1-(4-Bromophenyl)-2-methylpropan-1-one
- Product Name
- 1-(4-Bromophenyl)-2-methylpropan-1-one
- CAS No.
- 49660-93-7
- Chemical Name
- 1-(4-Bromophenyl)-2-methylpropan-1-one
- Synonyms
- 1-(4-Bromophenyl)-2-methyl-1-propanone;1-(4-Bromophenyl)-2-methylpropan-1-one;1-Propanone, 1-(4-bromophenyl)-2-methyl-;1-(4-Bromophenyl)-2-methyl-1-propanone - [B93233]
- CBNumber
- CB02563594
- Molecular Formula
- C10H11BrO
- Formula Weight
- 227.1
- MOL File
- 49660-93-7.mol
1-(4-Bromophenyl)-2-methylpropan-1-one Property
- Melting point:
- 18°C(lit.)
- Boiling point:
- 87°C/3mmHg(lit.)
- Density
- 1.331±0.06 g/cm3(Predicted)
- refractive index
- 1.5550 to 1.5590
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Almost colorless
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B5232
- Product name
- 1-(4-Bromophenyl)-2-methyl-1-propanone
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $136
- Updated
- 2025/07/31
- Product number
- B5232
- Product name
- 1-(4-Bromophenyl)-2-methyl-1-propanone
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $468
- Updated
- 2021/12/16
- Product number
- B698400
- Product name
- 1-(4-Bromophenyl)-2-methylpropan-1-one
- Packaging
- 250mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- V6185
- Product name
- 1-(4-Bromophenyl)-2-methylpropan-1-one
- Packaging
- 1g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- K0521202
- Product name
- 1-(4-Bromo-phenyl)-2-methyl-propan-1-one
- Packaging
- 1g
- Price
- $260
- Updated
- 2021/12/16
1-(4-Bromophenyl)-2-methylpropan-1-one Chemical Properties,Usage,Production
Synthesis
56985-67-2
49660-93-7
General procedure for the synthesis of 1-(4-bromophenyl)-2-methylpropan-1-one from 1-(4-bromophenyl)-2-methylpropan-1-ol: To a dichloromethane ( at 0 °C) containing 1-(4-bromophenyl)-2-methylpropan-1-ol (13.6 g, 60 mmol), ammonium acetate (13.8 g, 178 mmol) and 4?molecular sieves (30 g) ( 500 mL) suspension was added pyridinium chlorochromate (PCC, 19.2 g, 89 mmol) in batches. The reaction mixture was gradually warmed to room temperature and stirred continuously for 14 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with dichloromethane. The volatiles in the filtrate were removed under reduced pressure, and the resulting crude product was purified by silica gel column chromatography to afford 1-(4-bromophenyl)-2-methylpropan-1-one (12.7 g, 94% yield) as a light yellow oil, using dichloromethane as eluent. The product characterization data were as follows: mass spectra (GC-MS) m/z = 226 (100%, [M]+, C10H11BrO), 228 (100%, [M+2]+, C10H11BrO). 1H NMR (400 MHz, CDCl3) δ 7.81 (2H, d, J = 8.6Hz), 7.59 (2H, d, J = 8.6Hz ), 3.49 (1H, sept, J = 6.8Hz), 1.20 (6H, d, J = 6.8Hz).13C NMR (100MHz, CDCl3) δ 203.3, 135.0, 142.7, 132.0, 129.9, 127.9, 35.5, 19.1.
References
[1] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 972 - 979
[2] Organic Letters, 2018, vol. 20, # 10, p. 2906 - 2910
1-(4-Bromophenyl)-2-methylpropan-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
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