7-Bromo-3,4-dihydro-1H-quinolin-2-one
- Product Name
- 7-Bromo-3,4-dihydro-1H-quinolin-2-one
- CAS No.
- 14548-51-7
- Chemical Name
- 7-Bromo-3,4-dihydro-1H-quinolin-2-one
- Synonyms
- 7-broMo-3,4-dihydroquinolin-2(1H)-one;7-Bromo-3,4-dihydro-1H-quinolin-2-one;7-Bromo-3,4-dihydro-1H-quinoline-2-one;2(1H)-Quinolinone, 7-bromo-3,4-dihydro-;7-BROMO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 1G;7-BROMO-1,2,3,4-TETRAHYDRO-2-QUINOLINONE
- CBNumber
- CB02565129
- Molecular Formula
- C9H8BrNO
- Formula Weight
- 226.07
- MOL File
- 14548-51-7.mol
7-Bromo-3,4-dihydro-1H-quinolin-2-one Property
- Boiling point:
- 359.1±42.0 °C(Predicted)
- Density
- 1.559±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.08±0.20(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B691418
- Product name
- 7-Bromo-3,4-dihydro-1H-quinolin-2-one
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- P000503843
- Product name
- 7-Bromo-3,4-dihydroquinolin-2(1H)-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $42
- Updated
- 2021/12/16
- Product number
- V3363
- Product name
- 7-Bromo-3,4-dihydro-1H-quinolin-2-one
- Packaging
- 250mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- V3363
- Product name
- 7-Bromo-3,4-dihydro-1H-quinolin-2-one
- Packaging
- 1g
- Price
- $171
- Updated
- 2021/12/16
- Product number
- P000503843
- Product name
- 7-Bromo-3,4-dihydroquinolin-2(1H)-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
7-Bromo-3,4-dihydro-1H-quinolin-2-one Chemical Properties,Usage,Production
Synthesis
14548-39-1
14548-51-7
6-Bromo-2,3-dihydro-1H-inden-1-one (2.0 g, 9.5 mmol) was used as starting material and dissolved in chloroform (30 mL). Under stirring, methanesulfonic acid (6 mL) was slowly added dropwise to the reaction system. Subsequently, sodium azide (1.90 g, 9.5 mmol) was added in batches, and after addition, the reaction mixture was heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water. The aqueous phase was extracted with dichloromethane, the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate=2/1) to afford the target compound 7-bromo-3,4-dihydroquinolin-2(1H)-one (0.90 g) in 42% yield.
References
[1] Patent: CN106349241, 2017, A. Location in patent: Paragraph 0538; 0539; 0540; 0541; 0542
[2] Patent: WO2010/38901, 2010, A1. Location in patent: Page/Page column 44
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 6, p. 662 - 667
7-Bromo-3,4-dihydro-1H-quinolin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Bromo-3,4-dihydro-1H-quinolin-2-one manufacturers
- Product
- 7-Bromo-3,4-dihydro-1H-quinolin-2-one 14548-51-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.7%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26