ChemicalBook > CAS DataBase List > N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE

N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE

Product Name
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
CAS No.
127917-66-2
Chemical Name
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
Synonyms
RO 41-1049 HYDROCHLORIDE;Ro 411049 hydrochloride,Ro 41 1049 hydrochloride;N-(2-Aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide hydrochloride;N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
CBNumber
CB0258423
Molecular Formula
C12H13ClFN3OS
Formula Weight
301.76
MOL File
Mol file
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N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Property

storage temp. 
Store at -20°C
solubility 
H2O: soluble
form 
solid
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5591
Product name
Ro41-1049(hydrochloride)
Purity
99.96%
Packaging
5mg
Price
$72
Updated
2021/12/16
ChemScene
Product number
CS-5591
Product name
Ro41-1049(hydrochloride)
Purity
99.96%
Packaging
10mg
Price
$108
Updated
2021/12/16
ChemScene
Product number
CS-5591
Product name
Ro41-1049(hydrochloride)
Purity
99.96%
Packaging
50mg
Price
$288
Updated
2021/12/16
ChemScene
Product number
CS-5591
Product name
Ro41-1049(hydrochloride)
Purity
99.96%
Packaging
100mg
Price
$480
Updated
2021/12/16
Crysdot
Product number
CD31004006
Product name
Ro41-1049hydrochloride
Purity
98+%
Packaging
5mg
Price
$46
Updated
2021/12/16
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N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (MAO-A). An homogeneous population of high affinity binding sites for [3H]Ro 41-1049 is found in membrane preparations from human frontal cortex and placenta (Kd values of 16.5 and 64.4 nM, respectively)[1].

in vivo

Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion. Pretreatment with Ro 41-1049 (20 mg/kg) significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing formation of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[2].

Animal Model:Sprague-Dawley rats (200-240 g)[2]
Dosage:1 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, or 50 mg/kg
Administration: Intraperitoneal injection; for 3 hours
Result:Inhibited dopamine metabolite formation and increased dopamine levels in a dose-dependent fashion. Pretreatment with the concentration of 20 mg/kg significantly increased dopamine formation following L-dopa administration while decreasing formation of DOPAC and HVA.

References

[1] Cesura AM, et al. Characterization of the binding of [3H]Ro 41-1049 to the active site of human monoamine oxidase-A. Mol Pharmacol. 1990 Mar;37(3):358-66. PMID:2314388
[2] Brannan T, et al. Effect of a selective MAO-A inhibitor (Ro 41-1049) on striatal L-dopa and dopamine metabolism: an in vivo study. J Neural Transm Park Dis Dement Sect. 1994;8(1-2):99-105. DOI:10.1007/BF02250920

N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Suppliers

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127917-66-2, N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDERelated Search:


  • RO 41-1049 HYDROCHLORIDE
  • N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
  • Ro 411049 hydrochloride,Ro 41 1049 hydrochloride
  • N-(2-Aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide hydrochloride
  • 127917-66-2
  • C12H12FN3OSHCl