AvibactaM
- Product Name
- AvibactaM
- CAS No.
- 1192500-31-4
- Chemical Name
- AvibactaM
- Synonyms
- EOS-60408;AvibactaM;Avibactam acid;NXL-104 free acid;Avibactam free acid;Avibactam Impurity 37;(E)-7-fluoro-3-methylhept-4-en-2-one;AVIBACTAM FREE ACID (NXL-104 FREE ACID);(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-c...;(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbox amide
- CBNumber
- CB02582836
- Molecular Formula
- C7H11N3O6S
- Formula Weight
- 265.24
- MOL File
- 1192500-31-4.mol
AvibactaM Property
- Density
- 1.85
- storage temp.
- Store at -20°C
- solubility
- DMSO
- form
- Powder
- pka
- -4.59±0.18(Predicted)
N-Bromosuccinimide Price
- Product number
- API0013803
- Product name
- AVIBACTAM
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- A3205
- Product name
- Avibactam
- Packaging
- 5mg
- Price
- $537
- Updated
- 2021/12/16
- Product number
- API0013803
- Product name
- AVIBACTAM
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $995
- Updated
- 2021/12/16
- Product number
- CD31004353
- Product name
- Avibactamfreeacid
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- CM202052
- Product name
- (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-ylhydrogensulfate
- Purity
- 98%
- Packaging
- 50mg
- Price
- $982
- Updated
- 2021/12/16
AvibactaM Chemical Properties,Usage,Production
Uses
Avibactam Butylammonium Salt is a novel β-lactamase inhibitor with a non-lactam structural scaffold. Avibactam irreversibly inhibits lactamase from Mycobacterium tuberculosis.
Definition
ChEBI: A member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) n combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis.
Enzyme inhibitor
This non-β-lactam inhibitor of β-lactamase (FW = 261.27 g/mol; CAS 1192500-31-4), also known as NLX104 and AVE1330A, shows a spectrum of action against Classes A and C β-lactamase as well as selected Class D β-lactamase, enzymes that often confer resistance to β-lactam antibiotics. By forming a high-affinity complex with its target enzymes, avibactam enhances the antibacterial activity of certain β-lactam drugs, such as ceftaroline. With over 1000 known β-lactamase, the action of avibactam is apt to depend on the invidual active-site interactions. Mode of Action: Acylation and deacylation rates have been measured for the clinically important enzymes CTX-M-15, KPC-2, E. cloacae AmpC, P. aeruginosa AmpC, OXA-10, and OXA-48. The efficiency of acylation (kon/Ki) varies across the enzyme spectrum, from 1.1 x 101 M–1 s –1 for OXA-10 to 1.0 x 105 M–1 s –1 for CTX-M-15. Inhibition of OXA-10 was shown to follow a reversible covalent mechanism (see below), and the acylated OXA-10 displayed the longest residence time for deacylation, with a half-life of greater than 5 days. The inhibited enzyme forms are stable to hydrolysis for all enzymes with the exception of KPC-2, which displays slow hydrolytic route that involved fragmentation of the acyl-avibactam complex. In the case of TEM-1 lactamase, avibactam slowly covalently acylates its target, and the acylated enzyme subsequently undergoes slow deacylation (koff = 0.045 min?1 ) regenerating avibactam intact. Use as a Combined Drug: Combination of avibactim with extended-spectrum cephalosporins or aztreonam shows promise in inhibiting Klebsiella pneumoniae (KP) isolates harboring carbapenemases, or KPCs. Given abundant experience with ceftazidime and the significant improvement avibactam provides against contemporary β-lactamase-producing Gram-negative pathogens, this combination will likely play a role in the treatment of complicated urinary tract infections (as monotherapy) and complicated intra-abdominal infections (in combination with metronidazole) caused (or suspected to be caused) by otherwise resistant pathogens, such as extended spectrum β-lactamase-, AmpC-, or Klebsiella pneumoniae carbapenemase producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.
AvibactaM Preparation Products And Raw materials
Raw materials
Preparation Products
AvibactaM Suppliers
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
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- China
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- 7998
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- 021-67187366 19901745723
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- China
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- 025-58311670 18020159086
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- China
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- 021-50182298 021-50180596
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- +86-21-57758967
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- China
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- 2210
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- 021-50790412
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- +86-21-50790419
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- China
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- 021-20908456
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- 021-58180499
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- China
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- 1-631-485-4226; 16314854226
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- United States
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- 021-58955995
- Fax
- 609-228-5909
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- United States
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- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
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- United States
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- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
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View Lastest Price from AvibactaM manufacturers
- Product
- Avibactam 1192500-31-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98% HPLC
- Supply Ability
- 1kg
- Release date
- 2023-08-02
- Product
- Avibactam 1192500-31-4
- Price
- US $200.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 1000t/month
- Release date
- 2022-11-22
- Product
- Avibactam 1192500-31-4
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Months
- Release date
- 2022-11-20