acetyl Methanesulfonate
- Product Name
- acetyl Methanesulfonate
- CAS No.
- 5539-53-7
- Chemical Name
- acetyl Methanesulfonate
- Synonyms
- NSC 158252;Busulfan Impurity 6;Busulfan Impurity 10;Methanesulfonyl acetate;acetyl Methanesulfonate;Acetic acid, anhydride with methanesulfonic acid
- CBNumber
- CB02610946
- Molecular Formula
- C3H6O4S
- Formula Weight
- 138.14
- MOL File
- 5539-53-7.mol
acetyl Methanesulfonate Property
- Boiling point:
- 56 °C(Press: 0.01 Torr)
- Density
- 1.346±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- Chloroform (Sparingly)
- form
- Oil
- color
- Yellow
- Stability:
- Extremely Moisture Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A173895
- Product name
- AcetylMethanesulfonate
- Packaging
- 10g
- Price
- $755
- Updated
- 2021/12/16
acetyl Methanesulfonate Chemical Properties,Usage,Production
Uses
Acetyl Methanesulfonate, is an impurity of Busulfan (B689900), an alkylating agent with antileukemic activity. Antineoplastic. It is a reagent for ether cleavage, for the cleavage of activated cyclopropanes as partial structures of cyclopropyl ketones, and for acetylation of aromatic rings.
Preparation
Preparative Methods: Acetyl Methanesulfonate can be prepared on a large scale (1 mol) from Acetyl Chloride and Methanesulfonic Acid by heating at reflux followed by fractional distillation (85% yield).
storage
Handling, Storage, and Precautions: slightly hygroscopic. However, no particular precautions are required upon exposure to air for a short period of time. acetyl Methanesulfonate is stable if stored at 4 °C for several months. Use in a fume hood.
Purification Methods
The main impurity is methanesulfonic acid. Reflux it with redistilled acetyl chloride for 6-10hours, i.e. until no further HCl is absorbed in a trap, and exclude moisture. Distil off excess of AcCl and carefully distil it below 0.001mm with the bath temperature below 120o to give the anhydride as a pale yellow oil which solidifies below 0o. Below ~130o it gives the disulfonic anhydride, and above ~130o polymers are formed, and it is used for cleaving ethers [Preparation, IR, NMR: Karger & Mazur J Org Chem 36 528, 532 1971]. [Beilstein 2 H 166, 2 III 349.]
acetyl Methanesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
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