BUSULFAN-D8
- Product Name
- BUSULFAN-D8
- CAS No.
- 116653-28-2
- Chemical Name
- BUSULFAN-D8
- Synonyms
- GT-41-d8;Myleran-d;CB-2041-d8;Myleran-d8;Misulban-d8;Busulfex-d8;Busulfan-d8;Busulphan-d8;Bai Xiao'an D8;Busulfan-D8(tetramethylene)
- CBNumber
- CB6177667
- Molecular Formula
- C6H6D8O6S2
- Formula Weight
- 254.35
- MOL File
- 116653-28-2.mol
BUSULFAN-D8 Property
- Melting point:
- 112-1140C
- storage temp.
- -20°C Freezer
- solubility
- DMF: 16.7 mg/ml,DMSO: 16.7 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- form
- A crystalline solid
- color
- White to off-white
- CAS Number Unlabeled
- 55-98-1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H350May cause cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P320Specific treatment is urgent (see … on this label).
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23096
- Product name
- Busulfan-d8
- Purity
- ≥99% deuterated forms (d1-d8)
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 23096
- Product name
- Busulfan-d8
- Purity
- ≥99% deuterated forms (d1-d8)
- Packaging
- 5mg
- Price
- $284
- Updated
- 2024/03/01
- Product number
- B8996-01
- Product name
- Busulfan-d8
- Packaging
- 2.5mg
- Price
- $355
- Updated
- 2021/12/16
- Product number
- B689902
- Product name
- Busulfan-d8
- Packaging
- 25mg
- Price
- $1355
- Updated
- 2021/12/16
- Product number
- 5504DF
- Product name
- Busulfan-d8
- Packaging
- 1mg
- Price
- $166
- Updated
- 2021/12/16
BUSULFAN-D8 Chemical Properties,Usage,Production
Description
Busulfan-d8 is intended for use as an internal standard for the quantification of busulfan by GC- or LC-MS. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent. It forms both intra- and interstrand crosslinks on DNA. In mammals, busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.
Chemical Properties
White Solid
Uses
Alkylating agent with antileukemic activity. Antineoplastic
References
[1] APPELBAUM F. Is there a best transplant conditioning regimen for acute myeloid leukemia?[J]. Leukemia, 2000, 14 3: 497-501. DOI: 10.1038/sj.leu.2401601
[2] TAKUYA IWAMOTO. DNA intrastrand cross-link at the 5′-GA-3′ sequence formed by busulfan and its role in the cytotoxic effect[J]. Cancer Science, 2005, 95 5: 454-458. DOI: 10.1111/j.1349-7006.2004.tb03231.x
[3] M PONTI. DNA interstrand crosslinking and sequence selectivity of dimethanesulphonates[J]. British Journal of Cancer, 1991, 63 5: 743-747. DOI: 10.1038/bjc.1991.166
[4] E. COPELAN H D. Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiation.[J]. Blood, 1992, 24 1: 1648-1658. DOI: 10.1182/blood.v80.7.1648.1648
BUSULFAN-D8 Preparation Products And Raw materials
Raw materials
Preparation Products
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