ChemicalBook > CAS DataBase List > ATN-161

ATN-161

Product Name: ATN-161
CAS No.: 262438-43-7
Chemical Name: ATN-161
Synonyms: ATN-161;AC-PHSCN-NH2;ATN161; ATN 161;ATN-161(free base);ATN-161 >=98% (HPLC);ATN-161 (Ac-PHSCN-NH2);ATN-161/262438-43-7/98%;L-Aspartamide, 1-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-;(S)-2-((R)-2-((S)-2-((S)-2-((S)-1-Acetylpyrrolidine-2-carboxamido)-3-(1H-imidazol-4-yl)propanamido)-3-hydroxypropanamido)-3-mercaptopropanamido)succinamide;(S)-2-((R)-2-((S)-2-((S)-2-((S)-1-Acetylpyrrolidine-2-carboxamido)-3-(1H-imidazol-5-yl)propanamido)-3-hydroxypropanamido)-3-mercaptopropanamido)succinamide
CBNumber: CB02582856
Molecular Formula: C23H35N9O8S
Formula Weight: 597.64
MOL File: 262438-43-7.mol

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ATN-161 Property

Boiling point:: 1297.2±65.0 °C(Predicted)
Density: 1.443±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Water:7.5(Max Conc. mg/mL);12.56(Max Conc. mM)
pka: 9.14±0.10(Predicted)
form: Solid
color: White to Off-White
Water Solubility: Soluble to 2 mg/ml in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2079
Product name: ATN-161
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $135
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML4164
Product name: ATN-161 trifluoroacetate salt
Purity: ≥95% (HPLC)
Packaging: 1 unit
Price: $545
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2079
Product name: ATN-161
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $545
Updated: 2025/07/31

Tocris

Product number: 6058
Product name: ATN161
Packaging: 10
Price: $238
Updated: 2021/12/16

TRC

Product number: A790550
Product name: ATN161
Packaging: 5mg
Price: $165
Updated: 2021/12/16

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ATN-161 Chemical Properties,Usage,Production

Uses

ATN 161 is an α5β1 integrin inhibitor that has advanced to phase II clinical trials to treat solid tumors.

Biological Activity

ATN-161 is a non-RGD based integrin binding peptide derived from the synergy region of fibronectin th at inhibits the receptors for integrins alpha-v beta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 was shown to have antiangigenic and antitumor activity.

in vivo

The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density^[1]. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564^[2].

storage

Store at -20°C

ATN-161 Preparation Products And Raw materials

Raw materials

Preparation Products

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ATN-161 Suppliers

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262438-43-7, ATN-161Related Search:

ATN161; ATN 161

(S)-2-((R)-2-((S)-2-((S)-2-((S)-1-Acetylpyrrolidine-2-carboxamido)-3-(1H-imidazol-5-yl)propanamido)-3-hydroxypropanamido)-3-mercaptopropanamido)succinamide

ATN-161

ATN-161(free base)

ATN-161 (Ac-PHSCN-NH2)

L-Aspartamide, 1-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-

ATN-161 >=98% (HPLC)

AC-PHSCN-NH2

(S)-2-((R)-2-((S)-2-((S)-2-((S)-1-Acetylpyrrolidine-2-carboxamido)-3-(1H-imidazol-4-yl)propanamido)-3-hydroxypropanamido)-3-mercaptopropanamido)succinamide

ATN-161/262438-43-7/98%

262438-43-7