
- Product Name
- 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol
- CAS No.
- 1256546-72-1
- Chemical Name
- 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol
- Synonyms
- 106435;1,4-Dioxaspiro[4,5]decane-8,8-diMethanol;1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol;[8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol;[8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol - [H18075]
- CBNumber
- CB02563468
- Molecular Formula
- C10H18O4
- Formula Weight
- 202.25
- MOL File
- 1256546-72-1.mol
1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol Property
- Boiling point:
- 347.2±17.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 14.69±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H18O4/c11-7-9(8-12)1-3-10(4-2-9)13-5-6-14-10/h11-12H,1-8H2
- InChIKey
- SXKPJJHMUALAKH-UHFFFAOYSA-N
- SMILES
- O1C2(CCC(CO)(CO)CC2)OCC1
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- CHM0386807
- Product name
- 1,4-DIOXASPIRO[4.5]DECANE-8,8-DIYLDIMETHANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.38
- Updated
- 2021/12/16
- Product number
- 132069
- Product name
- 1,4-Dioxaspiro[4.5]decane-8,8-diyldimethanol
- Purity
- 95%
- Packaging
- 500mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- 132069
- Product name
- 1,4-Dioxaspiro[4.5]decane-8,8-diyldimethanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $810
- Updated
- 2021/12/16
- Product number
- 4815AA
- Product name
- 1,4-Dioxaspiro[4.5]decane-8,8-diyldimethanol
- Packaging
- 1g
- Price
- $1143
- Updated
- 2021/12/16
- Product number
- 2H10-1-98
- Product name
- 1,4-Dioxaspiro[4.5]decane-8,8-dimethanol
- Packaging
- 1g
- Price
- $1360
- Updated
- 2021/12/16
1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol Chemical Properties,Usage,Production
Synthesis
1256546-71-0
1256546-72-1
The synthesis of 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylic acid diethyl ester (Intermediate 3, 128.7 g, 450 mmol) was carried out as a raw material for the synthesis of 1,4-dioxaspiro[4.5]decane-8,8-dimethanol (Intermediate 4). The procedure was as follows: a THF solution (900 mL, 900 mmol) of 1 M lithium aluminum hydride was added to a 3-necked 1 L round-bottomed flask equipped with a thermometer, a dropping funnel, and a nitrogen inlet under nitrogen protection and cooled using a dry ice/acetone bath until the internal temperature was maintained at 10-15 °C. The THF solution (75 mL) of intermediate 3 was added slowly and dropwise over a period of 1 hr. The reaction mixture was gradually brought back to room temperature in a cooling bath and stirred overnight. Subsequently, the mixture was cooled to -5°C and quenched by the slow addition of water (40 mL) under vigorous stirring for 1.5 h. The reaction was carried out during 1.5 h, during which the internal temperature was strictly controlled not to exceed 30°C. Next, 15% NaOH solution (40 mL) and water (40 mL) were added dropwise. The precipitate obtained was filtered through diatomaceous earth and washed with THF (300 mL). The filtrate was concentrated to dryness in vacuum to afford 1,4-dioxaspiro[4.5]decane-8,8-dimethanol (63.3 g) as a white solid. The white filter cake was further extracted with 10% MeOH/CH2Cl2 (2 x 500 mL) to obtain additional product (15.6 g). The total yield was 78.9 g (0.39 mol, 87% yield). The product was characterized by LCMS and NMR: LCMS m/z 203 (M+H), 225 (M+Na); 1H NMR (500MHz, CD3OD) δ ppm 1.49-1.55 (4H, m, 3,5-CH2), 1.59-1.66 (4H, m, 2,6-CH2), 3.49 (4H, s, 9,10-OCH2 ), 3.94 (4H, s, 7,8-OCH2); 13C NMR (126MHz, CD3OD) δ ppm 26.7 (3,5-CH2), 30.3 (2,6-CH2), 38.3 (4-C), 64.2 (7,8-OCH2), 65.4 (9,10-OCH2), 109.2 (1-OCO).
References
[1] Patent: WO2012/78834, 2012, A1. Location in patent: Page/Page column 62-63
[2] Patent: EP3281942, 2018, A1. Location in patent: Paragraph 0156; 0157
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 5, p. 609 - 614
[4] Patent: EP2881394, 2015, A1. Location in patent: Paragraph 0364
[5] Patent: WO2014/153226, 2014, A1. Location in patent: Paragraph 00333
1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol Preparation Products And Raw materials
Raw materials
Preparation Products
1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol Suppliers
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 021-54540637 18621091017
- Fax
- 021-34978309
- sales@amaspharm.com
- Country
- China
- ProdList
- 781
- Advantage
- 62
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 13661411401
- Fax
- 51370935-8011
- yinglv.que@aqbiopharma.com.cn
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4542
- Advantage
- 58
- Tel
- 021-31007982 18019432809
- Fax
- 021-31007982
- info@xrpharma.com
- Country
- China
- ProdList
- 676
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 0371-53765687 18937137882
- Fax
- QQ:2885373884
- 2853979813@qq.com
- Country
- China
- ProdList
- 7992
- Advantage
- 55
View Lastest Price from 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol manufacturers
- Product
- 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol 1256546-72-1
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg-1000kg
- Release date
- 2019-12-25