TriMethyl(broModifluoroMethyl)silane
- Product Name
- TriMethyl(broModifluoroMethyl)silane
- CAS No.
- 115262-01-6
- Chemical Name
- TriMethyl(broModifluoroMethyl)silane
- Synonyms
- (BroModifluoroMethyl)triMethylsilane;(Bromodifluoromethyl);Difluorobromomethylsilane;TriMethyl(broModifluoroMethyl)silane;Bromodifluoro(trimethylsilyl)methane;Silane, (bromodifluoromethyl)trimethyl-;Trimethyl(bromodifluoromethyl)silane 97%;(Bromodifluoromethyl)trimethylsilane 98%;(Bromodifluoromethyl)trimethylsilane >(Bromodifluoromethyl)trimethylsilane, 98+%
- CBNumber
- CB02611493
- Molecular Formula
- C4H9BrF2Si
- Formula Weight
- 203.1
- MOL File
- 115262-01-6.mol
TriMethyl(broModifluoroMethyl)silane Property
- Boiling point:
- 108°C(lit.)
- Density
- 1.306
- refractive index
- n/D1.407
- Flash point:
- 46℃
- storage temp.
- -20°C
- form
- liquid
- color
- clear
- InChIKey
- WDZVWBWAUSUTTO-UHFFFAOYSA-N
- CAS DataBase Reference
- 115262-01-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 808601
- Product name
- (Bromodifluoromethyl)
- Purity
- 98%
- Packaging
- 1g
- Price
- $118
- Updated
- 2023/01/07
- Product number
- B4325
- Product name
- (Bromodifluoromethyl)trimethylsilane
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $93
- Updated
- 2024/03/01
- Product number
- B4325
- Product name
- (Bromodifluoromethyl)trimethylsilane
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $281
- Updated
- 2024/03/01
- Product number
- T895825
- Product name
- Trimethyl(bromodifluoromethyl)silane
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB60402
- Product name
- (Bromodifluoromethyl)trimethylsilane
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
TriMethyl(broModifluoroMethyl)silane Chemical Properties,Usage,Production
Chemical Properties
Colorless transparent liquid, initial boiling point 108℃, relative density 1.31 g/cm3.
Uses
Novel difluorocarbene source for the efficient difluoromethylenation of alkenes/alkynes and difluoromethylation of O-, S-, and N-nucleophiles.
Uses
Trimethyl(bromodifluoromethyl)silane can be used as neuroactive steroids.
Uses
As reported by Hu and co-workers, (Bromodifluoromethyl)trimethylsilane is a highly useful reagent for the formation of difluoromethene-containing 3-membered rings and can also difluoromethylate heteroatoms with the assistance of alkaline bases, most effectively KOH.
Application
- TriMethyl(broModifluoroMethyl)silane commonly can be used as a source for generating difluorocarbene, it is a general reagent with broad synthetic utility.
- Can generate difluorocarbene under neutral/acidic/basic conditions in the presence/absence of water at low/high temperatures.
- Can be used to prepare gem-difluorocyclopropan(e)nes, O-, S-, N-, and P-difluoromethylated compounds
Reactions
(1) Difluoromethylenation of TMSCN.
Ref. J. Org. Chem. 2012, 77, 5850?5855.
(2) Difluoromethylenation of benzyl and alkylzinc halides.
Ref. Org. Lett. 2013, 15, 917 – 919.
(3) Fluorination aminocarbonylation of aldehydes
Ref. Angew. Chem. Int. Ed. 2022, e202115467
General Description
(Bromodifluoromethyl)trimethylsilane (TMSCF2Br) is commonly used as a source to generate dilfluorocarbene. TMSCF3 (Ruppert–Prakash reagent) and BBr3 undergoes fast halogen–exchange reaction to form MSCF2Br.
References
[1]Angewandte Chemie International Edition.DOI :10.1002/anie.202283811
[2]The Journal of Organic Chemistry.DOI :10.1021/acs.orglett.2c02899
TriMethyl(broModifluoroMethyl)silane Preparation Products And Raw materials
Raw materials
Preparation Products
TriMethyl(broModifluoroMethyl)silane Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
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- 23653
- Advantage
- 75
View Lastest Price from TriMethyl(broModifluoroMethyl)silane manufacturers
- Product
- TriMethyl(broModifluoroMethyl)silane 115262-01-6
- Price
- US $0.10/kg
- Min. Order
- 0.004999999888241291kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-15
- Product
- TriMethyl(broModifluoroMethyl)silane 115262-01-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09
- Product
- (Bromodifluoromethyl)trimethylsilane 115262-01-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10