4-broMo-2-phenylthiazole
- Product Name
- 4-broMo-2-phenylthiazole
- CAS No.
- 141305-40-0
- Chemical Name
- 4-broMo-2-phenylthiazole
- Synonyms
- 4-broMo-2-phenylthiazole;Thiazole,4-bromo-2-phenyl-;4-bromo-2-phenyl-1,3-thiazole
- CBNumber
- CB02598497
- Molecular Formula
- C9H6BrNS
- Formula Weight
- 240.12
- MOL File
- 141305-40-0.mol
4-broMo-2-phenylthiazole Property
- Melting point:
- 65-67 °C
- Boiling point:
- 335.6±34.0 °C(Predicted)
- Density
- 1.563±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- pka
- -0.34±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- Y7505
- Product name
- 4-Bromo-2-phenylthiazole
- Packaging
- 250mg
- Price
- $271
- Updated
- 2021/12/16
- Product number
- FB75289
- Product name
- 4-Bromo-2-phenylthiazole
- Packaging
- 250mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- Y7505
- Product name
- 4-Bromo-2-phenylthiazole
- Packaging
- 1g
- Price
- $597
- Updated
- 2021/12/16
- Product number
- FB75289
- Product name
- 4-Bromo-2-phenylthiazole
- Packaging
- 500mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- FB75289
- Product name
- 4-Bromo-2-phenylthiazole
- Packaging
- 1g
- Price
- $1000
- Updated
- 2021/12/16
4-broMo-2-phenylthiazole Chemical Properties,Usage,Production
Synthesis
4175-77-3
98-80-6
141305-40-0
Palladium(II) acetate (0.084 g, 0.38 mmol) was mixed with xantphos (0.220 g, 0.38 mmol) in 25 mL of tetrahydrofuran under nitrogen atmosphere. After stirring for 5 min, the resulting solution was transferred to a round-bottomed flask containing 2,4-dibromothiazole (3.64 g, 15 mmol), phenylboronic acid (1.96 g, 16 mmol) and potassium phosphate (9.55 g, 45 mmol). The reaction mixture was heated at 60 °C for 18 h, subsequently cooled to room temperature, filtered and washed with dichloromethane. The solvent was removed under reduced pressure to afford the crude product, which was purified by silica gel column chromatography using hexane:ethyl acetate as eluent to afford 4-bromo-2-phenylthiazole as a white solid (3 g, 84% yield).1H NMR (400 MHz, CDCl3) δ: 7.95 (dd, J = 3.4 Hz, 8.2 Hz, 2H), 7.47-7.46 (m 3H), 7.23 (s, 1H).LRMS (ESI) calculated value C9H6BrNS [M + H]+: 241.12, measured value: 241.00.
References
[1] Patent: WO2015/191630, 2015, A1. Location in patent: Paragraph 00287
[2] Journal of Organic Chemistry, 2010, vol. 75, # 5, p. 1733 - 1739
[3] Patent: JP2018/140974, 2018, A. Location in patent: Paragraph 0067; 0068
[4] Patent: EP2455371, 2012, A1. Location in patent: Page/Page column 22
[5] Patent: US2013/296271, 2013, A1. Location in patent: Paragraph 0175
4-broMo-2-phenylthiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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