ATN-161
- Product Name
- ATN-161
- CAS No.
- 262438-43-7
- Chemical Name
- ATN-161
- Synonyms
- ATN-161;AC-PHSCN-NH2;ATN161; ATN 161;ATN-161(free base);ATN-161 >=98% (HPLC);ATN-161 (Ac-PHSCN-NH2);ATN-161/262438-43-7/98%;L-Aspartamide, 1-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-;(S)-2-((R)-2-((S)-2-((S)-2-((S)-1-Acetylpyrrolidine-2-carboxamido)-3-(1H-imidazol-4-yl)propanamido)-3-hydroxypropanamido)-3-mercaptopropanamido)succinamide;(S)-2-((R)-2-((S)-2-((S)-2-((S)-1-Acetylpyrrolidine-2-carboxamido)-3-(1H-imidazol-5-yl)propanamido)-3-hydroxypropanamido)-3-mercaptopropanamido)succinamide
- CBNumber
- CB02582856
- Molecular Formula
- C23H35N9O8S
- Formula Weight
- 597.64
- MOL File
- 262438-43-7.mol
ATN-161 Property
- Boiling point:
- 1297.2±65.0 °C(Predicted)
- Density
- 1.443±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Water:7.5(Max Conc. mg/mL);12.56(Max Conc. mM)
- pka
- 9.14±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Soluble to 2 mg/ml in water
N-Bromosuccinimide Price
- Product number
- SML2079
- Product name
- ATN-161
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $135
- Updated
- 2025/07/31
- Product number
- SML4164
- Product name
- ATN-161 trifluoroacetate salt
- Purity
- ≥95% (HPLC)
- Packaging
- 1 unit
- Price
- $545
- Updated
- 2025/07/31
- Product number
- SML2079
- Product name
- ATN-161
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $545
- Updated
- 2025/07/31
- Product number
- 6058
- Product name
- ATN161
- Packaging
- 10
- Price
- $238
- Updated
- 2021/12/16
- Product number
- A790550
- Product name
- ATN161
- Packaging
- 5mg
- Price
- $165
- Updated
- 2021/12/16
ATN-161 Chemical Properties,Usage,Production
Uses
ATN 161 is an α5β1 integrin inhibitor that has advanced to phase II clinical trials to treat solid tumors.
Biological Activity
ATN-161 is a non-RGD based integrin binding peptide derived from the synergy region of fibronectin th at inhibits the receptors for integrins alpha-v beta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 was shown to have antiangigenic and antitumor activity.
in vivo
The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density[1]. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564[2].
storage
Store at -20°C
ATN-161 Preparation Products And Raw materials
Raw materials
Preparation Products
ATN-161 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58