AvibactaM

Product Name: AvibactaM
CAS No.: 1192500-31-4
Chemical Name: AvibactaM
Synonyms: EOS-60408;AvibactaM;Avibactam acid;NXL-104 free acid;Avibactam free acid;Avibactam Impurity 37;(E)-7-fluoro-3-methylhept-4-en-2-one;AVIBACTAM FREE ACID (NXL-104 FREE ACID);(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-c...;(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbox amide
CBNumber: CB02582836
Molecular Formula: C7H11N3O6S
Formula Weight: 265.24
MOL File: 1192500-31-4.mol

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AvibactaM Property

Density: 1.85
storage temp.: Store at -20°C
solubility: DMSO
form: Powder
pka: -4.59±0.18(Predicted)
color: White to off-white
InChI: InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1
InChIKey: NDCUAPJVLWFHHB-UHNVWZDZSA-N
SMILES: S(O)(ON1C(=O)[N@@]2C[C@@]1([H])CC[C@H]2C(N)=O)(=O)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0013803
Product name: AVIBACTAM
Purity: 95.00%
Packaging: 5MG
Price: $499.8
Updated: 2021/12/16

ApexBio Technology

Product number: A3205
Product name: Avibactam
Packaging: 5mg
Price: $537
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013803
Product name: AVIBACTAM
Purity: 95.00%
Packaging: 100MG
Price: $995
Updated: 2021/12/16

Crysdot

Product number: CD31004353
Product name: Avibactamfreeacid
Purity: 98+%
Packaging: 50mg
Price: $1050
Updated: 2021/12/16

Chemenu

Product number: CM202052
Product name: (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-ylhydrogensulfate
Purity: 98%
Packaging: 50mg
Price: $982
Updated: 2021/12/16

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AvibactaM Chemical Properties,Usage,Production

Uses

Avibactam Butylammonium Salt is a novel β-lactamase inhibitor with a non-lactam structural scaffold. Avibactam irreversibly inhibits lactamase from Mycobacterium tuberculosis.

Definition

ChEBI: A member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) n combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis.

Enzyme inhibitor

This non-β-lactam inhibitor of β-lactamase (FW = 261.27 g/mol; CAS 1192500-31-4), also known as NLX104 and AVE1330A, shows a spectrum of action against Classes A and C β-lactamase as well as selected Class D β-lactamase, enzymes that often confer resistance to β-lactam antibiotics. By forming a high-affinity complex with its target enzymes, avibactam enhances the antibacterial activity of certain β-lactam drugs, such as ceftaroline. With over 1000 known β-lactamase, the action of avibactam is apt to depend on the invidual active-site interactions. Mode of Action: Acylation and deacylation rates have been measured for the clinically important enzymes CTX-M-15, KPC-2, E. cloacae AmpC, P. aeruginosa AmpC, OXA-10, and OXA-48. The efficiency of acylation (kon/Ki) varies across the enzyme spectrum, from 1.1 x 101 M–1 s –1 for OXA-10 to 1.0 x 105 M–1 s –1 for CTX-M-15. Inhibition of OXA-10 was shown to follow a reversible covalent mechanism (see below), and the acylated OXA-10 displayed the longest residence time for deacylation, with a half-life of greater than 5 days. The inhibited enzyme forms are stable to hydrolysis for all enzymes with the exception of KPC-2, which displays slow hydrolytic route that involved fragmentation of the acyl-avibactam complex. In the case of TEM-1 lactamase, avibactam slowly covalently acylates its target, and the acylated enzyme subsequently undergoes slow deacylation (koff = 0.045 min?1 ) regenerating avibactam intact. Use as a Combined Drug: Combination of avibactim with extended-spectrum cephalosporins or aztreonam shows promise in inhibiting Klebsiella pneumoniae (KP) isolates harboring carbapenemases, or KPCs. Given abundant experience with ceftazidime and the significant improvement avibactam provides against contemporary β-lactamase-producing Gram-negative pathogens, this combination will likely play a role in the treatment of complicated urinary tract infections (as monotherapy) and complicated intra-abdominal infections (in combination with metronidazole) caused (or suspected to be caused) by otherwise resistant pathogens, such as extended spectrum β-lactamase-, AmpC-, or Klebsiella pneumoniae carbapenemase producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.

in vivo

Ceftazidime-Avibactam (0.375?mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model^[3].
Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection^[3].

Animal Model:	Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model^[4]
Dosage:	0.375?mg/g in combination with Ceftazidime
Administration:	Subcutaneous injection, 4?h post infection and given every 8?h for 10?days
Result:	70% of infection group mice died within 4?days, and all mice in the PBS group died within 13?days. All treatment group mice survived at 10 days post infection with the antibiotic applied every 8?h, whereas 100% of mice in this group died within 4?days after the antibiotic treatment stopped. The spleen and liver of treatment group mice showed lower CFU counts, as compare with that of infected group.

AvibactaM Preparation Products And Raw materials

Raw materials

Preparation Products

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AvibactaM Suppliers

China 111 France 1 India 1 United States 8 Global 121

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Nanjing hongshenghuo Biotechnology Co., Ltd

Tel: 025-58311670 18020159086
Email: 54604129@qq.com
Country: China
ProdList: 185
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

Chemvon Biotechnology Co., Ltd

Tel: 021-50790412
Fax: +86-21-50790419
Email: info@chemvon.com
Country: China
ProdList: 371
Advantage: 57

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

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View Lastest Price from AvibactaM manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: AvibactaM 1192500-31-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Avibactam 1192500-31-4
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2025-03-19

shandong perfect biotechnology co.ltd

Product: Avibactam 1192500-31-4
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 1kg
Release date: 2023-08-02

1192500-31-4, AvibactaMRelated Search:

Sodium bisulfate monohydrate Avibactam sodium Avibactam (sodium hydrate)

AvibactaM

Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester

(E)-7-fluoro-3-methylhept-4-en-2-one

Avibactam free acid

AVIBACTAM FREE ACID (NXL-104 FREE ACID)

Avibactam Impurity 37

Avibactam,(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbox amide

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-ylhydrogensulfate

(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbox amide

EOS-60408

Avibactam acid

NXL-104 free acid

(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-c...

(1R,2S,5R)-2-Carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate

(2r,5s)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate

1192500-31-4

C7H11N3O6S