(Difluoromethyl)trimethylsilane

Product Name: (Difluoromethyl)trimethylsilane
CAS No.: 65864-64-4
Chemical Name: (Difluoromethyl)trimethylsilane
Synonyms: Difluormethyltrimethylsilan;(DifluoroMethyl)triMethylsilane;TriMethyl(difluoroMethyl)silane;Silane, (difluoroMethyl)triMethyl-;(Difluoromethyl)trimethylsilane>(Difluoromethyl)trimethylsilane,97%;(Difluoromethyl)trimethylsilane >=98.0% (GC)
CBNumber: CB02610597
Molecular Formula: C4H10F2Si
Formula Weight: 124.2
MOL File: 65864-64-4.mol

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(Difluoromethyl)trimethylsilane Property

Boiling point:: 52°C(lit.)
Density: 0.877±0.06 g/cm3(Predicted)
refractive index: 1.3560-1.3600
Flash point:: -17℃
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
form: clear liquid
color: Colorless to Almost colorless
Specific Gravity: 0.91
Hydrolytic Sensitivity: 4: no reaction with water under neutral conditions
BRN: 2423974
InChIKey: OOKFLLNDYNWCHK-UHFFFAOYSA-N
CAS DataBase Reference: 65864-64-4

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Safety

Hazard Codes: F
Risk Statements: 11
Safety Statements: 15-7-35
RIDADR: UN 1993BF 3 / PGII
WGK Germany: 3
HazardClass: 3
PackingGroup: II
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H225Highly Flammable liquid and vapour
Precautionary statements: P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 744050
Product name: (Difluoromethyl)trimethylsilane
Purity: ≥98.0% (GC)
Packaging: 1ml
Price: $264
Updated: 2024/03/01

Sigma-Aldrich

Product number: 744050
Product name: (Difluoromethyl)trimethylsilane
Purity: ≥98.0% (GC)
Packaging: 5ml
Price: $756
Updated: 2024/03/01

TCI Chemical

Product number: D4364
Product name: (Difluoromethyl)trimethylsilane
Purity: >97.0%(GC)
Packaging: 1mL
Price: $54
Updated: 2024/03/01

TCI Chemical

Product number: D4364
Product name: (Difluoromethyl)trimethylsilane
Purity: >97.0%(GC)
Packaging: 5mL
Price: $176
Updated: 2024/03/01

TCI Chemical

Product number: D4364
Product name: (Difluoromethyl)trimethylsilane
Purity: >97.0%(GC)
Packaging: 25mL
Price: $503
Updated: 2023/01/07

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(Difluoromethyl)trimethylsilane Chemical Properties,Usage,Production

Description

A direct nucleophilic difluoromethylation reagent. The nucleophilic activation of the silicon center with Lewis base initiators allows transfer of the difluoromethyl moiety to electrophiles such as aldehydes, ketones, and aldimines. The copper-mediated difluoromethylation of halides using TMSCF2H tolerates amine, ether, amide, ester, aromatic bromide, and protected alcohol functionalities in aryl iodides and occurs in high yield and stereoselectivity with vinyl iodides.

Uses

(Difluoromethyl)trimethylsilane, can be used for difluoromethylation of carbonyl compounds. Difluromethylated compounds are very useful in materials science and medicinal and agricultural chemistry.

Reactions

(1) Direct bromination to prepare TMSCF2Br.

(2) Difluoromethylation of aldehydes and ketones.

(3) Difluoromethylation of aldimines.

(4) Difluoromethylation of aryl and vinyl iodides.

References

[1] MIKHAIL D. KOSOBOKOV. Difluoro(trimethylsilyl)acetonitrile: Synthesis and Fluoroalkylation Reactions[J]. The Journal of Organic Chemistry, 2012, 77 13: 5850-5855. DOI:10.1021/jo301094b.
[2] YANCHUAN ZHAO. Efficient and Direct Nucleophilic Difluoromethylation of Carbonyl Compounds and Imines with Me3SiCF2H at Ambient or Low Temperature[J]. Organic Letters, 2011, 13 19: 5342-5345. DOI:10.1021/ol202208b.
[3] PATRICK S. FIER  John F H. Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides[J]. Journal of the American Chemical Society, 2012, 134 12: 5524-5527. DOI:10.1021/ja301013h.

(Difluoromethyl)trimethylsilane Preparation Products And Raw materials

Raw materials

Preparation Products

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(Difluoromethyl)trimethylsilane Suppliers

Americas 1 China 121 Europe 1 India 2 Japan 1 Russia 1 Switzerland 1 United Kingdom 2 United States 10 Global 140

Alfa Chemistry

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View Lastest Price from (Difluoromethyl)trimethylsilane manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: (Difluoromethyl)trimethylsilane 65864-64-4
Price: US $0.10/kg
Min. Order: 0.004999999888241291kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-15

Henan Aochuang Chemical Co.,Ltd.

Product: (Difluoromethyl)trimethylsilane 65864-64-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: (Difluoromethyl)trimethylsilane 65864-64-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

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65864-64-4

C4H10F2Si